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Gene: RN7SK |
Gene summary for RN7SK |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | RN7SK | Gene ID | 125050 |
| Gene name | RNA component of 7SK nuclear ribonucleoprotein | |
| Gene Alias | 7SK | |
| Cytomap | 6p12.2 | |
| Gene Type | snRNA | GO ID | GO:0006139 | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 125050 | RN7SK | Adj_PTCwithHT_8 | Human | Thyroid | HT | 4.06e-03 | -4.95e-01 | 0.0267 |
| 125050 | RN7SK | PTCwithHT_6 | Human | Thyroid | HT | 9.24e-08 | -5.18e-01 | 0.02 |
| 125050 | RN7SK | male-WTA | Human | Thyroid | PTC | 5.71e-10 | -5.64e-01 | 0.1037 |
| 125050 | RN7SK | female-WTA | Human | Thyroid | PTC | 8.06e-03 | -5.64e-01 | 0.0726 |
| 125050 | RN7SK | nodule-WTA | Human | Thyroid | goiters | 2.02e-08 | -5.64e-01 | 0.0534 |
| 125050 | RN7SK | PTC01 | Human | Thyroid | PTC | 5.88e-09 | -5.64e-01 | 0.1899 |
| 125050 | RN7SK | PTC04 | Human | Thyroid | PTC | 5.71e-10 | -5.64e-01 | 0.1927 |
| 125050 | RN7SK | PTC06 | Human | Thyroid | PTC | 4.16e-06 | -5.64e-01 | 0.2057 |
| 125050 | RN7SK | PTC07 | Human | Thyroid | PTC | 2.61e-10 | -5.64e-01 | 0.2044 |
| 125050 | RN7SK | ATC09 | Human | Thyroid | ATC | 4.82e-02 | -5.64e-01 | 0.2871 |
| 125050 | RN7SK | ATC12 | Human | Thyroid | ATC | 2.71e-09 | -5.64e-01 | 0.34 |
| 125050 | RN7SK | ATC13 | Human | Thyroid | ATC | 2.61e-10 | -5.64e-01 | 0.34 |
| 125050 | RN7SK | ATC4 | Human | Thyroid | ATC | 1.92e-09 | -5.64e-01 | 0.34 |
| 125050 | RN7SK | ATC5 | Human | Thyroid | ATC | 2.71e-09 | -5.64e-01 | 0.34 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00063689 | Thyroid | HT | transcription elongation from RNA polymerase II promoter | 12/1272 | 69/18723 | 2.19e-03 | 1.88e-02 | 12 |
| GO:000635410 | Thyroid | HT | DNA-templated transcription, elongation | 14/1272 | 91/18723 | 3.23e-03 | 2.55e-02 | 14 |
| GO:000635416 | Thyroid | PTC | DNA-templated transcription, elongation | 62/5968 | 91/18723 | 1.30e-12 | 5.91e-11 | 62 |
| GO:000636816 | Thyroid | PTC | transcription elongation from RNA polymerase II promoter | 48/5968 | 69/18723 | 1.43e-10 | 4.81e-09 | 48 |
| GO:00327846 | Thyroid | PTC | regulation of DNA-templated transcription, elongation | 38/5968 | 53/18723 | 3.07e-09 | 8.43e-08 | 38 |
| GO:00342437 | Thyroid | PTC | regulation of transcription elongation from RNA polymerase II promoter | 24/5968 | 32/18723 | 6.76e-07 | 1.07e-05 | 24 |
| GO:00342445 | Thyroid | PTC | negative regulation of transcription elongation from RNA polymerase II promoter | 13/5968 | 16/18723 | 6.82e-05 | 5.97e-04 | 13 |
| GO:00327855 | Thyroid | PTC | negative regulation of DNA-templated transcription, elongation | 14/5968 | 18/18723 | 8.31e-05 | 7.01e-04 | 14 |
| GO:000635421 | Thyroid | ATC | DNA-templated transcription, elongation | 63/6293 | 91/18723 | 3.89e-12 | 1.55e-10 | 63 |
| GO:000636822 | Thyroid | ATC | transcription elongation from RNA polymerase II promoter | 49/6293 | 69/18723 | 2.32e-10 | 6.72e-09 | 49 |
| GO:003278414 | Thyroid | ATC | regulation of DNA-templated transcription, elongation | 39/6293 | 53/18723 | 3.04e-09 | 7.10e-08 | 39 |
| GO:003424314 | Thyroid | ATC | regulation of transcription elongation from RNA polymerase II promoter | 25/6293 | 32/18723 | 3.13e-07 | 4.68e-06 | 25 |
| GO:003424412 | Thyroid | ATC | negative regulation of transcription elongation from RNA polymerase II promoter | 14/6293 | 16/18723 | 1.32e-05 | 1.26e-04 | 14 |
| GO:003278512 | Thyroid | ATC | negative regulation of DNA-templated transcription, elongation | 15/6293 | 18/18723 | 2.06e-05 | 1.85e-04 | 15 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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