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Gene: RPL18A |
Gene summary for RPL18A |
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Gene information | Species | Human | Gene symbol | RPL18A | Gene ID | 6142 |
Gene name | ribosomal protein L18a | |
Gene Alias | L18A | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0002181 | UniProtAcc | Q02543 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6142 | RPL18A | GSM4909277 | Human | Breast | Precancer | 2.01e-02 | -4.43e-01 | 0.0177 |
6142 | RPL18A | GSM4909280 | Human | Breast | Precancer | 1.84e-04 | -4.42e-01 | 0.0305 |
6142 | RPL18A | GSM4909281 | Human | Breast | IDC | 1.60e-30 | -2.60e-01 | 0.21 |
6142 | RPL18A | GSM4909282 | Human | Breast | IDC | 2.69e-05 | -9.48e-02 | -0.0288 |
6142 | RPL18A | GSM4909285 | Human | Breast | IDC | 3.51e-33 | 2.17e-01 | 0.21 |
6142 | RPL18A | GSM4909286 | Human | Breast | IDC | 4.71e-07 | 1.11e-01 | 0.1081 |
6142 | RPL18A | GSM4909296 | Human | Breast | IDC | 1.09e-13 | 1.35e-01 | 0.1524 |
6142 | RPL18A | GSM4909297 | Human | Breast | IDC | 1.04e-14 | -2.35e-01 | 0.1517 |
6142 | RPL18A | GSM4909298 | Human | Breast | IDC | 2.37e-07 | -8.52e-02 | 0.1551 |
6142 | RPL18A | GSM4909299 | Human | Breast | IDC | 5.27e-05 | -8.49e-02 | 0.035 |
6142 | RPL18A | GSM4909301 | Human | Breast | IDC | 2.48e-06 | -1.19e-01 | 0.1577 |
6142 | RPL18A | GSM4909306 | Human | Breast | IDC | 1.20e-18 | -1.61e-01 | 0.1564 |
6142 | RPL18A | GSM4909313 | Human | Breast | IDC | 2.08e-03 | -1.53e-01 | 0.0391 |
6142 | RPL18A | GSM4909315 | Human | Breast | IDC | 5.11e-10 | 1.30e-01 | 0.21 |
6142 | RPL18A | GSM4909317 | Human | Breast | IDC | 4.02e-14 | -2.23e-01 | 0.1355 |
6142 | RPL18A | GSM4909318 | Human | Breast | IDC | 5.52e-03 | -2.88e-01 | 0.2031 |
6142 | RPL18A | GSM4909319 | Human | Breast | IDC | 4.49e-24 | -4.22e-01 | 0.1563 |
6142 | RPL18A | brca2 | Human | Breast | Precancer | 4.37e-18 | -1.41e-01 | -0.024 |
6142 | RPL18A | brca3 | Human | Breast | Precancer | 2.42e-04 | -5.42e-02 | -0.0263 |
6142 | RPL18A | M2 | Human | Breast | IDC | 1.47e-07 | -4.03e-01 | 0.21 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00021819 | Breast | Precancer | cytoplasmic translation | 80/1080 | 148/18723 | 1.59e-59 | 8.54e-56 | 80 |
GO:000218114 | Breast | IDC | cytoplasmic translation | 82/1434 | 148/18723 | 2.60e-52 | 1.48e-48 | 82 |
GO:000218124 | Breast | DCIS | cytoplasmic translation | 82/1390 | 148/18723 | 2.21e-53 | 1.25e-49 | 82 |
GO:000218110 | Cervix | CC | cytoplasmic translation | 96/2311 | 148/18723 | 4.87e-51 | 2.91e-47 | 96 |
GO:000218115 | Cervix | HSIL_HPV | cytoplasmic translation | 86/737 | 148/18723 | 3.97e-82 | 1.91e-78 | 86 |
GO:0002181 | Colorectum | AD | cytoplasmic translation | 109/3918 | 148/18723 | 3.40e-43 | 2.13e-39 | 109 |
GO:00021811 | Colorectum | SER | cytoplasmic translation | 102/2897 | 148/18723 | 1.38e-48 | 8.49e-45 | 102 |
GO:00021812 | Colorectum | MSS | cytoplasmic translation | 108/3467 | 148/18723 | 1.78e-47 | 1.11e-43 | 108 |
GO:00021813 | Colorectum | MSI-H | cytoplasmic translation | 100/1319 | 148/18723 | 1.50e-79 | 8.31e-76 | 100 |
GO:000218116 | Endometrium | AEH | cytoplasmic translation | 104/2100 | 148/18723 | 1.01e-64 | 6.07e-61 | 104 |
GO:000218117 | Endometrium | EEC | cytoplasmic translation | 104/2168 | 148/18723 | 2.53e-63 | 1.52e-59 | 104 |
GO:000218127 | Esophagus | HGIN | cytoplasmic translation | 108/2587 | 148/18723 | 1.70e-60 | 1.02e-56 | 108 |
GO:0002181111 | Esophagus | ESCC | cytoplasmic translation | 135/8552 | 148/18723 | 4.17e-32 | 2.65e-29 | 135 |
GO:00021817 | Liver | NAFLD | cytoplasmic translation | 93/1882 | 148/18723 | 1.44e-55 | 8.41e-52 | 93 |
GO:000218112 | Liver | Cirrhotic | cytoplasmic translation | 120/4634 | 148/18723 | 2.95e-47 | 1.85e-43 | 120 |
GO:000218122 | Liver | HCC | cytoplasmic translation | 132/7958 | 148/18723 | 9.09e-33 | 5.76e-30 | 132 |
GO:000218132 | Liver | Cyst | cytoplasmic translation | 70/496 | 148/18723 | 9.01e-71 | 3.85e-67 | 70 |
GO:00021818 | Lung | IAC | cytoplasmic translation | 85/2061 | 148/18723 | 3.11e-43 | 1.85e-39 | 85 |
GO:000218113 | Lung | AIS | cytoplasmic translation | 85/1849 | 148/18723 | 5.48e-47 | 3.19e-43 | 85 |
GO:000218123 | Lung | AAH | cytoplasmic translation | 64/613 | 148/18723 | 1.74e-55 | 7.99e-52 | 64 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0517118 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0517119 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301024 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517124 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301034 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517134 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301044 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517144 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0301054 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517154 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0301020 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa05171110 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa03010110 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa0301025 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517125 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa0301035 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517135 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa03010 | Colorectum | AD | Ribosome | 96/2092 | 167/8465 | 8.28e-20 | 5.54e-18 | 3.54e-18 | 96 |
hsa05171 | Colorectum | AD | Coronavirus disease - COVID-19 | 113/2092 | 232/8465 | 9.90e-16 | 2.55e-14 | 1.63e-14 | 113 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPL18A | SNV | Missense_Mutation | c.496N>T | p.Arg166Cys | p.R166C | Q02543 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-A2-A0SW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | arimidex | PD | |
RPL18A | SNV | Missense_Mutation | rs565769311 | c.248G>A | p.Arg83His | p.R83H | Q02543 | protein_coding | tolerated(0.07) | benign(0.114) | TCGA-C8-A27B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
RPL18A | SNV | Missense_Mutation | novel | c.284N>A | p.Arg95Gln | p.R95Q | Q02543 | protein_coding | deleterious(0.05) | benign(0.2) | TCGA-LQ-A4E4-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | PD |
RPL18A | SNV | Missense_Mutation | novel | c.127C>T | p.Arg43Cys | p.R43C | Q02543 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RPL18A | SNV | Missense_Mutation | c.266N>A | p.Gly89Asp | p.G89D | Q02543 | protein_coding | deleterious(0.03) | benign(0.424) | TCGA-CK-5914-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
RPL18A | SNV | Missense_Mutation | rs776258482 | c.247N>T | p.Arg83Cys | p.R83C | Q02543 | protein_coding | deleterious(0.05) | benign(0.164) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPL18A | SNV | Missense_Mutation | novel | c.104C>A | p.Pro35His | p.P35H | Q02543 | protein_coding | deleterious(0) | benign(0.439) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RPL18A | SNV | Missense_Mutation | novel | c.457N>T | p.Pro153Ser | p.P153S | Q02543 | protein_coding | deleterious(0) | possibly_damaging(0.901) | TCGA-A5-A0GW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPL18A | SNV | Missense_Mutation | rs781670507 | c.398N>T | p.Ala133Val | p.A133V | Q02543 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPL18A | SNV | Missense_Mutation | rs772151051 | c.121N>G | p.Lys41Glu | p.K41E | Q02543 | protein_coding | deleterious(0.02) | probably_damaging(0.954) | TCGA-AP-A0LS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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