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Gene: RDH10 |
Gene summary for RDH10 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | RDH10 | Gene ID | 157506 |
| Gene name | retinol dehydrogenase 10 | |
| Gene Alias | SDR16C4 | |
| Cytomap | 8q21.11 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R7X6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 157506 | RDH10 | CA_HPV_1 | Human | Cervix | CC | 1.89e-03 | -1.78e-01 | 0.0264 |
| 157506 | RDH10 | CCI_2 | Human | Cervix | CC | 7.55e-05 | 9.15e-01 | 0.5249 |
| 157506 | RDH10 | H2 | Human | Cervix | HSIL_HPV | 1.17e-18 | 6.29e-01 | 0.0632 |
| 157506 | RDH10 | L1 | Human | Cervix | CC | 4.65e-08 | 5.69e-01 | 0.0802 |
| 157506 | RDH10 | AEH-subject1 | Human | Endometrium | AEH | 1.58e-20 | 5.80e-01 | -0.3059 |
| 157506 | RDH10 | AEH-subject2 | Human | Endometrium | AEH | 1.27e-04 | 3.46e-01 | -0.2525 |
| 157506 | RDH10 | AEH-subject3 | Human | Endometrium | AEH | 2.65e-29 | 7.72e-01 | -0.2576 |
| 157506 | RDH10 | AEH-subject4 | Human | Endometrium | AEH | 2.23e-07 | 4.46e-01 | -0.2657 |
| 157506 | RDH10 | AEH-subject5 | Human | Endometrium | AEH | 4.23e-03 | 3.21e-01 | -0.2953 |
| 157506 | RDH10 | EEC-subject1 | Human | Endometrium | EEC | 1.20e-07 | 3.36e-01 | -0.2682 |
| 157506 | RDH10 | EEC-subject2 | Human | Endometrium | EEC | 1.36e-11 | 4.51e-01 | -0.2607 |
| 157506 | RDH10 | EEC-subject3 | Human | Endometrium | EEC | 1.89e-02 | 2.04e-01 | -0.2525 |
| 157506 | RDH10 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 6.54e-07 | 2.91e-01 | -0.1869 |
| 157506 | RDH10 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 8.61e-08 | 3.33e-01 | -0.1875 |
| 157506 | RDH10 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 5.61e-12 | 3.97e-01 | -0.1883 |
| 157506 | RDH10 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 3.84e-06 | 2.96e-01 | -0.1934 |
| 157506 | RDH10 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 5.91e-10 | 1.73e-01 | -0.1917 |
| 157506 | RDH10 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.93e-07 | 2.29e-01 | -0.1916 |
| 157506 | RDH10 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 3.41e-13 | 4.48e-01 | -0.1269 |
| 157506 | RDH10 | LZE5T | Human | Esophagus | ESCC | 4.35e-05 | 1.09e+00 | 0.0514 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00614588 | Cervix | CC | reproductive system development | 87/2311 | 427/18723 | 1.37e-06 | 4.55e-05 | 87 |
| GO:00486088 | Cervix | CC | reproductive structure development | 86/2311 | 424/18723 | 1.90e-06 | 5.97e-05 | 86 |
| GO:00488634 | Cervix | CC | stem cell differentiation | 46/2311 | 206/18723 | 4.11e-05 | 6.36e-04 | 46 |
| GO:00017018 | Cervix | CC | in utero embryonic development | 71/2311 | 367/18723 | 7.21e-05 | 1.00e-03 | 71 |
| GO:00604253 | Cervix | CC | lung morphogenesis | 15/2311 | 50/18723 | 7.36e-04 | 6.60e-03 | 15 |
| GO:00605606 | Cervix | CC | developmental growth involved in morphogenesis | 46/2311 | 234/18723 | 8.82e-04 | 7.63e-03 | 46 |
| GO:00303245 | Cervix | CC | lung development | 36/2311 | 177/18723 | 1.64e-03 | 1.26e-02 | 36 |
| GO:00487365 | Cervix | CC | appendage development | 35/2311 | 172/18723 | 1.88e-03 | 1.39e-02 | 35 |
| GO:00601735 | Cervix | CC | limb development | 35/2311 | 172/18723 | 1.88e-03 | 1.39e-02 | 35 |
| GO:00303235 | Cervix | CC | respiratory tube development | 36/2311 | 181/18723 | 2.46e-03 | 1.71e-02 | 36 |
| GO:00605413 | Cervix | CC | respiratory system development | 39/2311 | 203/18723 | 3.18e-03 | 2.07e-02 | 39 |
| GO:00605626 | Cervix | CC | epithelial tube morphogenesis | 57/2311 | 325/18723 | 3.79e-03 | 2.41e-02 | 57 |
| GO:00017636 | Cervix | CC | morphogenesis of a branching structure | 37/2311 | 196/18723 | 5.36e-03 | 3.10e-02 | 37 |
| GO:00604412 | Cervix | CC | epithelial tube branching involved in lung morphogenesis | 9/2311 | 29/18723 | 6.49e-03 | 3.61e-02 | 9 |
| GO:0150063 | Cervix | CC | visual system development | 63/2311 | 375/18723 | 6.58e-03 | 3.65e-02 | 63 |
| GO:0001654 | Cervix | CC | eye development | 62/2311 | 371/18723 | 7.83e-03 | 4.13e-02 | 62 |
| GO:00487624 | Cervix | CC | mesenchymal cell differentiation | 42/2311 | 236/18723 | 9.12e-03 | 4.60e-02 | 42 |
| GO:0048880 | Cervix | CC | sensory system development | 63/2311 | 381/18723 | 9.29e-03 | 4.66e-02 | 63 |
| GO:004860813 | Cervix | HSIL_HPV | reproductive structure development | 32/737 | 424/18723 | 3.52e-04 | 5.54e-03 | 32 |
| GO:006145814 | Cervix | HSIL_HPV | reproductive system development | 32/737 | 427/18723 | 3.98e-04 | 6.14e-03 | 32 |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| RDH10 | SNV | Missense_Mutation | novel | c.983N>T | p.Arg328Ile | p.R328I | Q8IZV5 | protein_coding | tolerated(0.11) | benign(0.01) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| RDH10 | SNV | Missense_Mutation | c.616N>A | p.Gly206Arg | p.G206R | Q8IZV5 | protein_coding | tolerated(0.41) | benign(0.142) | TCGA-AO-A0J8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
| RDH10 | SNV | Missense_Mutation | c.861C>G | p.Ile287Met | p.I287M | Q8IZV5 | protein_coding | deleterious(0.01) | possibly_damaging(0.854) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| RDH10 | SNV | Missense_Mutation | c.955N>G | p.Lys319Glu | p.K319E | Q8IZV5 | protein_coding | tolerated(0.13) | benign(0.056) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| RDH10 | SNV | Missense_Mutation | c.607N>G | p.Ser203Gly | p.S203G | Q8IZV5 | protein_coding | tolerated(1) | benign(0.01) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
| RDH10 | SNV | Missense_Mutation | novel | c.769N>G | p.Arg257Gly | p.R257G | Q8IZV5 | protein_coding | deleterious(0.02) | benign(0.251) | TCGA-AA-3939-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| RDH10 | SNV | Missense_Mutation | c.707T>A | p.Ile236Asn | p.I236N | Q8IZV5 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| RDH10 | SNV | Missense_Mutation | c.686N>G | p.Lys229Arg | p.K229R | Q8IZV5 | protein_coding | tolerated(0.37) | benign(0.025) | TCGA-AG-A036-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
| RDH10 | SNV | Missense_Mutation | novel | c.692C>T | p.Ala231Val | p.A231V | Q8IZV5 | protein_coding | tolerated(0.28) | benign(0.014) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| RDH10 | SNV | Missense_Mutation | novel | c.841C>A | p.Leu281Ile | p.L281I | Q8IZV5 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| Page: 1 2 3 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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