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Gene: RPL7L1 |
Gene summary for RPL7L1 |
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Gene information | Species | Human | Gene symbol | RPL7L1 | Gene ID | 285855 |
Gene name | ribosomal protein L7 like 1 | |
Gene Alias | dJ475N16.4 | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0000463 | UniProtAcc | A0A024RD36 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285855 | RPL7L1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.19e-09 | 5.62e-01 | -0.0811 |
285855 | RPL7L1 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.91e-05 | 3.59e-01 | -0.1088 |
285855 | RPL7L1 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.28e-12 | 5.08e-01 | -0.1954 |
285855 | RPL7L1 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.26e-08 | 4.90e-01 | -0.1526 |
285855 | RPL7L1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.20e-02 | 3.38e-01 | -0.1464 |
285855 | RPL7L1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.94e-11 | 5.38e-01 | -0.059 |
285855 | RPL7L1 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.85e-03 | 2.82e-01 | 0.096 |
285855 | RPL7L1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.99e-04 | 5.94e-01 | 0.0131 |
285855 | RPL7L1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.73e-09 | 4.07e-01 | 0.0674 |
285855 | RPL7L1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 7.11e-05 | 1.16e+00 | 0.3487 |
285855 | RPL7L1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 6.57e-15 | 7.82e-01 | 0.281 |
285855 | RPL7L1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.70e-17 | 7.04e-01 | 0.3859 |
285855 | RPL7L1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 6.07e-03 | 4.32e-01 | 0.2585 |
285855 | RPL7L1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.48e-05 | 3.60e-01 | 0.3005 |
285855 | RPL7L1 | A015-C-203 | Human | Colorectum | FAP | 1.38e-03 | -3.24e-02 | -0.1294 |
285855 | RPL7L1 | A015-C-104 | Human | Colorectum | FAP | 2.71e-04 | 2.70e-03 | -0.1899 |
285855 | RPL7L1 | AEH-subject1 | Human | Endometrium | AEH | 1.79e-22 | -3.74e-01 | -0.3059 |
285855 | RPL7L1 | AEH-subject2 | Human | Endometrium | AEH | 4.43e-05 | -2.72e-01 | -0.2525 |
285855 | RPL7L1 | AEH-subject3 | Human | Endometrium | AEH | 3.53e-14 | -2.86e-01 | -0.2576 |
285855 | RPL7L1 | AEH-subject4 | Human | Endometrium | AEH | 2.35e-07 | -3.31e-01 | -0.2657 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
GO:0001701 | Colorectum | AD | in utero embryonic development | 110/3918 | 367/18723 | 2.36e-05 | 4.62e-04 | 110 |
GO:0042273 | Colorectum | AD | ribosomal large subunit biogenesis | 28/3918 | 72/18723 | 3.74e-04 | 4.31e-03 | 28 |
GO:0042254 | Colorectum | AD | ribosome biogenesis | 84/3918 | 299/18723 | 1.82e-03 | 1.50e-02 | 84 |
GO:00226131 | Colorectum | SER | ribonucleoprotein complex biogenesis | 112/2897 | 463/18723 | 5.01e-07 | 2.48e-05 | 112 |
GO:00422731 | Colorectum | SER | ribosomal large subunit biogenesis | 23/2897 | 72/18723 | 3.60e-04 | 5.61e-03 | 23 |
GO:00422541 | Colorectum | SER | ribosome biogenesis | 66/2897 | 299/18723 | 1.48e-03 | 1.60e-02 | 66 |
GO:00017011 | Colorectum | SER | in utero embryonic development | 77/2897 | 367/18723 | 2.77e-03 | 2.48e-02 | 77 |
GO:00226132 | Colorectum | MSS | ribonucleoprotein complex biogenesis | 144/3467 | 463/18723 | 2.76e-11 | 3.67e-09 | 144 |
GO:00017012 | Colorectum | MSS | in utero embryonic development | 99/3467 | 367/18723 | 3.71e-05 | 7.10e-04 | 99 |
GO:00422732 | Colorectum | MSS | ribosomal large subunit biogenesis | 28/3467 | 72/18723 | 4.16e-05 | 7.83e-04 | 28 |
GO:00422542 | Colorectum | MSS | ribosome biogenesis | 79/3467 | 299/18723 | 4.32e-04 | 5.23e-03 | 79 |
GO:0000470 | Colorectum | MSS | maturation of LSU-rRNA | 12/3467 | 28/18723 | 2.53e-03 | 2.02e-02 | 12 |
GO:0006364 | Colorectum | MSS | rRNA processing | 58/3467 | 225/18723 | 4.17e-03 | 3.03e-02 | 58 |
GO:0016072 | Colorectum | MSS | rRNA metabolic process | 60/3467 | 236/18723 | 5.01e-03 | 3.46e-02 | 60 |
GO:00226133 | Colorectum | MSI-H | ribonucleoprotein complex biogenesis | 95/1319 | 463/18723 | 1.04e-21 | 8.32e-19 | 95 |
GO:00422543 | Colorectum | MSI-H | ribosome biogenesis | 54/1319 | 299/18723 | 1.27e-10 | 2.07e-08 | 54 |
GO:00422733 | Colorectum | MSI-H | ribosomal large subunit biogenesis | 23/1319 | 72/18723 | 3.58e-10 | 5.23e-08 | 23 |
GO:00063641 | Colorectum | MSI-H | rRNA processing | 39/1319 | 225/18723 | 1.45e-07 | 1.32e-05 | 39 |
GO:00160721 | Colorectum | MSI-H | rRNA metabolic process | 39/1319 | 236/18723 | 5.20e-07 | 3.91e-05 | 39 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPL7L1 | SNV | Missense_Mutation | c.341G>T | p.Arg114Ile | p.R114I | Q6DKI1 | protein_coding | deleterious(0) | possibly_damaging(0.495) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
RPL7L1 | SNV | Missense_Mutation | c.494G>C | p.Gly165Ala | p.G165A | Q6DKI1 | protein_coding | deleterious(0.01) | possibly_damaging(0.782) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
RPL7L1 | SNV | Missense_Mutation | novel | c.270N>C | p.Leu90Phe | p.L90F | Q6DKI1 | protein_coding | deleterious(0.04) | benign(0.361) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RPL7L1 | SNV | Missense_Mutation | novel | c.372N>G | p.Ile124Met | p.I124M | Q6DKI1 | protein_coding | deleterious(0.02) | benign(0.277) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPL7L1 | SNV | Missense_Mutation | novel | c.230G>C | p.Arg77Pro | p.R77P | Q6DKI1 | protein_coding | deleterious(0.01) | possibly_damaging(0.809) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPL7L1 | SNV | Missense_Mutation | rs377107940 | c.422N>A | p.Arg141His | p.R141H | Q6DKI1 | protein_coding | tolerated(0.06) | benign(0.021) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPL7L1 | insertion | Frame_Shift_Ins | novel | c.397_398insC | p.Gln135ProfsTer38 | p.Q135Pfs*38 | Q6DKI1 | protein_coding | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
RPL7L1 | deletion | Frame_Shift_Del | novel | c.233delT | p.Leu78ProfsTer4 | p.L78Pfs*4 | Q6DKI1 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RPL7L1 | SNV | Missense_Mutation | rs191520270 | c.301N>T | p.Arg101Cys | p.R101C | Q6DKI1 | protein_coding | tolerated(0.06) | benign(0.031) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RPL7L1 | SNV | Missense_Mutation | c.630N>C | p.Glu210Asp | p.E210D | Q6DKI1 | protein_coding | tolerated(0.09) | benign(0.005) | TCGA-AJ-A3BD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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