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Gene: RNA28S5 |
Gene summary for RNA28S5 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | RNA28S5 | Gene ID | 110255168 |
| Gene name | RNA, 28S ribosomal 5 | |
| Gene Alias | RN28S1 | |
| Cytomap | 22p12 | |
| Gene Type | rRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 110255168 | RNA28S5 | GSM5353215_PA_AUG_PB_1B_S2 | Human | Prostate | Tumor | 1.17e-38 | 2.41e+00 | 0.1557 |
| 110255168 | RNA28S5 | GSM5353216_PA_PB1A_Pool_1_3_S50_L002 | Human | Prostate | Tumor | 6.44e-33 | 2.12e+00 | 0.159 |
| 110255168 | RNA28S5 | GSM5353217_PA_PB1A_Pool_2_S107_L004 | Human | Prostate | Tumor | 2.82e-22 | 2.14e+00 | 0.156 |
| 110255168 | RNA28S5 | GSM5353218_PA_PB1B_Pool_1_2_S74_L003 | Human | Prostate | Tumor | 6.89e-31 | 2.35e+00 | 0.1479 |
| 110255168 | RNA28S5 | GSM5353220_PA_PB1B_Pool_3_S51_L002 | Human | Prostate | Tumor | 6.44e-33 | 2.27e+00 | 0.1531 |
| 110255168 | RNA28S5 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 5.01e-81 | 2.13e+00 | 0.1633 |
| 110255168 | RNA28S5 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 1.88e-99 | 2.11e+00 | 0.1608 |
| 110255168 | RNA28S5 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 6.11e-64 | 2.10e+00 | 0.1604 |
| 110255168 | RNA28S5 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 3.54e-76 | 2.20e+00 | 0.1621 |
| 110255168 | RNA28S5 | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 5.57e-48 | 2.22e+00 | 0.1619 |
| 110255168 | RNA28S5 | GSM5353226_PA_PR5196-2_Pool_1_2_3_S54_L002 | Human | Prostate | Tumor | 3.72e-36 | 2.24e+00 | 0.159 |
| 110255168 | RNA28S5 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 3.15e-81 | 2.26e+00 | 0.1602 |
| 110255168 | RNA28S5 | GSM5353228_PA_PR5199-640K_Pool_1_3_S108_L004 | Human | Prostate | Tumor | 1.40e-18 | 1.92e+00 | 0.1537 |
| 110255168 | RNA28S5 | GSM5353232_PA_PR5249_T1_S3_L001 | Human | Prostate | Tumor | 3.25e-17 | 1.85e+00 | 0.1439 |
| 110255168 | RNA28S5 | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 1.05e-50 | 2.30e+00 | 0.1608 |
| 110255168 | RNA28S5 | GSM5353237_PA_PR5251_T2_S8_L001 | Human | Prostate | Tumor | 3.72e-36 | 2.26e+00 | 0.1622 |
| 110255168 | RNA28S5 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 1.08e-101 | 2.14e+00 | 0.1575 |
| 110255168 | RNA28S5 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 1.24e-70 | 1.81e+00 | 0.1545 |
| 110255168 | RNA28S5 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 4.42e-88 | 2.21e+00 | 0.1569 |
| 110255168 | RNA28S5 | GSM5353247_PA_PR5269_3_S27_L002 | Human | Prostate | Tumor | 5.41e-18 | 2.04e+00 | 0.1532 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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