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Gene: RPP25L |
Gene summary for RPP25L |
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Gene information | Species | Human | Gene symbol | RPP25L | Gene ID | 138716 |
Gene name | ribonuclease P/MRP subunit p25 like | |
Gene Alias | C9orf23 | |
Cytomap | 9p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000966 | UniProtAcc | Q8N5L8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
138716 | RPP25L | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.57e-02 | 1.70e-01 | -0.1808 |
138716 | RPP25L | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.32e-04 | 2.25e-01 | -0.0811 |
138716 | RPP25L | HTA11_78_2000001011 | Human | Colorectum | AD | 6.31e-05 | 2.02e-01 | -0.1088 |
138716 | RPP25L | HTA11_347_2000001011 | Human | Colorectum | AD | 1.00e-10 | 2.51e-01 | -0.1954 |
138716 | RPP25L | HTA11_411_2000001011 | Human | Colorectum | SER | 2.74e-04 | 3.49e-01 | -0.2602 |
138716 | RPP25L | HTA11_696_2000001011 | Human | Colorectum | AD | 2.69e-07 | 2.43e-01 | -0.1464 |
138716 | RPP25L | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.69e-13 | 3.75e-01 | -0.059 |
138716 | RPP25L | HTA11_546_2000001011 | Human | Colorectum | AD | 3.62e-05 | 2.86e-01 | -0.0842 |
138716 | RPP25L | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.04e-02 | 2.69e-01 | -0.0179 |
138716 | RPP25L | HTA11_866_3004761011 | Human | Colorectum | AD | 1.69e-11 | 3.16e-01 | 0.096 |
138716 | RPP25L | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.41e-06 | 4.21e-01 | 0.0528 |
138716 | RPP25L | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.51e-03 | 2.45e-01 | -0.0177 |
138716 | RPP25L | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.29e-02 | 2.02e-01 | 0.0338 |
138716 | RPP25L | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.52e-10 | 2.74e-01 | 0.0674 |
138716 | RPP25L | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.02e-10 | 3.00e-01 | 0.294 |
138716 | RPP25L | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.99e-03 | 4.15e-01 | 0.3487 |
138716 | RPP25L | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.33e-12 | 4.09e-01 | 0.281 |
138716 | RPP25L | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.51e-13 | 3.43e-01 | 0.3859 |
138716 | RPP25L | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.35e-07 | 2.74e-01 | 0.3005 |
138716 | RPP25L | LZE4T | Human | Esophagus | ESCC | 2.81e-11 | 3.13e-01 | 0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034470 | Colorectum | MSI-H | ncRNA processing | 48/1319 | 395/18723 | 1.54e-04 | 4.47e-03 | 48 |
GO:0034660 | Colorectum | MSI-H | ncRNA metabolic process | 53/1319 | 485/18723 | 9.66e-04 | 1.68e-02 | 53 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00344713 | Esophagus | ESCC | ncRNA 5'-end processing | 18/8552 | 21/18723 | 1.81e-04 | 1.16e-03 | 18 |
GO:00009663 | Esophagus | ESCC | RNA 5'-end processing | 19/8552 | 23/18723 | 3.12e-04 | 1.85e-03 | 19 |
GO:00991163 | Esophagus | ESCC | tRNA 5'-end processing | 14/8552 | 16/18723 | 6.78e-04 | 3.56e-03 | 14 |
GO:00016823 | Esophagus | ESCC | tRNA 5'-leader removal | 11/8552 | 13/18723 | 4.76e-03 | 1.85e-02 | 11 |
GO:00344701 | Liver | Cirrhotic | ncRNA processing | 158/4634 | 395/18723 | 1.09e-11 | 6.96e-10 | 158 |
GO:00346603 | Liver | Cirrhotic | ncRNA metabolic process | 173/4634 | 485/18723 | 3.64e-08 | 1.21e-06 | 173 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:0008033 | Liver | HCC | tRNA processing | 87/7958 | 127/18723 | 2.66e-09 | 7.23e-08 | 87 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:0000966 | Liver | HCC | RNA 5'-end processing | 20/7958 | 23/18723 | 1.37e-05 | 1.51e-04 | 20 |
GO:0034471 | Liver | HCC | ncRNA 5'-end processing | 18/7958 | 21/18723 | 5.78e-05 | 5.34e-04 | 18 |
GO:0099116 | Liver | HCC | tRNA 5'-end processing | 14/7958 | 16/18723 | 2.73e-04 | 1.98e-03 | 14 |
GO:0001682 | Liver | HCC | tRNA 5'-leader removal | 11/7958 | 13/18723 | 2.38e-03 | 1.16e-02 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPP25L | SNV | Missense_Mutation | rs774126083 | c.376N>A | p.Leu126Met | p.L126M | Q8N5L8 | protein_coding | deleterious(0.03) | possibly_damaging(0.729) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
RPP25L | SNV | Missense_Mutation | novel | c.200N>T | p.Ala67Val | p.A67V | Q8N5L8 | protein_coding | deleterious(0) | possibly_damaging(0.843) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPP25L | deletion | Frame_Shift_Del | c.419delC | p.Pro140LeufsTer36 | p.P140Lfs*36 | Q8N5L8 | protein_coding | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
RPP25L | SNV | Missense_Mutation | novel | c.86N>A | p.Arg29Gln | p.R29Q | Q8N5L8 | protein_coding | tolerated(0.09) | possibly_damaging(0.495) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPP25L | SNV | Missense_Mutation | c.85N>T | p.Arg29Trp | p.R29W | Q8N5L8 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RPP25L | SNV | Missense_Mutation | rs768909511 | c.109N>T | p.Arg37Cys | p.R37C | Q8N5L8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPP25L | SNV | Missense_Mutation | novel | c.440N>T | p.Ser147Ile | p.S147I | Q8N5L8 | protein_coding | tolerated(0.13) | benign(0.005) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
RPP25L | SNV | Missense_Mutation | c.41N>T | p.Ala14Val | p.A14V | Q8N5L8 | protein_coding | tolerated(0.47) | benign(0.011) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RPP25L | SNV | Missense_Mutation | c.164T>C | p.Val55Ala | p.V55A | Q8N5L8 | protein_coding | deleterious(0) | benign(0.42) | TCGA-AP-A0LE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RPP25L | SNV | Missense_Mutation | rs768909511 | c.109N>T | p.Arg37Cys | p.R37C | Q8N5L8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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