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Gene: RHPN1 |
Gene summary for RHPN1 |
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Gene information | Species | Human | Gene symbol | RHPN1 | Gene ID | 114822 |
Gene name | rhophilin Rho GTPase binding protein 1 | |
Gene Alias | ODF5 | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q8TCX5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114822 | RHPN1 | HCC1_Meng | Human | Liver | HCC | 9.45e-09 | 3.63e-02 | 0.0246 |
114822 | RHPN1 | HCC2_Meng | Human | Liver | HCC | 4.23e-17 | 1.71e-01 | 0.0107 |
114822 | RHPN1 | S014 | Human | Liver | HCC | 1.92e-08 | 3.26e-01 | 0.2254 |
114822 | RHPN1 | S015 | Human | Liver | HCC | 5.21e-17 | 5.92e-01 | 0.2375 |
114822 | RHPN1 | S016 | Human | Liver | HCC | 8.16e-08 | 2.73e-01 | 0.2243 |
114822 | RHPN1 | S027 | Human | Liver | HCC | 9.66e-20 | 8.41e-01 | 0.2446 |
114822 | RHPN1 | S028 | Human | Liver | HCC | 1.69e-33 | 9.02e-01 | 0.2503 |
114822 | RHPN1 | S029 | Human | Liver | HCC | 2.30e-29 | 8.49e-01 | 0.2581 |
114822 | RHPN1 | male-WTA | Human | Thyroid | PTC | 1.22e-05 | 9.03e-02 | 0.1037 |
114822 | RHPN1 | PTC01 | Human | Thyroid | PTC | 1.80e-19 | 3.01e-01 | 0.1899 |
114822 | RHPN1 | PTC03 | Human | Thyroid | PTC | 2.61e-06 | 3.40e-01 | 0.1784 |
114822 | RHPN1 | PTC04 | Human | Thyroid | PTC | 1.71e-15 | 2.80e-01 | 0.1927 |
114822 | RHPN1 | PTC05 | Human | Thyroid | PTC | 1.32e-28 | 8.59e-01 | 0.2065 |
114822 | RHPN1 | PTC06 | Human | Thyroid | PTC | 6.41e-31 | 6.91e-01 | 0.2057 |
114822 | RHPN1 | PTC07 | Human | Thyroid | PTC | 1.41e-32 | 4.92e-01 | 0.2044 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RHPN1 | SNV | Missense_Mutation | rs767143007 | c.994G>A | p.Val332Ile | p.V332I | Q8TCX5 | protein_coding | tolerated(0.12) | benign(0.043) | TCGA-A7-A4SD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
RHPN1 | SNV | Missense_Mutation | novel | c.1192N>A | p.Glu398Lys | p.E398K | Q8TCX5 | protein_coding | tolerated(0.65) | benign(0.112) | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RHPN1 | SNV | Missense_Mutation | rs150183295 | c.307G>A | p.Glu103Lys | p.E103K | Q8TCX5 | protein_coding | deleterious(0.01) | possibly_damaging(0.618) | TCGA-C5-A2LY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
RHPN1 | SNV | Missense_Mutation | rs553239044 | c.211N>A | p.Ala71Thr | p.A71T | Q8TCX5 | protein_coding | tolerated(0.21) | probably_damaging(0.967) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RHPN1 | SNV | Missense_Mutation | c.406N>A | p.Glu136Lys | p.E136K | Q8TCX5 | protein_coding | deleterious(0.02) | probably_damaging(0.967) | TCGA-EK-A2PM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
RHPN1 | deletion | In_Frame_Del | novel | c.140_154delNNNNNNNNNNNNNNN | p.Glu47_Thr52delinsAla | p.E47_T52delinsA | Q8TCX5 | protein_coding | TCGA-VS-A9UZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
RHPN1 | SNV | Missense_Mutation | rs776053563 | c.1264N>T | p.Arg422Trp | p.R422W | Q8TCX5 | protein_coding | deleterious(0.02) | probably_damaging(0.989) | TCGA-A6-4105-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
RHPN1 | SNV | Missense_Mutation | c.1653N>T | p.Glu551Asp | p.E551D | Q8TCX5 | protein_coding | deleterious(0.02) | probably_damaging(0.963) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RHPN1 | SNV | Missense_Mutation | c.1327A>G | p.Thr443Ala | p.T443A | Q8TCX5 | protein_coding | tolerated(1) | benign(0.003) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RHPN1 | SNV | Missense_Mutation | rs773302154 | c.1916N>A | p.Arg639Gln | p.R639Q | Q8TCX5 | protein_coding | deleterious(0.04) | possibly_damaging(0.482) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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