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Gene: RPS6KC1 |
Gene summary for RPS6KC1 |
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Gene information | Species | Human | Gene symbol | RPS6KC1 | Gene ID | 26750 |
Gene name | ribosomal protein S6 kinase C1 | |
Gene Alias | RPK118 | |
Cytomap | 1q32.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q96S38 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26750 | RPS6KC1 | CCI_1 | Human | Cervix | CC | 4.83e-09 | 1.07e+00 | 0.528 |
26750 | RPS6KC1 | CCI_2 | Human | Cervix | CC | 3.31e-04 | 5.06e-01 | 0.5249 |
26750 | RPS6KC1 | CCI_3 | Human | Cervix | CC | 4.90e-11 | 8.15e-01 | 0.516 |
26750 | RPS6KC1 | LZE4T | Human | Esophagus | ESCC | 2.21e-08 | 3.07e-01 | 0.0811 |
26750 | RPS6KC1 | LZE7T | Human | Esophagus | ESCC | 2.67e-07 | 2.56e-01 | 0.0667 |
26750 | RPS6KC1 | LZE24T | Human | Esophagus | ESCC | 2.21e-05 | 1.39e-01 | 0.0596 |
26750 | RPS6KC1 | LZE21T | Human | Esophagus | ESCC | 4.27e-04 | 2.66e-01 | 0.0655 |
26750 | RPS6KC1 | P1T-E | Human | Esophagus | ESCC | 2.08e-02 | 1.93e-01 | 0.0875 |
26750 | RPS6KC1 | P2T-E | Human | Esophagus | ESCC | 3.28e-14 | 2.65e-01 | 0.1177 |
26750 | RPS6KC1 | P4T-E | Human | Esophagus | ESCC | 8.30e-03 | 1.19e-01 | 0.1323 |
26750 | RPS6KC1 | P5T-E | Human | Esophagus | ESCC | 1.13e-10 | 2.24e-01 | 0.1327 |
26750 | RPS6KC1 | P8T-E | Human | Esophagus | ESCC | 4.40e-09 | 2.01e-01 | 0.0889 |
26750 | RPS6KC1 | P9T-E | Human | Esophagus | ESCC | 1.01e-13 | 3.57e-01 | 0.1131 |
26750 | RPS6KC1 | P10T-E | Human | Esophagus | ESCC | 2.03e-09 | 1.90e-01 | 0.116 |
26750 | RPS6KC1 | P11T-E | Human | Esophagus | ESCC | 1.85e-10 | 3.92e-01 | 0.1426 |
26750 | RPS6KC1 | P12T-E | Human | Esophagus | ESCC | 2.56e-16 | 2.94e-01 | 0.1122 |
26750 | RPS6KC1 | P15T-E | Human | Esophagus | ESCC | 9.37e-13 | 3.05e-01 | 0.1149 |
26750 | RPS6KC1 | P16T-E | Human | Esophagus | ESCC | 6.17e-12 | 3.50e-01 | 0.1153 |
26750 | RPS6KC1 | P17T-E | Human | Esophagus | ESCC | 1.36e-02 | 1.47e-01 | 0.1278 |
26750 | RPS6KC1 | P19T-E | Human | Esophagus | ESCC | 1.67e-04 | 3.35e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPS6KC1 | SNV | Missense_Mutation | c.2983C>G | p.Leu995Val | p.L995V | Q96S38 | protein_coding | deleterious(0.03) | probably_damaging(0.936) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RPS6KC1 | SNV | Missense_Mutation | rs577745586 | c.429N>G | p.His143Gln | p.H143Q | Q96S38 | protein_coding | tolerated(0.11) | benign(0.05) | TCGA-AC-A3TN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
RPS6KC1 | SNV | Missense_Mutation | novel | c.2629N>A | p.Glu877Lys | p.E877K | Q96S38 | protein_coding | tolerated(0.15) | benign(0.111) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
RPS6KC1 | SNV | Missense_Mutation | novel | c.551N>T | p.Ser184Phe | p.S184F | Q96S38 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A1F2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RPS6KC1 | SNV | Missense_Mutation | c.788N>G | p.Ser263Cys | p.S263C | Q96S38 | protein_coding | deleterious(0.01) | possibly_damaging(0.905) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
RPS6KC1 | SNV | Missense_Mutation | novel | c.1096N>G | p.Leu366Val | p.L366V | Q96S38 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-GM-A2DH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR |
RPS6KC1 | SNV | Missense_Mutation | novel | c.1606N>G | p.Lys536Glu | p.K536E | Q96S38 | protein_coding | tolerated(0.08) | benign(0.164) | TCGA-C5-A8YQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
RPS6KC1 | SNV | Missense_Mutation | rs752202818 | c.218G>A | p.Arg73Gln | p.R73Q | Q96S38 | protein_coding | tolerated(0.08) | benign(0.188) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RPS6KC1 | SNV | Missense_Mutation | novel | c.1564G>A | p.Glu522Lys | p.E522K | Q96S38 | protein_coding | deleterious(0) | benign(0.419) | TCGA-UC-A7PG-06 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD |
RPS6KC1 | SNV | Missense_Mutation | rs767587139 | c.2640N>T | p.Lys880Asn | p.K880N | Q96S38 | protein_coding | tolerated(0.05) | probably_damaging(0.936) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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