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Gene: RPL9 |
Gene summary for RPL9 |
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Gene information | Species | Human | Gene symbol | RPL9 | Gene ID | 6133 |
Gene name | ribosomal protein L9 | |
Gene Alias | L9 | |
Cytomap | 4p14 | |
Gene Type | protein-coding | GO ID | GO:0002181 | UniProtAcc | P32969 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6133 | RPL9 | GSM4909281 | Human | Breast | IDC | 3.20e-41 | -2.88e-01 | 0.21 |
6133 | RPL9 | GSM4909282 | Human | Breast | IDC | 1.21e-65 | -3.94e-01 | -0.0288 |
6133 | RPL9 | GSM4909285 | Human | Breast | IDC | 1.52e-07 | -1.06e-01 | 0.21 |
6133 | RPL9 | GSM4909286 | Human | Breast | IDC | 1.51e-08 | 1.30e-01 | 0.1081 |
6133 | RPL9 | GSM4909287 | Human | Breast | IDC | 3.31e-48 | -5.12e-01 | 0.2057 |
6133 | RPL9 | GSM4909289 | Human | Breast | IDC | 2.90e-03 | -2.58e-01 | 0.1064 |
6133 | RPL9 | GSM4909290 | Human | Breast | IDC | 8.58e-48 | -4.47e-01 | 0.2096 |
6133 | RPL9 | GSM4909295 | Human | Breast | IDC | 6.94e-22 | -4.39e-01 | 0.0898 |
6133 | RPL9 | GSM4909296 | Human | Breast | IDC | 8.58e-40 | -4.08e-01 | 0.1524 |
6133 | RPL9 | GSM4909297 | Human | Breast | IDC | 1.07e-19 | -3.20e-01 | 0.1517 |
6133 | RPL9 | GSM4909301 | Human | Breast | IDC | 4.57e-49 | -3.77e-01 | 0.1577 |
6133 | RPL9 | GSM4909302 | Human | Breast | IDC | 6.48e-10 | -2.32e-01 | 0.1545 |
6133 | RPL9 | GSM4909304 | Human | Breast | IDC | 1.21e-05 | -8.55e-02 | 0.1636 |
6133 | RPL9 | GSM4909306 | Human | Breast | IDC | 9.17e-03 | -8.52e-02 | 0.1564 |
6133 | RPL9 | GSM4909307 | Human | Breast | IDC | 1.11e-28 | -2.40e-01 | 0.1569 |
6133 | RPL9 | GSM4909308 | Human | Breast | IDC | 1.04e-24 | -2.17e-01 | 0.158 |
6133 | RPL9 | GSM4909309 | Human | Breast | IDC | 1.28e-15 | -3.05e-01 | 0.0483 |
6133 | RPL9 | GSM4909311 | Human | Breast | IDC | 5.00e-20 | -3.83e-01 | 0.1534 |
6133 | RPL9 | GSM4909312 | Human | Breast | IDC | 1.61e-12 | -1.86e-01 | 0.1552 |
6133 | RPL9 | GSM4909313 | Human | Breast | IDC | 4.52e-11 | -2.12e-01 | 0.0391 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00021819 | Breast | Precancer | cytoplasmic translation | 80/1080 | 148/18723 | 1.59e-59 | 8.54e-56 | 80 |
GO:000218114 | Breast | IDC | cytoplasmic translation | 82/1434 | 148/18723 | 2.60e-52 | 1.48e-48 | 82 |
GO:000218124 | Breast | DCIS | cytoplasmic translation | 82/1390 | 148/18723 | 2.21e-53 | 1.25e-49 | 82 |
GO:000218110 | Cervix | CC | cytoplasmic translation | 96/2311 | 148/18723 | 4.87e-51 | 2.91e-47 | 96 |
GO:000218115 | Cervix | HSIL_HPV | cytoplasmic translation | 86/737 | 148/18723 | 3.97e-82 | 1.91e-78 | 86 |
GO:000218125 | Cervix | N_HPV | cytoplasmic translation | 42/534 | 148/18723 | 2.61e-30 | 1.19e-26 | 42 |
GO:0002181 | Colorectum | AD | cytoplasmic translation | 109/3918 | 148/18723 | 3.40e-43 | 2.13e-39 | 109 |
GO:00021811 | Colorectum | SER | cytoplasmic translation | 102/2897 | 148/18723 | 1.38e-48 | 8.49e-45 | 102 |
GO:00021812 | Colorectum | MSS | cytoplasmic translation | 108/3467 | 148/18723 | 1.78e-47 | 1.11e-43 | 108 |
GO:00021813 | Colorectum | MSI-H | cytoplasmic translation | 100/1319 | 148/18723 | 1.50e-79 | 8.31e-76 | 100 |
GO:000218116 | Endometrium | AEH | cytoplasmic translation | 104/2100 | 148/18723 | 1.01e-64 | 6.07e-61 | 104 |
GO:000218117 | Endometrium | EEC | cytoplasmic translation | 104/2168 | 148/18723 | 2.53e-63 | 1.52e-59 | 104 |
GO:000218127 | Esophagus | HGIN | cytoplasmic translation | 108/2587 | 148/18723 | 1.70e-60 | 1.02e-56 | 108 |
GO:0002181111 | Esophagus | ESCC | cytoplasmic translation | 135/8552 | 148/18723 | 4.17e-32 | 2.65e-29 | 135 |
GO:00021817 | Liver | NAFLD | cytoplasmic translation | 93/1882 | 148/18723 | 1.44e-55 | 8.41e-52 | 93 |
GO:000218112 | Liver | Cirrhotic | cytoplasmic translation | 120/4634 | 148/18723 | 2.95e-47 | 1.85e-43 | 120 |
GO:000218122 | Liver | HCC | cytoplasmic translation | 132/7958 | 148/18723 | 9.09e-33 | 5.76e-30 | 132 |
GO:000218132 | Liver | Cyst | cytoplasmic translation | 70/496 | 148/18723 | 9.01e-71 | 3.85e-67 | 70 |
GO:00021818 | Lung | IAC | cytoplasmic translation | 85/2061 | 148/18723 | 3.11e-43 | 1.85e-39 | 85 |
GO:000218113 | Lung | AIS | cytoplasmic translation | 85/1849 | 148/18723 | 5.48e-47 | 3.19e-43 | 85 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301018 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0517118 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301019 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0517119 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301024 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517124 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301034 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517134 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301044 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517144 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0301054 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517154 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0301020 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa05171110 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa03010110 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa0301025 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517125 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa0301035 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517135 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPL9 | SNV | Missense_Mutation | novel | c.526T>G | p.Leu176Val | p.L176V | P32969 | protein_coding | deleterious(0.01) | possibly_damaging(0.539) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPL9 | SNV | Missense_Mutation | c.212N>A | p.Arg71Gln | p.R71Q | P32969 | protein_coding | deleterious(0.03) | benign(0.167) | TCGA-OL-A66P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR | |
RPL9 | SNV | Missense_Mutation | c.337N>A | p.Glu113Lys | p.E113K | P32969 | protein_coding | deleterious(0.01) | possibly_damaging(0.588) | TCGA-FU-A3HY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
RPL9 | SNV | Missense_Mutation | novel | c.412C>G | p.Gln138Glu | p.Q138E | P32969 | protein_coding | tolerated(0.31) | benign(0.035) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RPL9 | SNV | Missense_Mutation | c.344N>A | p.Arg115Gln | p.R115Q | P32969 | protein_coding | tolerated(0.12) | benign(0.273) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
RPL9 | SNV | Missense_Mutation | novel | c.26N>G | p.Thr9Ser | p.T9S | P32969 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPL9 | SNV | Missense_Mutation | rs751277956 | c.124N>G | p.Asn42Asp | p.N42D | P32969 | protein_coding | tolerated(0.25) | benign(0.03) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RPL9 | insertion | In_Frame_Ins | novel | c.27_28insAAT | p.Thr9_Val10insAsn | p.T9_V10insN | P32969 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RPL9 | SNV | Missense_Mutation | novel | c.413N>G | p.Gln138Arg | p.Q138R | P32969 | protein_coding | tolerated(0.06) | benign(0.033) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPL9 | SNV | Missense_Mutation | novel | c.568G>A | p.Ala190Thr | p.A190T | P32969 | protein_coding | tolerated(0.28) | benign(0) | TCGA-A5-A7WJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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