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Gene: RPL19 |
Gene summary for RPL19 |
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Gene information | Species | Human | Gene symbol | RPL19 | Gene ID | 6143 |
Gene name | ribosomal protein L19 | |
Gene Alias | L19 | |
Cytomap | 17q12 | |
Gene Type | protein-coding | GO ID | GO:0001889 | UniProtAcc | P84098 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6143 | RPL19 | GSM4909280 | Human | Breast | Precancer | 1.38e-03 | -3.59e-01 | 0.0305 |
6143 | RPL19 | GSM4909281 | Human | Breast | IDC | 8.22e-20 | -2.28e-01 | 0.21 |
6143 | RPL19 | GSM4909282 | Human | Breast | IDC | 2.16e-59 | -3.62e-01 | -0.0288 |
6143 | RPL19 | GSM4909285 | Human | Breast | IDC | 2.03e-05 | -1.09e-01 | 0.21 |
6143 | RPL19 | GSM4909286 | Human | Breast | IDC | 3.01e-70 | 2.67e-01 | 0.1081 |
6143 | RPL19 | GSM4909287 | Human | Breast | IDC | 2.78e-37 | -4.11e-01 | 0.2057 |
6143 | RPL19 | GSM4909289 | Human | Breast | IDC | 1.62e-15 | 2.90e-01 | 0.1064 |
6143 | RPL19 | GSM4909290 | Human | Breast | IDC | 2.67e-31 | -3.47e-01 | 0.2096 |
6143 | RPL19 | GSM4909291 | Human | Breast | IDC | 1.48e-126 | 5.52e-01 | 0.1753 |
6143 | RPL19 | GSM4909292 | Human | Breast | IDC | 3.34e-37 | 4.89e-01 | 0.1236 |
6143 | RPL19 | GSM4909293 | Human | Breast | IDC | 4.61e-120 | 4.88e-01 | 0.1581 |
6143 | RPL19 | GSM4909294 | Human | Breast | IDC | 1.52e-133 | 4.39e-01 | 0.2022 |
6143 | RPL19 | GSM4909296 | Human | Breast | IDC | 9.77e-04 | -1.56e-01 | 0.1524 |
6143 | RPL19 | GSM4909297 | Human | Breast | IDC | 5.24e-04 | -1.66e-01 | 0.1517 |
6143 | RPL19 | GSM4909298 | Human | Breast | IDC | 3.09e-17 | -1.62e-01 | 0.1551 |
6143 | RPL19 | GSM4909304 | Human | Breast | IDC | 1.30e-23 | -1.88e-01 | 0.1636 |
6143 | RPL19 | GSM4909307 | Human | Breast | IDC | 4.09e-11 | 1.24e-01 | 0.1569 |
6143 | RPL19 | GSM4909308 | Human | Breast | IDC | 1.82e-05 | 8.34e-02 | 0.158 |
6143 | RPL19 | GSM4909311 | Human | Breast | IDC | 8.60e-08 | -3.68e-02 | 0.1534 |
6143 | RPL19 | GSM4909315 | Human | Breast | IDC | 2.58e-11 | -2.12e-01 | 0.21 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00021819 | Breast | Precancer | cytoplasmic translation | 80/1080 | 148/18723 | 1.59e-59 | 8.54e-56 | 80 |
GO:00487329 | Breast | Precancer | gland development | 49/1080 | 436/18723 | 6.11e-06 | 1.73e-04 | 49 |
GO:00974216 | Breast | Precancer | liver regeneration | 10/1080 | 35/18723 | 1.91e-05 | 4.52e-04 | 10 |
GO:00311004 | Breast | Precancer | animal organ regeneration | 14/1080 | 76/18723 | 9.92e-05 | 1.83e-03 | 14 |
GO:00018898 | Breast | Precancer | liver development | 21/1080 | 147/18723 | 1.08e-04 | 1.96e-03 | 21 |
GO:00610088 | Breast | Precancer | hepaticobiliary system development | 21/1080 | 150/18723 | 1.45e-04 | 2.49e-03 | 21 |
GO:00310995 | Breast | Precancer | regeneration | 25/1080 | 198/18723 | 1.91e-04 | 3.06e-03 | 25 |
GO:000218114 | Breast | IDC | cytoplasmic translation | 82/1434 | 148/18723 | 2.60e-52 | 1.48e-48 | 82 |
GO:004873214 | Breast | IDC | gland development | 64/1434 | 436/18723 | 3.47e-07 | 1.74e-05 | 64 |
GO:003110012 | Breast | IDC | animal organ regeneration | 17/1434 | 76/18723 | 4.85e-05 | 1.07e-03 | 17 |
GO:003109912 | Breast | IDC | regeneration | 31/1434 | 198/18723 | 1.08e-04 | 2.03e-03 | 31 |
GO:009742112 | Breast | IDC | liver regeneration | 10/1434 | 35/18723 | 2.09e-04 | 3.41e-03 | 10 |
GO:000188913 | Breast | IDC | liver development | 24/1434 | 147/18723 | 3.29e-04 | 4.92e-03 | 24 |
GO:006100813 | Breast | IDC | hepaticobiliary system development | 24/1434 | 150/18723 | 4.46e-04 | 6.04e-03 | 24 |
GO:000218124 | Breast | DCIS | cytoplasmic translation | 82/1390 | 148/18723 | 2.21e-53 | 1.25e-49 | 82 |
GO:004873223 | Breast | DCIS | gland development | 60/1390 | 436/18723 | 2.50e-06 | 8.74e-05 | 60 |
GO:003110022 | Breast | DCIS | animal organ regeneration | 16/1390 | 76/18723 | 1.20e-04 | 2.09e-03 | 16 |
GO:003109921 | Breast | DCIS | regeneration | 30/1390 | 198/18723 | 1.45e-04 | 2.47e-03 | 30 |
GO:000188923 | Breast | DCIS | liver development | 23/1390 | 147/18723 | 5.21e-04 | 6.76e-03 | 23 |
GO:006100823 | Breast | DCIS | hepaticobiliary system development | 23/1390 | 150/18723 | 6.96e-04 | 8.47e-03 | 23 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301018 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0517118 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301019 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0517119 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301024 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517124 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301034 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517134 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301044 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517144 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0301054 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517154 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0301020 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa05171110 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa03010110 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa0301025 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517125 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa0301035 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517135 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPL19 | SNV | Missense_Mutation | c.320G>A | p.Arg107Lys | p.R107K | P84098 | protein_coding | tolerated(0.29) | benign(0.011) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
RPL19 | SNV | Missense_Mutation | c.24N>C | p.Lys8Asn | p.K8N | P84098 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-D8-A1J9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RPL19 | SNV | Missense_Mutation | novel | c.277G>T | p.Val93Phe | p.V93F | P84098 | protein_coding | deleterious(0.04) | benign(0.024) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
RPL19 | insertion | Frame_Shift_Ins | novel | c.574_575insTCCTCCTGAGGTGGTACGACCC | p.Glu192ValfsTer34 | p.E192Vfs*34 | P84098 | protein_coding | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD | ||
RPL19 | SNV | Missense_Mutation | novel | c.407N>A | p.Arg136Gln | p.R136Q | P84098 | protein_coding | tolerated(0.09) | benign(0.034) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RPL19 | SNV | Missense_Mutation | novel | c.577N>A | p.Glu193Lys | p.E193K | P84098 | protein_coding | deleterious(0.04) | probably_damaging(0.912) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
RPL19 | SNV | Missense_Mutation | c.184C>G | p.Arg62Gly | p.R62G | P84098 | protein_coding | deleterious(0.02) | benign(0.127) | TCGA-VS-A9UY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
RPL19 | SNV | Missense_Mutation | rs11554156 | c.412N>T | p.Leu138Phe | p.L138F | P84098 | protein_coding | deleterious(0.04) | possibly_damaging(0.658) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPL19 | SNV | Missense_Mutation | c.314T>A | p.Leu105Gln | p.L105Q | P84098 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RPL19 | SNV | Missense_Mutation | rs773243876 | c.350N>A | p.Arg117His | p.R117H | P84098 | protein_coding | tolerated(0.22) | benign(0.009) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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