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Gene: RSPH9 |
Gene summary for RSPH9 |
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Gene information | Species | Human | Gene symbol | RSPH9 | Gene ID | 221421 |
Gene name | radial spoke head component 9 | |
Gene Alias | C6orf206 | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q9H1X1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221421 | RSPH9 | ATC13 | Human | Thyroid | ATC | 2.27e-33 | 7.91e-01 | 0.34 |
221421 | RSPH9 | ATC5 | Human | Thyroid | ATC | 1.15e-38 | 8.31e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RSPH9 | SNV | Missense_Mutation | c.577G>A | p.Asp193Asn | p.D193N | Q9H1X1 | protein_coding | tolerated(0.41) | probably_damaging(0.957) | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RSPH9 | SNV | Missense_Mutation | rs759307099 | c.133C>A | p.Leu45Ile | p.L45I | Q9H1X1 | protein_coding | deleterious(0.03) | possibly_damaging(0.801) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RSPH9 | SNV | Missense_Mutation | c.208N>T | p.Pro70Ser | p.P70S | Q9H1X1 | protein_coding | tolerated(0.42) | benign(0.003) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RSPH9 | SNV | Missense_Mutation | rs746345623 | c.70N>A | p.Arg24Ser | p.R24S | Q9H1X1 | protein_coding | tolerated(0.09) | possibly_damaging(0.769) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
RSPH9 | SNV | Missense_Mutation | c.130N>A | p.Val44Ile | p.V44I | Q9H1X1 | protein_coding | tolerated(0.11) | benign(0.069) | TCGA-DM-A282-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RSPH9 | SNV | Missense_Mutation | rs139002825 | c.466N>T | p.Arg156Trp | p.R156W | Q9H1X1 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RSPH9 | SNV | Missense_Mutation | novel | c.732N>T | p.Glu244Asp | p.E244D | Q9H1X1 | protein_coding | tolerated_low_confidence(0.22) | probably_damaging(0.996) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RSPH9 | SNV | Missense_Mutation | rs150021750 | c.328N>A | p.Glu110Lys | p.E110K | Q9H1X1 | protein_coding | tolerated(0.21) | possibly_damaging(0.557) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
RSPH9 | SNV | Missense_Mutation | rs759307099 | c.133C>A | p.Leu45Ile | p.L45I | Q9H1X1 | protein_coding | deleterious(0.03) | possibly_damaging(0.801) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RSPH9 | SNV | Missense_Mutation | novel | c.80N>T | p.Ser27Leu | p.S27L | Q9H1X1 | protein_coding | tolerated(0.24) | possibly_damaging(0.539) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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