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Gene: RNF141 |
Gene summary for RNF141 |
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Gene information | Species | Human | Gene symbol | RNF141 | Gene ID | 50862 |
Gene name | ring finger protein 141 | |
Gene Alias | RFP141 | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8WVD5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
50862 | RNF141 | LZE3D | Human | Esophagus | HGIN | 9.68e-03 | 5.11e-01 | 0.0668 |
50862 | RNF141 | LZE4T | Human | Esophagus | ESCC | 9.11e-18 | 3.71e-01 | 0.0811 |
50862 | RNF141 | LZE5T | Human | Esophagus | ESCC | 8.54e-10 | 3.23e-01 | 0.0514 |
50862 | RNF141 | LZE7T | Human | Esophagus | ESCC | 1.67e-02 | 8.17e-02 | 0.0667 |
50862 | RNF141 | LZE8T | Human | Esophagus | ESCC | 5.21e-10 | 2.94e-01 | 0.067 |
50862 | RNF141 | LZE20T | Human | Esophagus | ESCC | 6.30e-10 | 4.26e-01 | 0.0662 |
50862 | RNF141 | LZE24T | Human | Esophagus | ESCC | 6.51e-24 | 7.39e-01 | 0.0596 |
50862 | RNF141 | LZE6T | Human | Esophagus | ESCC | 4.09e-06 | 3.23e-01 | 0.0845 |
50862 | RNF141 | P1T-E | Human | Esophagus | ESCC | 6.02e-07 | 3.12e-01 | 0.0875 |
50862 | RNF141 | P2T-E | Human | Esophagus | ESCC | 5.67e-34 | 5.76e-01 | 0.1177 |
50862 | RNF141 | P4T-E | Human | Esophagus | ESCC | 4.54e-18 | 3.51e-01 | 0.1323 |
50862 | RNF141 | P5T-E | Human | Esophagus | ESCC | 1.59e-21 | 3.15e-01 | 0.1327 |
50862 | RNF141 | P8T-E | Human | Esophagus | ESCC | 1.28e-15 | 1.60e-01 | 0.0889 |
50862 | RNF141 | P9T-E | Human | Esophagus | ESCC | 4.14e-21 | 4.69e-01 | 0.1131 |
50862 | RNF141 | P10T-E | Human | Esophagus | ESCC | 7.68e-26 | 3.13e-01 | 0.116 |
50862 | RNF141 | P11T-E | Human | Esophagus | ESCC | 9.20e-16 | 6.88e-01 | 0.1426 |
50862 | RNF141 | P12T-E | Human | Esophagus | ESCC | 4.54e-14 | 1.30e-01 | 0.1122 |
50862 | RNF141 | P15T-E | Human | Esophagus | ESCC | 9.69e-31 | 5.58e-01 | 0.1149 |
50862 | RNF141 | P16T-E | Human | Esophagus | ESCC | 9.37e-23 | 4.03e-01 | 0.1153 |
50862 | RNF141 | P17T-E | Human | Esophagus | ESCC | 6.91e-13 | 7.95e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00518658 | Esophagus | ESCC | protein autoubiquitination | 47/8552 | 73/18723 | 9.72e-04 | 4.93e-03 | 47 |
GO:00518654 | Liver | HCC | protein autoubiquitination | 42/7958 | 73/18723 | 6.78e-03 | 2.73e-02 | 42 |
GO:00518657 | Oral cavity | OSCC | protein autoubiquitination | 40/7305 | 73/18723 | 4.45e-03 | 1.79e-02 | 40 |
GO:005186512 | Oral cavity | LP | protein autoubiquitination | 29/4623 | 73/18723 | 3.20e-03 | 2.18e-02 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNF141 | SNV | Missense_Mutation | novel | c.99A>T | p.Leu33Phe | p.L33F | Q8WVD5 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
RNF141 | SNV | Missense_Mutation | novel | c.296N>C | p.Asn99Thr | p.N99T | Q8WVD5 | protein_coding | deleterious(0) | benign(0.159) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RNF141 | SNV | Missense_Mutation | rs752292152 | c.575N>A | p.Arg192His | p.R192H | Q8WVD5 | protein_coding | tolerated(0.05) | possibly_damaging(0.534) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RNF141 | insertion | Frame_Shift_Ins | novel | c.57_58insA | p.Val20SerfsTer17 | p.V20Sfs*17 | Q8WVD5 | protein_coding | TCGA-5M-AATE-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
RNF141 | SNV | Missense_Mutation | novel | c.651N>G | p.Ile217Met | p.I217M | Q8WVD5 | protein_coding | deleterious(0.01) | probably_damaging(0.965) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
RNF141 | SNV | Missense_Mutation | novel | c.200N>A | p.Gly67Glu | p.G67E | Q8WVD5 | protein_coding | deleterious(0.01) | benign(0.234) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RNF141 | SNV | Missense_Mutation | novel | c.4G>A | p.Gly2Arg | p.G2R | Q8WVD5 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RNF141 | SNV | Missense_Mutation | novel | c.181C>A | p.Leu61Ile | p.L61I | Q8WVD5 | protein_coding | tolerated(0.16) | benign(0.236) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RNF141 | SNV | Missense_Mutation | novel | c.153N>T | p.Lys51Asn | p.K51N | Q8WVD5 | protein_coding | tolerated(0.23) | benign(0.261) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RNF141 | SNV | Missense_Mutation | c.361N>C | p.Ser121Arg | p.S121R | Q8WVD5 | protein_coding | tolerated(0.54) | benign(0.014) | TCGA-BG-A0VT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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