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Gene: RNPEPL1 |
Gene summary for RNPEPL1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | RNPEPL1 | Gene ID | 57140 |
Gene name | arginyl aminopeptidase like 1 | |
Gene Alias | RNPEPL1 | |
Cytomap | 2q37.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q9HAU8 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57140 | RNPEPL1 | LZE7T | Human | Esophagus | ESCC | 4.16e-02 | 1.61e-01 | 0.0667 |
57140 | RNPEPL1 | LZE20T | Human | Esophagus | ESCC | 1.30e-03 | 1.34e-01 | 0.0662 |
57140 | RNPEPL1 | LZE24T | Human | Esophagus | ESCC | 4.13e-10 | 1.67e-01 | 0.0596 |
57140 | RNPEPL1 | LZE21T | Human | Esophagus | ESCC | 1.94e-02 | 2.70e-01 | 0.0655 |
57140 | RNPEPL1 | P1T-E | Human | Esophagus | ESCC | 1.42e-08 | 4.73e-01 | 0.0875 |
57140 | RNPEPL1 | P2T-E | Human | Esophagus | ESCC | 2.99e-04 | 2.84e-02 | 0.1177 |
57140 | RNPEPL1 | P4T-E | Human | Esophagus | ESCC | 1.52e-06 | 1.18e-01 | 0.1323 |
57140 | RNPEPL1 | P5T-E | Human | Esophagus | ESCC | 4.22e-10 | 9.07e-02 | 0.1327 |
57140 | RNPEPL1 | P8T-E | Human | Esophagus | ESCC | 1.55e-12 | 2.00e-01 | 0.0889 |
57140 | RNPEPL1 | P9T-E | Human | Esophagus | ESCC | 4.78e-03 | 1.63e-01 | 0.1131 |
57140 | RNPEPL1 | P10T-E | Human | Esophagus | ESCC | 5.41e-05 | 1.11e-01 | 0.116 |
57140 | RNPEPL1 | P12T-E | Human | Esophagus | ESCC | 6.44e-07 | 1.33e-01 | 0.1122 |
57140 | RNPEPL1 | P15T-E | Human | Esophagus | ESCC | 8.97e-08 | 2.63e-01 | 0.1149 |
57140 | RNPEPL1 | P16T-E | Human | Esophagus | ESCC | 1.15e-07 | 4.58e-02 | 0.1153 |
57140 | RNPEPL1 | P20T-E | Human | Esophagus | ESCC | 6.51e-10 | 1.50e-01 | 0.1124 |
57140 | RNPEPL1 | P21T-E | Human | Esophagus | ESCC | 9.49e-09 | 2.38e-01 | 0.1617 |
57140 | RNPEPL1 | P22T-E | Human | Esophagus | ESCC | 1.67e-12 | 1.21e-01 | 0.1236 |
57140 | RNPEPL1 | P23T-E | Human | Esophagus | ESCC | 1.80e-07 | 1.76e-01 | 0.108 |
57140 | RNPEPL1 | P24T-E | Human | Esophagus | ESCC | 3.31e-03 | 6.70e-02 | 0.1287 |
57140 | RNPEPL1 | P26T-E | Human | Esophagus | ESCC | 2.80e-03 | 5.17e-02 | 0.1276 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNPEPL1 | SNV | Missense_Mutation | rs759412567 | c.1126N>A | p.Glu376Lys | p.E376K | Q9HAU8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A7-A56D-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
RNPEPL1 | SNV | Missense_Mutation | c.1821N>C | p.Gln607His | p.Q607H | Q9HAU8 | protein_coding | deleterious(0.02) | probably_damaging(0.959) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RNPEPL1 | SNV | Missense_Mutation | novel | c.1230N>C | p.Gln410His | p.Q410H | Q9HAU8 | protein_coding | tolerated(1) | probably_damaging(0.967) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
RNPEPL1 | SNV | Missense_Mutation | c.1048G>A | p.Asp350Asn | p.D350N | Q9HAU8 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
RNPEPL1 | SNV | Missense_Mutation | novel | c.538N>A | p.Leu180Met | p.L180M | Q9HAU8 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RNPEPL1 | SNV | Missense_Mutation | rs369830007 | c.1208N>A | p.Arg403His | p.R403H | Q9HAU8 | protein_coding | deleterious(0.04) | probably_damaging(0.988) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RNPEPL1 | SNV | Missense_Mutation | c.1600G>C | p.Glu534Gln | p.E534Q | Q9HAU8 | protein_coding | tolerated(0.16) | possibly_damaging(0.891) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
RNPEPL1 | SNV | Missense_Mutation | c.1111N>A | p.Glu371Lys | p.E371K | Q9HAU8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
RNPEPL1 | SNV | Missense_Mutation | rs570330123 | c.2128G>A | p.Glu710Lys | p.E710K | Q9HAU8 | protein_coding | tolerated_low_confidence(0.1) | possibly_damaging(0.863) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR |
RNPEPL1 | SNV | Missense_Mutation | c.1865N>A | p.Arg622Gln | p.R622Q | Q9HAU8 | protein_coding | deleterious(0.04) | possibly_damaging(0.856) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
57140 | RNPEPL1 | ENZYME, PROTEASE, DRUGGABLE GENOME | inhibitor | CHEMBL2103847 | TOSEDOSTAT |
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