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Gene: RGS12 |
Gene summary for RGS12 |
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Gene information | Species | Human | Gene symbol | RGS12 | Gene ID | 6002 |
Gene name | regulator of G protein signaling 12 | |
Gene Alias | RGS12 | |
Cytomap | 4p16.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | O14924 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6002 | RGS12 | LZE4T | Human | Esophagus | ESCC | 8.69e-06 | -2.61e-02 | 0.0811 |
6002 | RGS12 | LZE7T | Human | Esophagus | ESCC | 1.86e-08 | 2.43e-01 | 0.0667 |
6002 | RGS12 | LZE8T | Human | Esophagus | ESCC | 9.22e-08 | 1.38e-01 | 0.067 |
6002 | RGS12 | LZE20T | Human | Esophagus | ESCC | 4.52e-09 | 2.36e-01 | 0.0662 |
6002 | RGS12 | LZE22T | Human | Esophagus | ESCC | 1.51e-02 | 1.96e-01 | 0.068 |
6002 | RGS12 | LZE21T | Human | Esophagus | ESCC | 3.77e-04 | 1.47e-01 | 0.0655 |
6002 | RGS12 | P1T-E | Human | Esophagus | ESCC | 2.86e-16 | 5.44e-01 | 0.0875 |
6002 | RGS12 | P2T-E | Human | Esophagus | ESCC | 2.24e-24 | 5.39e-01 | 0.1177 |
6002 | RGS12 | P4T-E | Human | Esophagus | ESCC | 5.13e-16 | 9.11e-02 | 0.1323 |
6002 | RGS12 | P5T-E | Human | Esophagus | ESCC | 2.10e-13 | -3.10e-02 | 0.1327 |
6002 | RGS12 | P8T-E | Human | Esophagus | ESCC | 1.92e-17 | 3.73e-01 | 0.0889 |
6002 | RGS12 | P9T-E | Human | Esophagus | ESCC | 1.96e-15 | 1.25e-01 | 0.1131 |
6002 | RGS12 | P10T-E | Human | Esophagus | ESCC | 4.30e-16 | 3.48e-01 | 0.116 |
6002 | RGS12 | P11T-E | Human | Esophagus | ESCC | 1.87e-09 | 2.84e-01 | 0.1426 |
6002 | RGS12 | P12T-E | Human | Esophagus | ESCC | 3.56e-19 | 3.28e-01 | 0.1122 |
6002 | RGS12 | P15T-E | Human | Esophagus | ESCC | 1.60e-08 | 1.32e-01 | 0.1149 |
6002 | RGS12 | P16T-E | Human | Esophagus | ESCC | 2.23e-53 | 1.12e+00 | 0.1153 |
6002 | RGS12 | P17T-E | Human | Esophagus | ESCC | 4.40e-10 | 4.03e-01 | 0.1278 |
6002 | RGS12 | P20T-E | Human | Esophagus | ESCC | 3.82e-20 | 1.28e-01 | 0.1124 |
6002 | RGS12 | P21T-E | Human | Esophagus | ESCC | 7.98e-21 | 9.83e-02 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RGS12 | SNV | Missense_Mutation | c.753N>A | p.Ser251Arg | p.S251R | O14924 | protein_coding | deleterious(0.01) | probably_damaging(0.957) | TCGA-A2-A0SU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
RGS12 | SNV | Missense_Mutation | rs747626425 | c.1946N>T | p.Ser649Leu | p.S649L | O14924 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
RGS12 | SNV | Missense_Mutation | c.4267N>C | p.Asp1423His | p.D1423H | O14924 | protein_coding | deleterious_low_confidence(0.01) | benign(0.157) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RGS12 | SNV | Missense_Mutation | novel | c.2879C>A | p.Ala960Asp | p.A960D | O14924 | protein_coding | tolerated(0.19) | possibly_damaging(0.477) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RGS12 | SNV | Missense_Mutation | c.162N>G | p.Asp54Glu | p.D54E | O14924 | protein_coding | tolerated(0.13) | benign(0.138) | TCGA-B6-A0X5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
RGS12 | SNV | Missense_Mutation | novel | c.2416N>A | p.Gln806Lys | p.Q806K | O14924 | protein_coding | deleterious(0.01) | possibly_damaging(0.741) | TCGA-BH-A0C0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
RGS12 | SNV | Missense_Mutation | rs748051902 | c.1859N>A | p.Arg620Gln | p.R620Q | O14924 | protein_coding | tolerated(0.25) | benign(0.007) | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
RGS12 | SNV | Missense_Mutation | rs750469659 | c.1418N>A | p.Thr473Asn | p.T473N | O14924 | protein_coding | tolerated(1) | benign(0) | TCGA-UU-A93S-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
RGS12 | insertion | Nonsense_Mutation | novel | c.3393_3394insTTTCAAATGGCAAGTTGACTCTAGAGCACCACATTGATATTG | p.Ser1131_Arg1132insPheGlnMetAlaSerTerLeuTerSerThrThrLeuIleLeu | p.S1131_R1132insFQMAS*L*STTLIL | O14924 | protein_coding | TCGA-BH-A0H9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
RGS12 | SNV | Missense_Mutation | novel | c.761C>T | p.Ala254Val | p.A254V | O14924 | protein_coding | tolerated(0.06) | possibly_damaging(0.462) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6002 | RGS12 | DRUGGABLE GENOME | LAVENDUSTIN C | LAVENDUSTIN C | ||
6002 | RGS12 | DRUGGABLE GENOME | SANGUINARIUM | SANGUINARIUM | ||
6002 | RGS12 | DRUGGABLE GENOME | MMV009085 | CHEMBL581225 | ||
6002 | RGS12 | DRUGGABLE GENOME | SANGUINARINE SULFATE | SANGUINARINE SULFATE |
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