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Gene: RDH5 |
Gene summary for RDH5 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | RDH5 | Gene ID | 5959 |
| Gene name | retinol dehydrogenase 5 | |
| Gene Alias | 9cRDH | |
| Cytomap | 12q13.2 | |
| Gene Type | protein-coding | GO ID | GO:0001523 | UniProtAcc | A0A024RB18 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 5959 | RDH5 | PTC01 | Human | Thyroid | PTC | 6.38e-17 | 3.16e-01 | 0.1899 |
| 5959 | RDH5 | PTC04 | Human | Thyroid | PTC | 1.21e-04 | 1.72e-01 | 0.1927 |
| 5959 | RDH5 | PTC05 | Human | Thyroid | PTC | 5.53e-08 | 3.24e-01 | 0.2065 |
| 5959 | RDH5 | PTC06 | Human | Thyroid | PTC | 3.15e-09 | 2.53e-01 | 0.2057 |
| 5959 | RDH5 | PTC07 | Human | Thyroid | PTC | 2.76e-08 | 2.21e-01 | 0.2044 |
| 5959 | RDH5 | ATC13 | Human | Thyroid | ATC | 7.40e-31 | 5.32e-01 | 0.34 |
| 5959 | RDH5 | ATC5 | Human | Thyroid | ATC | 4.66e-32 | 5.62e-01 | 0.34 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| RDH5 | SNV | Missense_Mutation | c.121N>T | p.Gly41Trp | p.G41W | Q92781 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AR-A0TP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
| RDH5 | deletion | Frame_Shift_Del | novel | c.839_866delNNNNNNNNNNNNNNNNNNNNNNNNNNNN | p.Tyr281SerfsTer64 | p.Y281Sfs*64 | Q92781 | protein_coding | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | |||
| RDH5 | insertion | Frame_Shift_Ins | novel | c.947_948insCATGTGGAACCTGCCCACTCCCCACACTGAGGAGGGGACTG | p.Val317MetfsTer51 | p.V317Mfs*51 | Q92781 | protein_coding | TCGA-A8-A07B-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| RDH5 | insertion | Frame_Shift_Ins | novel | c.952_953insC | p.Tyr318SerfsTer18 | p.Y318Sfs*18 | Q92781 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
| RDH5 | insertion | Frame_Shift_Ins | novel | c.953_954insCTATGTTGGCCAGGTTGGT | p.Ter319TyrfsTer23 | p.*319Yfs*23 | Q92781 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
| RDH5 | insertion | Frame_Shift_Ins | novel | c.516_517insG | p.Tyr175LeufsTer13 | p.Y175Lfs*13 | Q92781 | protein_coding | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| RDH5 | SNV | Missense_Mutation | novel | c.655G>C | p.Glu219Gln | p.E219Q | Q92781 | protein_coding | tolerated(0.43) | possibly_damaging(0.791) | TCGA-C5-A1BL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| RDH5 | SNV | Missense_Mutation | rs370781214 | c.56N>A | p.Arg19Lys | p.R19K | Q92781 | protein_coding | tolerated(0.06) | benign(0.293) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| RDH5 | SNV | Missense_Mutation | novel | c.860N>T | p.Ala287Val | p.A287V | Q92781 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| RDH5 | SNV | Missense_Mutation | c.624C>A | p.Phe208Leu | p.F208L | Q92781 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-G4-6299-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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