Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: RORC

Gene summary for RORC

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

RORC

Gene ID

6097

Gene nameRAR related orphan receptor C
Gene AliasIMD42
Cytomap1q21.3
Gene Typeprotein-coding
GO ID

GO:0000122

UniProtAcc

F1D8P6


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
6097RORCS43HumanLiverCirrhotic6.02e-06-1.12e-01-0.0187
6097RORCHCC1_MengHumanLiverHCC1.07e-04-1.37e-010.0246
6097RORCHCC2_MengHumanLiverHCC3.96e-02-9.26e-020.0107
6097RORCHCC2HumanLiverHCC1.03e-051.97e+000.5341
6097RORCS014HumanLiverHCC2.68e-044.78e-010.2254
6097RORCS016HumanLiverHCC1.78e-075.34e-010.2243
6097RORCS027HumanLiverHCC3.02e-024.97e-010.2446
6097RORCS028HumanLiverHCC3.18e-075.05e-010.2503
6097RORCS029HumanLiverHCC1.02e-077.04e-010.2581
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:000820211LiverCirrhoticsteroid metabolic process143/4634319/187232.79e-153.18e-13143
GO:000599612LiverCirrhoticmonosaccharide metabolic process104/4634257/187231.74e-086.32e-07104
GO:001931812LiverCirrhotichexose metabolic process97/4634237/187232.67e-089.16e-0797
GO:003052212LiverCirrhoticintracellular receptor signaling pathway105/4634265/187235.44e-081.69e-06105
GO:000941012LiverCirrhoticresponse to xenobiotic stimulus165/4634462/187236.82e-082.09e-06165
GO:000600611LiverCirrhoticglucose metabolic process82/4634196/187231.01e-072.93e-0682
GO:006201212LiverCirrhoticregulation of small molecule metabolic process124/4634334/187232.74e-076.79e-06124
GO:000762312LiverCirrhoticcircadian rhythm84/4634210/187237.04e-071.50e-0584
GO:001921611LiverCirrhoticregulation of lipid metabolic process119/4634331/187233.05e-065.39e-05119
GO:00329221LiverCirrhoticcircadian regulation of gene expression34/463468/187236.04e-069.74e-0534
GO:000610911LiverCirrhoticregulation of carbohydrate metabolic process70/4634178/187231.14e-051.62e-0470
GO:00192181LiverCirrhoticregulation of steroid metabolic process44/4634100/187231.97e-052.62e-0444
GO:004851111LiverCirrhoticrhythmic process103/4634298/187238.47e-059.19e-04103
GO:00714661LiverCirrhoticcellular response to xenobiotic stimulus66/4634177/187231.34e-041.31e-0366
GO:004426211LiverCirrhoticcellular carbohydrate metabolic process97/4634283/187231.89e-041.76e-0397
GO:00109061LiverCirrhoticregulation of glucose metabolic process47/4634119/187232.61e-042.33e-0347
GO:00106751LiverCirrhoticregulation of cellular carbohydrate metabolic process54/4634146/187236.53e-044.96e-0354
GO:000680511LiverCirrhoticxenobiotic metabolic process43/4634111/187237.51e-045.54e-0343
GO:00427525LiverCirrhoticregulation of circadian rhythm45/4634121/187231.55e-031.01e-0245
GO:0036314LiverCirrhoticresponse to sterol17/463436/187232.82e-031.63e-0217
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
RORCSTMBreastPrecancerMAOB,HSP90AA1,SP6, etc.2.22e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
RORCCD4TNCervixN_HPVTNFRSF25,IL23R,KLRB1, etc.2.60e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
RORCTREGEndometriumADJIL23R,IL4I1,AQP3, etc.7.29e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
RORCTFHEndometriumADJIL23R,IL4I1,AQP3, etc.8.15e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
RORCTH17EndometriumADJIL23R,IL4I1,AQP3, etc.8.74e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
RORCTH17EndometriumAEHIL23R,IL4I1,AQP3, etc.1.22e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
RORCCD4TNEndometriumHealthyIL23R,IL4I1,AQP3, etc.1.56e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
RORCLYMENDLiverCirrhoticCDO1,ZNF211,RAB33B, etc.4.56e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
RORCLYMENDLiverHealthyCDO1,ZNF211,RAB33B, etc.1.48e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
RORCLYMENDLiverNAFLDCDO1,ZNF211,RAB33B, etc.1.66e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
RORCSNVMissense_Mutationrs368067137c.1183G>Ap.Glu395Lysp.E395KP51449protein_codingdeleterious(0)benign(0.191)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
RORCSNVMissense_Mutationc.502G>Ap.Glu168Lysp.E168KP51449protein_codingtolerated(0.21)possibly_damaging(0.694)TCGA-AN-A04D-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
RORCSNVMissense_Mutationc.40N>Ap.Glu14Lysp.E14KP51449protein_codingtolerated(0.19)benign(0.015)TCGA-AR-A0TT-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydoxorubicinSD
RORCSNVMissense_Mutationnovelc.1483N>Ap.Gln495Lysp.Q495KP51449protein_codingtolerated(0.31)benign(0.084)TCGA-AR-A1AP-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyanastrozoleSD
RORCSNVMissense_Mutationrs866433322c.847N>Ap.Glu283Lysp.E283KP51449protein_codingdeleterious(0)benign(0.036)TCGA-BH-A18F-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereCR
RORCinsertionNonsense_Mutationnovelc.867_868insTAAGATTTTAACAGGCATTCATGGGGGTGGGGCAGGCATTCGp.Leu289_Glu290insTerp.L289_E290ins*P51449protein_codingTCGA-A8-A07G-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapy5-fluorouracilCR
RORCSNVMissense_Mutationnovelc.427G>Ap.Gly143Argp.G143RP51449protein_codingtolerated(0.37)benign(0.067)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
RORCSNVMissense_Mutationc.1303N>Cp.Glu435Glnp.E435QP51449protein_codingdeleterious(0)probably_damaging(0.957)TCGA-C5-A1MH-01Cervixcervical & endocervical cancerFemale>=65III/IVChemotherapycisplatinPD
RORCSNVMissense_Mutationnovelc.313N>Tp.Arg105Cysp.R105CP51449protein_codingdeleterious(0)probably_damaging(0.999)TCGA-EA-A410-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
RORCSNVMissense_Mutationrs546157871c.278N>Tp.Ala93Valp.A93VP51449protein_codingdeleterious(0)probably_damaging(0.981)TCGA-5M-AAT6-01Colorectumcolon adenocarcinomaFemale<65III/IVUnknownUnknownPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
6097RORCDRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTORDOMIPHEN BROMIDEDOMIPHEN BROMIDE
6097RORCDRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTORANDROSTENEDIONEANDROSTENEDIONE
6097RORCDRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTORTESTOSTERONETESTOSTERONE
6097RORCDRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTORVTP-43742
6097RORCDRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTORCARMINECARMINE
6097RORCDRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTORagonist348353620
6097RORCDRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTORFLUTAMIDEFLUTAMIDE
6097RORCDRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTORRHEINRHEIN
6097RORCDRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTORTAK-828
6097RORCDRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTORBBI-6000
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