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Gene: RNF145 |
Gene summary for RNF145 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | RNF145 | Gene ID | 153830 |
| Gene name | ring finger protein 145 | |
| Gene Alias | RNF145 | |
| Cytomap | 5q33.3 | |
| Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8NDT8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 153830 | RNF145 | CA_HPV_1 | Human | Cervix | CC | 5.37e-04 | 7.98e-02 | 0.0264 |
| 153830 | RNF145 | CCI_2 | Human | Cervix | CC | 1.04e-10 | 1.01e+00 | 0.5249 |
| 153830 | RNF145 | CCI_3 | Human | Cervix | CC | 2.11e-03 | 5.76e-01 | 0.516 |
| 153830 | RNF145 | Tumor | Human | Cervix | CC | 1.02e-02 | -2.71e-01 | 0.1241 |
| 153830 | RNF145 | LZE4T | Human | Esophagus | ESCC | 1.65e-09 | -2.25e-01 | 0.0811 |
| 153830 | RNF145 | LZE5T | Human | Esophagus | ESCC | 9.40e-06 | -7.82e-02 | 0.0514 |
| 153830 | RNF145 | LZE7T | Human | Esophagus | ESCC | 1.82e-08 | -1.83e-01 | 0.0667 |
| 153830 | RNF145 | LZE8T | Human | Esophagus | ESCC | 1.03e-05 | -2.45e-01 | 0.067 |
| 153830 | RNF145 | LZE20T | Human | Esophagus | ESCC | 4.14e-10 | -3.98e-02 | 0.0662 |
| 153830 | RNF145 | LZE22D1 | Human | Esophagus | HGIN | 7.27e-03 | -9.04e-02 | 0.0595 |
| 153830 | RNF145 | LZE24T | Human | Esophagus | ESCC | 8.66e-13 | 5.68e-01 | 0.0596 |
| 153830 | RNF145 | P1T-E | Human | Esophagus | ESCC | 7.29e-04 | 7.17e-01 | 0.0875 |
| 153830 | RNF145 | P2T-E | Human | Esophagus | ESCC | 6.61e-14 | 2.94e-01 | 0.1177 |
| 153830 | RNF145 | P4T-E | Human | Esophagus | ESCC | 2.75e-24 | 5.77e-01 | 0.1323 |
| 153830 | RNF145 | P5T-E | Human | Esophagus | ESCC | 9.67e-22 | 4.27e-01 | 0.1327 |
| 153830 | RNF145 | P8T-E | Human | Esophagus | ESCC | 6.30e-19 | 4.17e-01 | 0.0889 |
| 153830 | RNF145 | P9T-E | Human | Esophagus | ESCC | 5.58e-24 | 7.31e-01 | 0.1131 |
| 153830 | RNF145 | P10T-E | Human | Esophagus | ESCC | 2.93e-15 | 4.19e-01 | 0.116 |
| 153830 | RNF145 | P11T-E | Human | Esophagus | ESCC | 7.22e-06 | 4.80e-01 | 0.1426 |
| 153830 | RNF145 | P12T-E | Human | Esophagus | ESCC | 1.04e-15 | 4.30e-01 | 0.1122 |
| Page: 1 2 3 4 5 6 7 8 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| RNF145 | SNV | Missense_Mutation | novel | c.116N>T | p.Ala39Val | p.A39V | Q96MT1 | protein_coding | tolerated(0.13) | possibly_damaging(0.862) | TCGA-A2-A3Y0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
| RNF145 | SNV | Missense_Mutation | rs150853320 | c.998N>A | p.Arg333Gln | p.R333Q | Q96MT1 | protein_coding | tolerated(0.53) | benign(0.076) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| RNF145 | SNV | Missense_Mutation | c.722N>C | p.Val241Ala | p.V241A | Q96MT1 | protein_coding | tolerated(0.29) | benign(0.159) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| RNF145 | SNV | Missense_Mutation | novel | c.146N>T | p.Ser49Ile | p.S49I | Q96MT1 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| RNF145 | SNV | Missense_Mutation | c.1789G>C | p.Val597Leu | p.V597L | Q96MT1 | protein_coding | deleterious(0.02) | probably_damaging(0.939) | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
| RNF145 | SNV | Missense_Mutation | c.1517N>C | p.Glu506Ala | p.E506A | Q96MT1 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-C8-A26X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
| RNF145 | insertion | Nonsense_Mutation | novel | c.274_274+1insTAATAACCCTCTTTTCCAGTATAAGTATTTGGCTCTTAATATGCATTATGTAG | p.Gly92ValfsTer18 | p.G92Vfs*18 | Q96MT1 | protein_coding | TCGA-C8-A1HN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| RNF145 | SNV | Missense_Mutation | rs377687714 | c.1703C>T | p.Ala568Val | p.A568V | Q96MT1 | protein_coding | deleterious(0.01) | possibly_damaging(0.657) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| RNF145 | SNV | Missense_Mutation | novel | c.1832N>A | p.Ser611Tyr | p.S611Y | Q96MT1 | protein_coding | deleterious(0.03) | benign(0.191) | TCGA-EA-A43B-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| RNF145 | SNV | Missense_Mutation | c.936N>G | p.Phe312Leu | p.F312L | Q96MT1 | protein_coding | deleterious(0.01) | possibly_damaging(0.813) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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