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Gene: REP15 |
Gene summary for REP15 |
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Gene information | Species | Human | Gene symbol | REP15 | Gene ID | 387849 |
Gene name | RAB15 effector protein | |
Gene Alias | RAB15EP | |
Cytomap | 12p11.22 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | Q6BDI9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
387849 | REP15 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.64e-02 | 1.65e-01 | -0.1088 |
387849 | REP15 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.00e-05 | 1.45e-01 | -0.1464 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043112 | Colorectum | AD | receptor metabolic process | 62/3918 | 166/18723 | 8.18e-07 | 2.85e-05 | 62 |
GO:0001881 | Colorectum | AD | receptor recycling | 18/3918 | 33/18723 | 2.23e-05 | 4.40e-04 | 18 |
GO:0033572 | Colorectum | AD | transferrin transport | 7/3918 | 10/18723 | 1.15e-03 | 1.04e-02 | 7 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
REP15 | SNV | Missense_Mutation | c.50N>C | p.Val17Ala | p.V17A | Q6BDI9 | protein_coding | tolerated(0.37) | benign(0.003) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
REP15 | SNV | Missense_Mutation | novel | c.511N>C | p.Lys171Gln | p.K171Q | Q6BDI9 | protein_coding | deleterious(0.01) | possibly_damaging(0.466) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
REP15 | SNV | Missense_Mutation | c.210N>T | p.Lys70Asn | p.K70N | Q6BDI9 | protein_coding | tolerated(0.07) | benign(0.009) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
REP15 | SNV | Missense_Mutation | novel | c.533N>G | p.Val178Gly | p.V178G | Q6BDI9 | protein_coding | deleterious(0) | benign(0.264) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
REP15 | SNV | Missense_Mutation | c.476G>C | p.Cys159Ser | p.C159S | Q6BDI9 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
REP15 | SNV | Missense_Mutation | novel | c.71N>C | p.Val24Ala | p.V24A | Q6BDI9 | protein_coding | deleterious(0.04) | benign(0.088) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
REP15 | SNV | Missense_Mutation | rs778847316 | c.500G>T | p.Gly167Val | p.G167V | Q6BDI9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
REP15 | SNV | Missense_Mutation | c.110A>T | p.Glu37Val | p.E37V | Q6BDI9 | protein_coding | deleterious(0.01) | benign(0.408) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
REP15 | SNV | Missense_Mutation | c.91G>T | p.Ala31Ser | p.A31S | Q6BDI9 | protein_coding | deleterious(0.01) | probably_damaging(0.966) | TCGA-95-A4VK-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
REP15 | SNV | Missense_Mutation | c.226C>A | p.Leu76Met | p.L76M | Q6BDI9 | protein_coding | deleterious(0.01) | possibly_damaging(0.885) | TCGA-46-3769-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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