Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: RECQL

Gene summary for RECQL

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

RECQL

Gene ID

5965

Gene nameRecQ like helicase
Gene AliasRECQL1
Cytomap12p12.1
Gene Typeprotein-coding
GO ID

GO:0000724

UniProtAcc

A0A024RAV2


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
5965RECQLLZE4THumanEsophagusESCC6.11e-031.15e-010.0811
5965RECQLLZE7THumanEsophagusESCC5.33e-054.46e-010.0667
5965RECQLLZE24THumanEsophagusESCC1.95e-071.58e-010.0596
5965RECQLP1T-EHumanEsophagusESCC8.72e-061.67e-010.0875
5965RECQLP2T-EHumanEsophagusESCC5.80e-285.59e-010.1177
5965RECQLP4T-EHumanEsophagusESCC6.60e-256.61e-010.1323
5965RECQLP5T-EHumanEsophagusESCC1.57e-162.38e-010.1327
5965RECQLP8T-EHumanEsophagusESCC2.98e-264.74e-010.0889
5965RECQLP9T-EHumanEsophagusESCC7.24e-071.80e-010.1131
5965RECQLP10T-EHumanEsophagusESCC4.53e-224.25e-010.116
5965RECQLP11T-EHumanEsophagusESCC1.71e-092.43e-010.1426
5965RECQLP12T-EHumanEsophagusESCC2.34e-264.66e-010.1122
5965RECQLP15T-EHumanEsophagusESCC1.07e-111.49e-010.1149
5965RECQLP16T-EHumanEsophagusESCC2.67e-368.97e-010.1153
5965RECQLP17T-EHumanEsophagusESCC4.18e-063.89e-010.1278
5965RECQLP19T-EHumanEsophagusESCC1.24e-076.44e-010.1662
5965RECQLP20T-EHumanEsophagusESCC1.24e-082.34e-010.1124
5965RECQLP21T-EHumanEsophagusESCC1.98e-263.78e-010.1617
5965RECQLP22T-EHumanEsophagusESCC1.48e-407.98e-010.1236
5965RECQLP23T-EHumanEsophagusESCC4.95e-153.57e-010.108
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:000705911EsophagusESCCchromosome segregation238/8552346/187231.72e-181.82e-16238
GO:00062604EsophagusESCCDNA replication181/8552260/187233.55e-152.05e-13181
GO:000635414EsophagusESCCDNA-templated transcription, elongation76/855291/187238.35e-144.11e-1276
GO:005105215EsophagusESCCregulation of DNA metabolic process232/8552359/187232.40e-131.13e-11232
GO:000072319EsophagusESCCtelomere maintenance99/8552131/187232.68e-121.08e-1099
GO:2001020110EsophagusESCCregulation of response to DNA damage stimulus145/8552219/187235.97e-101.50e-08145
GO:000636814EsophagusESCCtranscription elongation from RNA polymerase II promoter56/855269/187231.40e-093.30e-0856
GO:003278412EsophagusESCCregulation of DNA-templated transcription, elongation45/855253/187233.64e-097.61e-0845
GO:00062612EsophagusESCCDNA-dependent DNA replication100/8552151/187232.61e-073.94e-06100
GO:003424312EsophagusESCCregulation of transcription elongation from RNA polymerase II promoter28/855232/187231.02e-061.29e-0528
GO:00063024EsophagusESCCdouble-strand break repair152/8552251/187231.33e-061.62e-05152
GO:003239214EsophagusESCCDNA geometric change62/855290/187237.02e-067.04e-0562
GO:003250813EsophagusESCCDNA duplex unwinding58/855284/187231.23e-051.14e-0458
GO:003220014EsophagusESCCtelomere organization99/8552159/187231.77e-051.57e-0499
GO:00513042EsophagusESCCchromosome separation64/855296/187232.61e-052.20e-0464
GO:000941020EsophagusESCCresponse to xenobiotic stimulus253/8552462/187234.55e-053.58e-04253
GO:00062826EsophagusESCCregulation of DNA repair82/8552130/187234.65e-053.66e-0482
GO:200102112EsophagusESCCnegative regulation of response to DNA damage stimulus54/855281/187231.09e-047.64e-0454
GO:00063101EsophagusESCCDNA recombination168/8552305/187235.58e-043.05e-03168
GO:003424411EsophagusESCCnegative regulation of transcription elongation from RNA polymerase II promoter14/855216/187236.78e-043.56e-0314
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
RECQLSNVMissense_Mutationnovelc.1494N>Tp.Lys498Asnp.K498NP46063protein_codingtolerated(0.1)benign(0.242)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
RECQLSNVMissense_Mutationnovelc.32N>Cp.Leu11Prop.L11PP46063protein_codingdeleterious(0)probably_damaging(0.996)TCGA-AR-A0U2-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapytamoxiphenPD
RECQLSNVMissense_Mutationnovelc.715G>Cp.Gly239Argp.G239RP46063protein_codingdeleterious(0)probably_damaging(0.957)TCGA-AR-A250-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
RECQLSNVMissense_Mutationc.1603C>Tp.Pro535Serp.P535SP46063protein_codingdeleterious(0.01)benign(0.442)TCGA-BH-A18V-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
RECQLSNVMissense_Mutationc.857N>Ap.Leu286Glnp.L286QP46063protein_codingdeleterious(0)probably_damaging(0.999)TCGA-E9-A1NF-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinPD
RECQLinsertionNonsense_Mutationnovelc.84_85insCACTGAAATGGGGTACp.Thr29HisfsTer2p.T29Hfs*2P46063protein_codingTCGA-A2-A0CP-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
RECQLinsertionNonsense_Mutationnovelc.624_625insTAATAp.Glu209Terp.E209*P46063protein_codingTCGA-A7-A26I-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapycytoxanSD
RECQLinsertionNonsense_Mutationnovelc.713_714insGGTCTCTTAATAATTGGGTTATCAGTp.Gly239ValfsTer3p.G239Vfs*3P46063protein_codingTCGA-AN-A0FX-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
RECQLinsertionFrame_Shift_Insnovelc.812_813insATTAAATCTATTCp.Glu272LeufsTer5p.E272Lfs*5P46063protein_codingTCGA-AR-A0U0-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
RECQLSNVMissense_Mutationc.241G>Tp.Asp81Tyrp.D81YP46063protein_codingdeleterious(0.02)benign(0.028)TCGA-FU-A3HZ-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
5965RECQLDRUGGABLE GENOME, DNA REPAIR, ENZYMEPURPURINPURPURIN
5965RECQLDRUGGABLE GENOME, DNA REPAIR, ENZYMEELLIPTECINEELLIPTECINE
5965RECQLDRUGGABLE GENOME, DNA REPAIR, ENZYMELEVONORDEFRINLEVONORDEFRIN
5965RECQLDRUGGABLE GENOME, DNA REPAIR, ENZYMESTICTIC ACIDSTICTIC ACID
5965RECQLDRUGGABLE GENOME, DNA REPAIR, ENZYMEGNF-PF-5159CHEMBL1493528
5965RECQLDRUGGABLE GENOME, DNA REPAIR, ENZYMENSC-228155CHEMBL505670
5965RECQLDRUGGABLE GENOME, DNA REPAIR, ENZYMEVERAPAMIL HYDROCHLORIDEVERAPAMIL HYDROCHLORIDE
5965RECQLDRUGGABLE GENOME, DNA REPAIR, ENZYMEMMV009085CHEMBL581225
5965RECQLDRUGGABLE GENOME, DNA REPAIR, ENZYMEN-PHENETHYLCINNAMAMIDECHEMBL1305393
5965RECQLDRUGGABLE GENOME, DNA REPAIR, ENZYMEROSE BENGALROSE BENGAL
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