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Gene: RGS5 |
Gene summary for RGS5 |
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Gene information | Species | Human | Gene symbol | RGS5 | Gene ID | 8490 |
Gene name | regulator of G protein signaling 5 | |
Gene Alias | MST092 | |
Cytomap | 1q23.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | O15539 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8490 | RGS5 | P23T-E | Human | Esophagus | ESCC | 3.93e-02 | 1.85e+00 | 0.108 |
8490 | RGS5 | P94T-E | Human | Esophagus | ESCC | 1.64e-02 | 1.72e+00 | 0.0879 |
8490 | RGS5 | P104T-E | Human | Esophagus | ESCC | 4.20e-05 | 1.28e+00 | 0.0931 |
8490 | RGS5 | HCC1_Meng | Human | Liver | HCC | 2.12e-04 | -1.42e-01 | 0.0246 |
8490 | RGS5 | HCC5 | Human | Liver | HCC | 3.69e-09 | 5.00e-02 | 0.4932 |
8490 | RGS5 | Pt13.a | Human | Liver | HCC | 8.83e-19 | 7.26e-01 | 0.021 |
8490 | RGS5 | Pt13.b | Human | Liver | HCC | 7.93e-34 | 1.18e+00 | 0.0251 |
8490 | RGS5 | Pt13.c | Human | Liver | HCC | 2.01e-12 | 7.21e-01 | 0.0076 |
8490 | RGS5 | Pt14.b | Human | Liver | HCC | 7.51e-05 | 8.49e-01 | 0.018 |
8490 | RGS5 | Pt14.d | Human | Liver | HCC | 1.26e-19 | 6.62e-01 | 0.0143 |
8490 | RGS5 | C43 | Human | Oral cavity | OSCC | 1.43e-06 | -3.78e-01 | 0.1704 |
8490 | RGS5 | C46 | Human | Oral cavity | OSCC | 9.00e-05 | -3.77e-01 | 0.1673 |
8490 | RGS5 | C08 | Human | Oral cavity | OSCC | 8.31e-06 | -3.76e-01 | 0.1919 |
8490 | RGS5 | C09 | Human | Oral cavity | OSCC | 1.13e-02 | -3.73e-01 | 0.1431 |
8490 | RGS5 | NEOLP-2 | Human | Oral cavity | NEOLP | 1.13e-05 | 5.96e-01 | -0.0196 |
8490 | RGS5 | NEOLP-3 | Human | Oral cavity | NEOLP | 5.04e-04 | 5.73e-01 | -0.0191 |
8490 | RGS5 | SYSMH1 | Human | Oral cavity | OSCC | 1.90e-10 | -3.85e-01 | 0.1127 |
8490 | RGS5 | SYSMH2 | Human | Oral cavity | OSCC | 6.00e-07 | -3.77e-01 | 0.2326 |
8490 | RGS5 | SYSMH3 | Human | Oral cavity | OSCC | 9.03e-10 | -3.86e-01 | 0.2442 |
8490 | RGS5 | SYSMH4 | Human | Oral cavity | OSCC | 2.91e-07 | -3.85e-01 | 0.1226 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RGS5 | SNV | Missense_Mutation | c.509N>A | p.Ser170Tyr | p.S170Y | O15539 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A09Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | |
RGS5 | SNV | Missense_Mutation | c.505N>A | p.Asp169Asn | p.D169N | O15539 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AR-A0U3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
RGS5 | insertion | In_Frame_Ins | novel | c.269_270insTATCCAACTTCAGACATTCTTAGATGTGGGACTTTGGGC | p.Asn90_Leu91insIleGlnLeuGlnThrPheLeuAspValGlyLeuTrpAla | p.N90_L91insIQLQTFLDVGLWA | O15539 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
RGS5 | SNV | Missense_Mutation | c.482G>C | p.Arg161Thr | p.R161T | O15539 | protein_coding | deleterious(0.02) | possibly_damaging(0.814) | TCGA-Q1-A73P-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
RGS5 | SNV | Missense_Mutation | novel | c.160N>C | p.Ser54Pro | p.S54P | O15539 | protein_coding | tolerated(0.06) | benign(0.053) | TCGA-AZ-5407-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RGS5 | SNV | Missense_Mutation | rs758639664 | c.518N>A | p.Arg173His | p.R173H | O15539 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RGS5 | SNV | Missense_Mutation | rs767246365 | c.184C>T | p.Arg62Cys | p.R62C | O15539 | protein_coding | deleterious(0.03) | possibly_damaging(0.79) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RGS5 | deletion | Frame_Shift_Del | c.269delN | p.Asn90ThrfsTer44 | p.N90Tfs*44 | O15539 | protein_coding | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
RGS5 | insertion | Frame_Shift_Ins | novel | c.88_89insTA | p.Pro30LeufsTer54 | p.P30Lfs*54 | O15539 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RGS5 | insertion | Frame_Shift_Ins | novel | c.87_88insTT | p.Pro30PhefsTer54 | p.P30Ffs*54 | O15539 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8490 | RGS5 | NA | irinotecan | IRINOTECAN | 25069475 | |
8490 | RGS5 | NA | bevacizumab | BEVACIZUMAB | 25069475 | |
8490 | RGS5 | NA | fluorouracil | FLUOROURACIL | 25069475 | |
8490 | RGS5 | NA | leucovorin | LEUCOVORIN | 25069475 |
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