Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: RNASEH1-AS1

Gene summary for RNASEH1-AS1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

RNASEH1-AS1

Gene ID

100506054

Gene nameRNASEH1 divergent transcript
Gene AliasRNASEH1-AS1
Cytomap2p25.3
Gene TypencRNA
GO ID

NA

UniProtAcc

NA


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
100506054RNASEH1-AS1LZE24THumanEsophagusESCC7.38e-088.74e-020.0596
100506054RNASEH1-AS1LZE6THumanEsophagusESCC1.92e-031.46e-010.0845
100506054RNASEH1-AS1P2T-EHumanEsophagusESCC5.43e-202.40e-010.1177
100506054RNASEH1-AS1P4T-EHumanEsophagusESCC9.85e-071.44e-010.1323
100506054RNASEH1-AS1P5T-EHumanEsophagusESCC2.65e-056.06e-020.1327
100506054RNASEH1-AS1P8T-EHumanEsophagusESCC3.32e-061.00e-010.0889
100506054RNASEH1-AS1P9T-EHumanEsophagusESCC5.18e-036.08e-020.1131
100506054RNASEH1-AS1P10T-EHumanEsophagusESCC4.24e-045.65e-020.116
100506054RNASEH1-AS1P12T-EHumanEsophagusESCC1.28e-141.64e-010.1122
100506054RNASEH1-AS1P15T-EHumanEsophagusESCC1.77e-044.26e-020.1149
100506054RNASEH1-AS1P16T-EHumanEsophagusESCC1.84e-081.32e-010.1153
100506054RNASEH1-AS1P19T-EHumanEsophagusESCC1.57e-074.37e-010.1662
100506054RNASEH1-AS1P21T-EHumanEsophagusESCC3.16e-193.04e-010.1617
100506054RNASEH1-AS1P22T-EHumanEsophagusESCC7.45e-162.11e-010.1236
100506054RNASEH1-AS1P23T-EHumanEsophagusESCC2.83e-071.30e-010.108
100506054RNASEH1-AS1P24T-EHumanEsophagusESCC4.58e-181.66e-010.1287
100506054RNASEH1-AS1P26T-EHumanEsophagusESCC1.49e-243.55e-010.1276
100506054RNASEH1-AS1P28T-EHumanEsophagusESCC4.14e-131.75e-010.1149
100506054RNASEH1-AS1P30T-EHumanEsophagusESCC1.29e-051.21e-010.137
100506054RNASEH1-AS1P31T-EHumanEsophagusESCC1.56e-097.28e-020.1251
Page: 1 2 3 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
Page: 1 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
Page: 1 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1