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Gene: RNF186 |
Gene summary for RNF186 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | RNF186 | Gene ID | 54546 |
| Gene name | ring finger protein 186 | |
| Gene Alias | RNF186 | |
| Cytomap | 1p36.13 | |
| Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q9NXI6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 54546 | RNF186 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.53e-03 | 2.47e-01 | -0.1808 |
| 54546 | RNF186 | HTA11_2951_2000001011 | Human | Colorectum | AD | 9.51e-09 | 5.86e-01 | 0.0216 |
| 54546 | RNF186 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.00e-06 | 3.58e-01 | -0.0811 |
| 54546 | RNF186 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.34e-08 | 3.67e-01 | -0.1088 |
| 54546 | RNF186 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.89e-22 | 4.93e-01 | -0.1954 |
| 54546 | RNF186 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.69e-06 | 4.61e-01 | -0.2602 |
| 54546 | RNF186 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.24e-06 | 2.65e-01 | -0.1207 |
| 54546 | RNF186 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.14e-10 | 3.75e-01 | -0.1526 |
| 54546 | RNF186 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.68e-09 | 3.41e-01 | -0.1464 |
| 54546 | RNF186 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.83e-04 | 2.46e-01 | -0.1001 |
| 54546 | RNF186 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.17e-10 | 3.77e-01 | -0.059 |
| 54546 | RNF186 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.02e-05 | 2.78e-01 | -0.2061 |
| 54546 | RNF186 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.47e-12 | 5.11e-01 | -0.0842 |
| 54546 | RNF186 | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.57e-02 | 4.61e-01 | -0.00410000000000005 |
| 54546 | RNF186 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.43e-14 | 5.41e-01 | -0.0179 |
| 54546 | RNF186 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.83e-24 | 4.79e-01 | 0.096 |
| 54546 | RNF186 | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.89e-02 | 3.45e-01 | 0.0446 |
| 54546 | RNF186 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.31e-06 | 3.95e-01 | 0.0528 |
| 54546 | RNF186 | HTA11_7663_2000001011 | Human | Colorectum | SER | 3.61e-07 | 4.99e-01 | 0.0131 |
| 54546 | RNF186 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.17e-06 | 3.93e-01 | -0.0177 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
| GO:0097193 | Colorectum | AD | intrinsic apoptotic signaling pathway | 108/3918 | 288/18723 | 6.25e-11 | 6.41e-09 | 108 |
| GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
| GO:0034976 | Colorectum | AD | response to endoplasmic reticulum stress | 90/3918 | 256/18723 | 8.48e-08 | 4.28e-06 | 90 |
| GO:0070585 | Colorectum | AD | protein localization to mitochondrion | 51/3918 | 125/18723 | 3.40e-07 | 1.33e-05 | 51 |
| GO:0070059 | Colorectum | AD | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 29/3918 | 63/18723 | 7.03e-06 | 1.73e-04 | 29 |
| GO:0000209 | Colorectum | AD | protein polyubiquitination | 78/3918 | 236/18723 | 8.71e-06 | 2.06e-04 | 78 |
| GO:0051865 | Colorectum | AD | protein autoubiquitination | 28/3918 | 73/18723 | 4.87e-04 | 5.30e-03 | 28 |
| GO:0070534 | Colorectum | AD | protein K63-linked ubiquitination | 20/3918 | 56/18723 | 7.57e-03 | 4.58e-02 | 20 |
| GO:00104981 | Colorectum | SER | proteasomal protein catabolic process | 132/2897 | 490/18723 | 3.08e-11 | 5.55e-09 | 132 |
| GO:00971931 | Colorectum | SER | intrinsic apoptotic signaling pathway | 87/2897 | 288/18723 | 1.67e-10 | 2.32e-08 | 87 |
| GO:00349761 | Colorectum | SER | response to endoplasmic reticulum stress | 74/2897 | 256/18723 | 3.01e-08 | 2.05e-06 | 74 |
| GO:00431611 | Colorectum | SER | proteasome-mediated ubiquitin-dependent protein catabolic process | 105/2897 | 412/18723 | 7.48e-08 | 4.70e-06 | 105 |
| GO:00705851 | Colorectum | SER | protein localization to mitochondrion | 42/2897 | 125/18723 | 3.75e-07 | 1.98e-05 | 42 |
| GO:00700591 | Colorectum | SER | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 25/2897 | 63/18723 | 2.92e-06 | 1.18e-04 | 25 |
| GO:00002091 | Colorectum | SER | protein polyubiquitination | 58/2897 | 236/18723 | 1.69e-04 | 3.18e-03 | 58 |
| GO:00104982 | Colorectum | MSS | proteasomal protein catabolic process | 157/3467 | 490/18723 | 2.39e-13 | 5.25e-11 | 157 |
| GO:00971932 | Colorectum | MSS | intrinsic apoptotic signaling pathway | 102/3467 | 288/18723 | 6.06e-12 | 9.82e-10 | 102 |
| GO:00431612 | Colorectum | MSS | proteasome-mediated ubiquitin-dependent protein catabolic process | 127/3467 | 412/18723 | 7.70e-10 | 6.32e-08 | 127 |
| GO:00349762 | Colorectum | MSS | response to endoplasmic reticulum stress | 81/3467 | 256/18723 | 2.65e-07 | 1.10e-05 | 81 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| RNF186 | SNV | Missense_Mutation | novel | c.307G>A | p.Glu103Lys | p.E103K | Q9NXI6 | protein_coding | deleterious(0.03) | benign(0.067) | TCGA-C8-A3M7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
| RNF186 | SNV | Missense_Mutation | rs199500273 | c.271N>A | p.Val91Ile | p.V91I | Q9NXI6 | protein_coding | tolerated(0.05) | benign(0.01) | TCGA-C5-A1BF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
| RNF186 | SNV | Missense_Mutation | c.83N>T | p.Gly28Val | p.G28V | Q9NXI6 | protein_coding | tolerated(0.13) | benign(0.009) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| RNF186 | SNV | Missense_Mutation | novel | c.484N>A | p.Leu162Met | p.L162M | Q9NXI6 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| RNF186 | SNV | Missense_Mutation | c.488N>T | p.Ala163Val | p.A163V | Q9NXI6 | protein_coding | tolerated(1) | benign(0.001) | TCGA-B5-A11N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| RNF186 | SNV | Missense_Mutation | novel | c.511N>T | p.Pro171Ser | p.P171S | Q9NXI6 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| RNF186 | SNV | Missense_Mutation | c.74N>T | p.Ala25Val | p.A25V | Q9NXI6 | protein_coding | tolerated(0.13) | benign(0.005) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| RNF186 | SNV | Missense_Mutation | novel | c.565N>A | p.Ala189Thr | p.A189T | Q9NXI6 | protein_coding | deleterious(0.03) | benign(0.22) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
| RNF186 | SNV | Missense_Mutation | novel | c.445N>T | p.His149Tyr | p.H149Y | Q9NXI6 | protein_coding | deleterious(0.03) | benign(0.131) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
| RNF186 | SNV | Missense_Mutation | novel | c.359N>A | p.Pro120His | p.P120H | Q9NXI6 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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