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Gene: RNPEP |
Gene summary for RNPEP |
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Gene information | Species | Human | Gene symbol | RNPEP | Gene ID | 6051 |
Gene name | arginyl aminopeptidase | |
Gene Alias | AP-B | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q9H4A4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6051 | RNPEP | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.18e-02 | 2.36e-01 | 0.0155 |
6051 | RNPEP | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.16e-20 | 9.54e-01 | -0.1808 |
6051 | RNPEP | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.39e-06 | 6.04e-01 | -0.0811 |
6051 | RNPEP | HTA11_78_2000001011 | Human | Colorectum | AD | 1.32e-05 | 4.39e-01 | -0.1088 |
6051 | RNPEP | HTA11_347_2000001011 | Human | Colorectum | AD | 3.67e-20 | 7.14e-01 | -0.1954 |
6051 | RNPEP | HTA11_411_2000001011 | Human | Colorectum | SER | 2.09e-09 | 1.43e+00 | -0.2602 |
6051 | RNPEP | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.70e-05 | 9.65e-01 | -0.2196 |
6051 | RNPEP | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.56e-08 | 6.39e-01 | -0.1207 |
6051 | RNPEP | HTA11_83_2000001011 | Human | Colorectum | SER | 2.35e-04 | 5.18e-01 | -0.1526 |
6051 | RNPEP | HTA11_696_2000001011 | Human | Colorectum | AD | 3.75e-18 | 8.33e-01 | -0.1464 |
6051 | RNPEP | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.69e-18 | 8.71e-01 | -0.059 |
6051 | RNPEP | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.75e-10 | 9.57e-01 | -0.1706 |
6051 | RNPEP | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.16e-08 | 8.17e-01 | -0.2061 |
6051 | RNPEP | HTA11_546_2000001011 | Human | Colorectum | AD | 1.41e-08 | 6.58e-01 | -0.0842 |
6051 | RNPEP | HTA11_866_3004761011 | Human | Colorectum | AD | 3.93e-06 | 4.26e-01 | 0.096 |
6051 | RNPEP | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.98e-04 | 6.34e-01 | 0.0528 |
6051 | RNPEP | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.80e-07 | 8.21e-01 | 0.0131 |
6051 | RNPEP | HTA11_6801_2000001011 | Human | Colorectum | SER | 8.80e-04 | 7.13e-01 | 0.0171 |
6051 | RNPEP | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.32e-04 | 4.42e-01 | 0.0338 |
6051 | RNPEP | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.01e-11 | 5.59e-01 | 0.0674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNPEP | SNV | Missense_Mutation | c.736N>G | p.Arg246Gly | p.R246G | Q9H4A4 | protein_coding | deleterious(0.02) | benign(0.172) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RNPEP | SNV | Missense_Mutation | novel | c.1743G>C | p.Lys581Asn | p.K581N | Q9H4A4 | protein_coding | deleterious(0.01) | possibly_damaging(0.876) | TCGA-BH-A8FZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RNPEP | SNV | Missense_Mutation | c.1160N>C | p.Gly387Ala | p.G387A | Q9H4A4 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
RNPEP | insertion | Frame_Shift_Ins | novel | c.1546_1547insGGCAC | p.Glu516GlyfsTer6 | p.E516Gfs*6 | Q9H4A4 | protein_coding | TCGA-A8-A09T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | ||
RNPEP | insertion | In_Frame_Ins | novel | c.1548_1549insTCTCTAGATGTCGTTATAACTAGGACC | p.Glu516_Leu517insSerLeuAspValValIleThrArgThr | p.E516_L517insSLDVVITRT | Q9H4A4 | protein_coding | TCGA-A8-A09T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | ||
RNPEP | insertion | Frame_Shift_Ins | novel | c.1847_1848insCTTCCTGGATAAGATCCTCCAGAAATCCCCTCTCCCTCCT | p.Glu616AspfsTer67 | p.E616Dfs*67 | Q9H4A4 | protein_coding | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
RNPEP | insertion | Frame_Shift_Ins | novel | c.493_494insA | p.Phe165TyrfsTer24 | p.F165Yfs*24 | Q9H4A4 | protein_coding | TCGA-B6-A0I5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RNPEP | insertion | Frame_Shift_Ins | novel | c.495_496insTTTACAATACAAAAATTAGCTGGACTTG | p.Val166PhefsTer32 | p.V166Ffs*32 | Q9H4A4 | protein_coding | TCGA-B6-A0I5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RNPEP | deletion | Frame_Shift_Del | novel | c.1746delC | p.Asn582LysfsTer10 | p.N582Kfs*10 | Q9H4A4 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
RNPEP | SNV | Missense_Mutation | rs747338006 | c.1219N>A | p.Asp407Asn | p.D407N | Q9H4A4 | protein_coding | tolerated(0.1) | possibly_damaging(0.545) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6051 | RNPEP | DRUGGABLE GENOME, ENZYME, PROTEASE | inhibitor | CHEMBL2103847 | TOSEDOSTAT |
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