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Gene: RNF150 |
Gene summary for RNF150 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | RNF150 | Gene ID | 57484 |
| Gene name | ring finger protein 150 | |
| Gene Alias | RNF150 | |
| Cytomap | 4q31.21 | |
| Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9ULK6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 57484 | RNF150 | AEH-subject2 | Human | Endometrium | AEH | 5.80e-05 | 2.61e-01 | -0.2525 |
| 57484 | RNF150 | AEH-subject3 | Human | Endometrium | AEH | 4.44e-08 | 3.21e-01 | -0.2576 |
| 57484 | RNF150 | AEH-subject4 | Human | Endometrium | AEH | 8.72e-09 | 4.50e-01 | -0.2657 |
| 57484 | RNF150 | EEC-subject1 | Human | Endometrium | EEC | 5.17e-08 | 3.30e-01 | -0.2682 |
| 57484 | RNF150 | EEC-subject2 | Human | Endometrium | EEC | 2.68e-05 | 2.88e-01 | -0.2607 |
| 57484 | RNF150 | EEC-subject3 | Human | Endometrium | EEC | 8.50e-09 | -1.02e-01 | -0.2525 |
| 57484 | RNF150 | EEC-subject4 | Human | Endometrium | EEC | 2.15e-02 | 1.49e-01 | -0.2571 |
| 57484 | RNF150 | EEC-subject5 | Human | Endometrium | EEC | 2.91e-06 | 3.31e-01 | -0.249 |
| 57484 | RNF150 | GSM5276934 | Human | Endometrium | EEC | 4.23e-05 | -1.42e-01 | -0.0913 |
| 57484 | RNF150 | GSM5276935 | Human | Endometrium | EEC | 2.54e-05 | -1.42e-01 | -0.123 |
| 57484 | RNF150 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 3.65e-07 | 1.00e-01 | -0.1869 |
| 57484 | RNF150 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.28e-06 | -5.37e-03 | -0.1875 |
| 57484 | RNF150 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.89e-07 | 3.93e-02 | -0.1883 |
| 57484 | RNF150 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.74e-04 | 8.70e-02 | -0.1934 |
| 57484 | RNF150 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 7.50e-16 | 2.36e-01 | -0.1917 |
| 57484 | RNF150 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.80e-13 | 2.22e-01 | -0.1916 |
| 57484 | RNF150 | HTA12-15-2 | Human | Pancreas | PDAC | 2.40e-02 | 2.81e-01 | 0.2315 |
| 57484 | RNF150 | HTA12-23-1 | Human | Pancreas | PDAC | 1.02e-03 | 5.62e-01 | 0.3405 |
| 57484 | RNF150 | HTA12-26-1 | Human | Pancreas | PDAC | 1.13e-11 | 6.98e-01 | 0.3728 |
| 57484 | RNF150 | HTA12-29-1 | Human | Pancreas | PDAC | 1.70e-20 | 5.41e-01 | 0.3722 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| RNF150 | SNV | Missense_Mutation | novel | c.103N>A | p.Glu35Lys | p.E35K | Q9ULK6 | protein_coding | tolerated(0.12) | benign(0.173) | TCGA-C8-A3M7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
| RNF150 | SNV | Missense_Mutation | rs368156046 | c.11C>T | p.Ser4Phe | p.S4F | Q9ULK6 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.99) | TCGA-FU-A23K-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
| RNF150 | SNV | Missense_Mutation | rs267600025 | c.623C>T | p.Ser208Leu | p.S208L | Q9ULK6 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| RNF150 | SNV | Missense_Mutation | novel | c.296N>A | p.Arg99His | p.R99H | Q9ULK6 | protein_coding | tolerated(0.23) | benign(0.17) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| RNF150 | SNV | Missense_Mutation | novel | c.481N>A | p.Ala161Thr | p.A161T | Q9ULK6 | protein_coding | tolerated(0.23) | benign(0.046) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| RNF150 | SNV | Missense_Mutation | rs267600025 | c.623N>T | p.Ser208Leu | p.S208L | Q9ULK6 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| RNF150 | SNV | Missense_Mutation | novel | c.418N>A | p.Ala140Thr | p.A140T | Q9ULK6 | protein_coding | deleterious(0.01) | probably_damaging(0.981) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| RNF150 | SNV | Missense_Mutation | c.764N>T | p.Ala255Val | p.A255V | Q9ULK6 | protein_coding | tolerated(0.14) | possibly_damaging(0.685) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| RNF150 | SNV | Missense_Mutation | c.512N>A | p.Ile171Asn | p.I171N | Q9ULK6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| RNF150 | SNV | Missense_Mutation | novel | c.5N>T | p.Ala2Val | p.A2V | Q9ULK6 | protein_coding | tolerated_low_confidence(0.15) | benign(0) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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