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Gene: RETNLB |
Gene summary for RETNLB |
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Gene information | Species | Human | Gene symbol | RETNLB | Gene ID | 84666 |
Gene name | resistin like beta | |
Gene Alias | FIZZ1 | |
Cytomap | 3q13.13 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q9BQ08 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84666 | RETNLB | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.71e-08 | 2.66e-01 | 0.0155 |
84666 | RETNLB | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.33e-13 | 7.86e-01 | 0.0216 |
84666 | RETNLB | HTA11_78_2000001011 | Human | Colorectum | AD | 5.16e-09 | 8.63e-01 | -0.1088 |
84666 | RETNLB | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.16e-05 | 5.49e-01 | -0.1207 |
84666 | RETNLB | HTA11_696_2000001011 | Human | Colorectum | AD | 9.00e-36 | 1.22e+00 | -0.1464 |
84666 | RETNLB | HTA11_866_2000001011 | Human | Colorectum | AD | 1.84e-22 | 1.33e+00 | -0.1001 |
84666 | RETNLB | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.48e-06 | 9.14e-01 | -0.059 |
84666 | RETNLB | HTA11_866_3004761011 | Human | Colorectum | AD | 7.98e-07 | 2.83e-01 | 0.096 |
84666 | RETNLB | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.90e-02 | 1.31e-01 | 0.0674 |
84666 | RETNLB | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.79e-09 | 4.38e-01 | 0.0588 |
84666 | RETNLB | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.04e-13 | 3.70e-01 | 0.294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0050673 | Colorectum | AD | epithelial cell proliferation | 119/3918 | 437/18723 | 8.75e-04 | 8.51e-03 | 119 |
GO:00506731 | Colorectum | MSS | epithelial cell proliferation | 108/3467 | 437/18723 | 6.76e-04 | 7.30e-03 | 108 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RETNLB | SNV | Missense_Mutation | c.188G>C | p.Arg63Thr | p.R63T | Q9BQ08 | protein_coding | tolerated(0.41) | benign(0.007) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR | |
RETNLB | SNV | Missense_Mutation | c.235N>A | p.Gly79Ser | p.G79S | Q9BQ08 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E2-A15T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
RETNLB | SNV | Missense_Mutation | c.238N>C | p.Tyr80His | p.Y80H | Q9BQ08 | protein_coding | deleterious(0.05) | possibly_damaging(0.449) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RETNLB | SNV | Missense_Mutation | c.306G>C | p.Trp102Cys | p.W102C | Q9BQ08 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-QG-A5YV-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | CR | |
RETNLB | SNV | Missense_Mutation | c.25C>A | p.Leu9Ile | p.L9I | Q9BQ08 | protein_coding | deleterious(0.03) | possibly_damaging(0.563) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RETNLB | SNV | Missense_Mutation | novel | c.13N>G | p.Ser5Ala | p.S5A | Q9BQ08 | protein_coding | tolerated(0.73) | benign(0.026) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RETNLB | SNV | Missense_Mutation | novel | c.44N>C | p.Leu15Pro | p.L15P | Q9BQ08 | protein_coding | tolerated(0.15) | benign(0.153) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
RETNLB | insertion | In_Frame_Ins | novel | c.8_9insAAGGGA | p.Pro3_Ser4insArgGlu | p.P3_S4insRE | Q9BQ08 | protein_coding | TCGA-B5-A11I-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | PD | ||
RETNLB | SNV | Missense_Mutation | c.213N>T | p.Met71Ile | p.M71I | Q9BQ08 | protein_coding | tolerated(0.15) | benign(0.131) | TCGA-05-4398-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | |
RETNLB | SNV | Missense_Mutation | novel | c.292A>G | p.Ser98Gly | p.S98G | Q9BQ08 | protein_coding | tolerated(0.07) | benign(0.255) | TCGA-55-8208-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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