|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: RCSD1 |
Gene summary for RCSD1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | RCSD1 | Gene ID | 92241 |
| Gene name | RCSD domain containing 1 | |
| Gene Alias | CAPZIP | |
| Cytomap | 1q24.2 | |
| Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | B7ZKW8 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 92241 | RCSD1 | HCC1 | Human | Liver | HCC | 1.67e-03 | 1.21e+00 | 0.5336 |
| 92241 | RCSD1 | HCC2 | Human | Liver | HCC | 2.47e-11 | 1.28e+00 | 0.5341 |
| 92241 | RCSD1 | HCC5 | Human | Liver | HCC | 6.08e-09 | 1.77e+00 | 0.4932 |
| 92241 | RCSD1 | Pt13.a | Human | Liver | HCC | 1.94e-07 | 1.87e-01 | 0.021 |
| 92241 | RCSD1 | Pt13.b | Human | Liver | HCC | 4.05e-10 | 2.39e-01 | 0.0251 |
| 92241 | RCSD1 | S014 | Human | Liver | HCC | 1.05e-12 | 5.44e-01 | 0.2254 |
| 92241 | RCSD1 | S015 | Human | Liver | HCC | 9.88e-08 | 4.29e-01 | 0.2375 |
| 92241 | RCSD1 | S016 | Human | Liver | HCC | 2.36e-14 | 4.45e-01 | 0.2243 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:006219722 | Liver | HCC | cellular response to chemical stress | 216/7958 | 337/18723 | 6.86e-16 | 5.44e-14 | 216 |
| GO:007121421 | Liver | HCC | cellular response to abiotic stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
| GO:010400421 | Liver | HCC | cellular response to environmental stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
| GO:00069702 | Liver | HCC | response to osmotic stress | 52/7958 | 84/18723 | 2.58e-04 | 1.92e-03 | 52 |
| GO:0071474 | Liver | HCC | cellular hyperosmotic response | 13/7958 | 15/18723 | 5.67e-04 | 3.61e-03 | 13 |
| GO:00714701 | Liver | HCC | cellular response to osmotic stress | 28/7958 | 41/18723 | 7.54e-04 | 4.55e-03 | 28 |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| RCSD1 | SNV | Missense_Mutation | c.321N>C | p.Lys107Asn | p.K107N | Q6JBY9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
| RCSD1 | SNV | Missense_Mutation | c.1157N>T | p.Gly386Val | p.G386V | Q6JBY9 | protein_coding | deleterious_low_confidence(0.01) | benign(0.003) | TCGA-AN-A0XS-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| RCSD1 | insertion | Nonsense_Mutation | novel | c.590_591insGCCGTCAGCAGGTCTCTAACCCTCTTCTCGGTGCGATTCATCT | p.Ala198ProfsTer6 | p.A198Pfs*6 | Q6JBY9 | protein_coding | TCGA-A8-A09D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | ||
| RCSD1 | SNV | Missense_Mutation | c.674N>A | p.Gly225Glu | p.G225E | Q6JBY9 | protein_coding | tolerated(0.13) | benign(0.001) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
| RCSD1 | SNV | Missense_Mutation | c.412G>A | p.Glu138Lys | p.E138K | Q6JBY9 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
| RCSD1 | SNV | Missense_Mutation | rs761266081 | c.215C>T | p.Ala72Val | p.A72V | Q6JBY9 | protein_coding | tolerated(0.13) | benign(0.055) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| RCSD1 | SNV | Missense_Mutation | c.1058N>T | p.Pro353Leu | p.P353L | Q6JBY9 | protein_coding | deleterious(0) | benign(0.42) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| RCSD1 | SNV | Missense_Mutation | c.761N>T | p.Ala254Val | p.A254V | Q6JBY9 | protein_coding | tolerated(0.06) | possibly_damaging(0.715) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| RCSD1 | SNV | Missense_Mutation | c.17C>T | p.Ala6Val | p.A6V | Q6JBY9 | protein_coding | deleterious(0.02) | benign(0.09) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |
| RCSD1 | deletion | Frame_Shift_Del | c.153delN | p.Leu53CysfsTer6 | p.L53Cfs*6 | Q6JBY9 | protein_coding | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 92241 | RCSD1 | NA | IMATINIB | IMATINIB | 27125982 |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |