Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: RECK

Gene summary for RECK

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

RECK

Gene ID

8434

Gene namereversion inducing cysteine rich protein with kazal motifs
Gene AliasST15
Cytomap9p13.3
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

A8K9D8


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
8434RECKC04HumanOral cavityOSCC3.26e-024.08e-010.2633
8434RECKC21HumanOral cavityOSCC3.04e-051.82e-010.2678
8434RECKC30HumanOral cavityOSCC2.51e-177.28e-010.3055
8434RECKC06HumanOral cavityOSCC1.16e-026.13e-010.2699
8434RECKNEOLP-1HumanOral cavityNEOLP7.27e-042.49e-01-0.0194
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:005254720Oral cavityOSCCregulation of peptidase activity255/7305461/187235.78e-132.75e-11255
GO:005254820Oral cavityOSCCregulation of endopeptidase activity235/7305432/187234.35e-111.40e-09235
GO:001605510Oral cavityOSCCWnt signaling pathway227/7305444/187231.10e-071.87e-06227
GO:019873810Oral cavityOSCCcell-cell signaling by wnt227/7305446/187231.75e-072.86e-06227
GO:004586120Oral cavityOSCCnegative regulation of proteolysis181/7305351/187231.01e-061.37e-05181
GO:003011110Oral cavityOSCCregulation of Wnt signaling pathway165/7305328/187231.87e-051.80e-04165
GO:00902639Oral cavityOSCCpositive regulation of canonical Wnt signaling pathway62/7305106/187233.72e-053.31e-0462
GO:006082810Oral cavityOSCCregulation of canonical Wnt signaling pathway128/7305253/187231.11e-048.16e-04128
GO:005134618Oral cavityOSCCnegative regulation of hydrolase activity182/7305379/187231.98e-041.32e-03182
GO:001095117Oral cavityOSCCnegative regulation of endopeptidase activity126/7305252/187232.37e-041.54e-03126
GO:001046618Oral cavityOSCCnegative regulation of peptidase activity130/7305262/187232.89e-041.82e-03130
GO:006007010Oral cavityOSCCcanonical Wnt signaling pathway148/7305303/187232.89e-041.82e-03148
GO:00301983Oral cavityOSCCextracellular matrix organization146/7305301/187234.67e-042.77e-03146
GO:00452293Oral cavityOSCCexternal encapsulating structure organization147/7305304/187235.30e-043.08e-03147
GO:00430623Oral cavityOSCCextracellular structure organization146/7305302/187235.59e-043.23e-03146
GO:00075657Oral cavityOSCCfemale pregnancy98/7305193/187235.66e-043.27e-0398
GO:00301779Oral cavityOSCCpositive regulation of Wnt signaling pathway73/7305140/187231.06e-035.46e-0373
GO:00447067Oral cavityOSCCmulti-multicellular organism process105/7305220/187235.05e-031.97e-02105
GO:00075667Oral cavityOSCCembryo implantation29/730553/187231.46e-024.76e-0229
GO:005254733Oral cavityNEOLPregulation of peptidase activity98/2005461/187231.77e-112.56e-0998
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
RECKSNVMissense_Mutationnovelc.708N>Tp.Lys236Asnp.K236NO95980protein_codingtolerated(0.15)benign(0.062)TCGA-A2-A3XZ-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycarboplatinCR
RECKSNVMissense_Mutationc.1760N>Cp.Arg587Thrp.R587TO95980protein_codingdeleterious(0.04)benign(0.054)TCGA-B6-A0WZ-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownPD
RECKSNVMissense_Mutationc.1598N>Gp.Ser533Cysp.S533CO95980protein_codingdeleterious(0)probably_damaging(0.998)TCGA-BH-A0HP-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapydoxorubicinSD
RECKSNVMissense_Mutationc.1291N>Gp.Ile431Valp.I431VO95980protein_codingdeleterious(0.03)probably_damaging(0.987)TCGA-D8-A1XQ-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
RECKdeletionFrame_Shift_Delc.810_811delNNp.Val271SerfsTer18p.V271Sfs*18O95980protein_codingTCGA-A2-A04N-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapycytoxanSD
RECKdeletionFrame_Shift_Delnovelc.1201delGp.Asp401IlefsTer13p.D401Ifs*13O95980protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
RECKdeletionFrame_Shift_Delnovelc.2692delCp.Gln898ArgfsTer101p.Q898Rfs*101O95980protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
RECKSNVMissense_Mutationnovelc.455N>Ap.Cys152Tyrp.C152YO95980protein_codingdeleterious(0)probably_damaging(0.998)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
RECKSNVMissense_Mutationnovelc.2782N>Tp.Ala928Serp.A928SO95980protein_codingtolerated(0.19)benign(0.423)TCGA-EK-A2R7-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
RECKSNVMissense_Mutationrs142114378c.2143N>Ap.Ala715Thrp.A715TO95980protein_codingtolerated(0.75)benign(0)TCGA-EX-A1H5-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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