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Gene: REG1B |
Gene summary for REG1B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | REG1B | Gene ID | 5968 |
| Gene name | regenerating family member 1 beta | |
| Gene Alias | PSPS2 | |
| Cytomap | 2p12 | |
| Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | P48304 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 5968 | REG1B | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.20e-02 | 3.15e-01 | 0.0155 |
| 5968 | REG1B | HTA11_696_2000001011 | Human | Colorectum | AD | 9.32e-10 | 6.10e-01 | -0.1464 |
| 5968 | REG1B | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.70e-18 | 1.36e+00 | -0.059 |
| 5968 | REG1B | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.15e-20 | 4.80e-01 | 0.294 |
| 5968 | REG1B | HTA12-15-2 | Human | Pancreas | PDAC | 5.45e-46 | -2.55e+00 | 0.2315 |
| 5968 | REG1B | HTA12-16-2 | Human | Pancreas | PDAC | 7.72e-12 | -2.25e+00 | 0.0535 |
| 5968 | REG1B | HTA12-16-5 | Human | Pancreas | PDAC | 2.78e-63 | -2.39e+00 | 0.047 |
| 5968 | REG1B | HTA12-16-6 | Human | Pancreas | PDAC | 5.35e-12 | -2.18e+00 | 0.0544 |
| 5968 | REG1B | HTA12-18-3 | Human | Pancreas | PDAC | 1.11e-21 | -2.46e+00 | 0.0716 |
| 5968 | REG1B | HTA12-23-1 | Human | Pancreas | PDAC | 1.96e-32 | -2.55e+00 | 0.3405 |
| 5968 | REG1B | HTA12-25-1 | Human | Pancreas | PDAC | 3.80e-45 | -2.55e+00 | 0.313 |
| 5968 | REG1B | HTA12-26-1 | Human | Pancreas | PDAC | 4.86e-54 | -2.55e+00 | 0.3728 |
| 5968 | REG1B | HTA12-29-1 | Human | Pancreas | PDAC | 1.64e-122 | -2.55e+00 | 0.3722 |
| 5968 | REG1B | HTA12-3-16 | Human | Pancreas | PDAC | 3.03e-11 | -2.55e+00 | 0.1553 |
| 5968 | REG1B | HTA12-30-1 | Human | Pancreas | PDAC | 1.56e-12 | -2.55e+00 | 0.3671 |
| 5968 | REG1B | HTA12-32-1 | Human | Pancreas | PDAC | 1.92e-17 | -2.55e+00 | 0.3624 |
| 5968 | REG1B | HTA12-9-1 | Human | Pancreas | PDAC | 1.26e-69 | -2.48e+00 | 0.1532 |
| 5968 | REG1B | HTA12-9-2 | Human | Pancreas | PDAC | 4.79e-43 | -1.14e+00 | 0.0835 |
| 5968 | REG1B | HTA12-9-3 | Human | Pancreas | PDAC | 4.18e-38 | -2.55e+00 | 0.2045 |
| 5968 | REG1B | 3829-EC | Human | Pancreas | PanIN | 1.01e-15 | 1.20e-01 | 0.009 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
| GO:0035821 | Colorectum | AD | modulation of process of other organism | 34/3918 | 106/18723 | 4.73e-03 | 3.22e-02 | 34 |
| GO:00434342 | Colorectum | MSS | response to peptide hormone | 104/3467 | 414/18723 | 4.58e-04 | 5.43e-03 | 104 |
| GO:00358211 | Colorectum | MSS | modulation of process of other organism | 33/3467 | 106/18723 | 1.18e-03 | 1.14e-02 | 33 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| REG1B | SNV | Missense_Mutation | c.17C>T | p.Ser6Leu | p.S6L | P48304 | protein_coding | tolerated(0.45) | benign(0) | TCGA-A2-A04N-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | |
| REG1B | SNV | Missense_Mutation | novel | c.377C>A | p.Thr126Asn | p.T126N | P48304 | protein_coding | tolerated(0.48) | benign(0.025) | TCGA-AC-A23G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR |
| REG1B | SNV | Missense_Mutation | c.218N>A | p.Val73Glu | p.V73E | P48304 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-E9-A22E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphane | SD | |
| REG1B | SNV | Missense_Mutation | c.170N>T | p.Trp57Leu | p.W57L | P48304 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DS-A0VM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
| REG1B | SNV | Missense_Mutation | c.458N>G | p.Ser153Cys | p.S153C | P48304 | protein_coding | deleterious(0.01) | possibly_damaging(0.573) | TCGA-FU-A3NI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| REG1B | SNV | Missense_Mutation | c.181N>T | p.Asp61Tyr | p.D61Y | P48304 | protein_coding | deleterious(0.04) | probably_damaging(0.981) | TCGA-AA-3678-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | CR | |
| REG1B | SNV | Missense_Mutation | rs539158429 | c.325N>T | p.Arg109Cys | p.R109C | P48304 | protein_coding | tolerated(0.13) | benign(0.011) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| REG1B | SNV | Missense_Mutation | c.441N>T | p.Lys147Asn | p.K147N | P48304 | protein_coding | tolerated(0.14) | benign(0.243) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
| REG1B | SNV | Missense_Mutation | rs141167987 | c.329N>A | p.Arg110His | p.R110H | P48304 | protein_coding | tolerated(0.21) | benign(0.015) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| REG1B | SNV | Missense_Mutation | novel | c.341N>T | p.Ser114Ile | p.S114I | P48304 | protein_coding | deleterious(0.03) | possibly_damaging(0.645) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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