Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: RCOR1

Gene summary for RCOR1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

RCOR1

Gene ID

23186

Gene nameREST corepressor 1
Gene AliasCOREST
Cytomap14q32.31-q32.32
Gene Typeprotein-coding
GO ID

GO:0002262

UniProtAcc

Q9UKL0


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
23186RCOR1CCI_1HumanCervixCC3.63e-171.43e+000.528
23186RCOR1CCI_2HumanCervixCC1.75e-068.39e-010.5249
23186RCOR1CCI_3HumanCervixCC1.26e-101.11e+000.516
23186RCOR1sample3HumanCervixCC1.59e-053.12e-010.1387
23186RCOR1T3HumanCervixCC1.46e-043.26e-010.1389
23186RCOR1HTA11_3410_2000001011HumanColorectumAD4.66e-17-6.26e-010.0155
23186RCOR1HTA11_7862_2000001011HumanColorectumAD1.96e-03-5.74e-01-0.0179
23186RCOR1HTA11_866_3004761011HumanColorectumAD2.95e-04-4.62e-010.096
23186RCOR1HTA11_7696_3000711011HumanColorectumAD2.42e-07-4.34e-010.0674
23186RCOR1HTA11_99999970781_79442HumanColorectumMSS2.72e-09-4.56e-010.294
23186RCOR1HTA11_99999971662_82457HumanColorectumMSS7.77e-18-5.88e-010.3859
23186RCOR1HTA11_99999973899_84307HumanColorectumMSS9.40e-09-7.56e-010.2585
23186RCOR1HTA11_99999974143_84620HumanColorectumMSS3.85e-19-6.48e-010.3005
23186RCOR1F007HumanColorectumFAP1.97e-02-3.23e-010.1176
23186RCOR1A002-C-010HumanColorectumFAP6.39e-03-3.23e-010.242
23186RCOR1A001-C-207HumanColorectumFAP6.93e-05-3.16e-010.1278
23186RCOR1A015-C-203HumanColorectumFAP2.12e-28-3.84e-01-0.1294
23186RCOR1A015-C-204HumanColorectumFAP2.27e-07-3.23e-01-0.0228
23186RCOR1A014-C-040HumanColorectumFAP1.86e-04-3.38e-01-0.1184
23186RCOR1A002-C-201HumanColorectumFAP6.38e-13-2.96e-010.0324
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:003009910CervixCCmyeloid cell differentiation83/2311381/187231.31e-076.42e-0683
GO:190370610CervixCCregulation of hemopoiesis80/2311367/187232.14e-079.55e-0680
GO:000226210CervixCCmyeloid cell homeostasis43/2311157/187232.66e-071.12e-0543
GO:003410110CervixCCerythrocyte homeostasis37/2311129/187235.16e-071.93e-0537
GO:003021810CervixCCerythrocyte differentiation34/2311120/187232.00e-066.18e-0534
GO:004887210CervixCChomeostasis of number of cells61/2311272/187232.17e-066.55e-0561
GO:004563710CervixCCregulation of myeloid cell differentiation48/2311210/187231.49e-052.93e-0448
GO:00456397CervixCCpositive regulation of myeloid cell differentiation28/2311103/187233.56e-055.70e-0428
GO:00165705CervixCChistone modification84/2311463/187231.70e-042.01e-0384
GO:0034101ColorectumADerythrocyte homeostasis51/3918129/187231.07e-063.59e-0551
GO:0030099ColorectumADmyeloid cell differentiation119/3918381/187231.24e-064.01e-05119
GO:0002262ColorectumADmyeloid cell homeostasis57/3918157/187236.17e-061.56e-0457
GO:0048872ColorectumADhomeostasis of number of cells87/3918272/187231.16e-052.61e-0487
GO:0030218ColorectumADerythrocyte differentiation45/3918120/187232.22e-054.39e-0445
GO:1903706ColorectumADregulation of hemopoiesis99/3918367/187233.08e-032.28e-0299
GO:0045637ColorectumADregulation of myeloid cell differentiation61/3918210/187233.17e-032.35e-0261
GO:00341012ColorectumMSSerythrocyte homeostasis49/3467129/187231.58e-077.19e-0649
GO:00300992ColorectumMSSmyeloid cell differentiation110/3467381/187234.48e-071.75e-05110
GO:00022622ColorectumMSSmyeloid cell homeostasis55/3467157/187236.35e-072.34e-0555
GO:00488722ColorectumMSShomeostasis of number of cells82/3467272/187232.02e-066.28e-0582
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0501618CervixCCHuntington disease94/1267306/84658.49e-133.06e-111.81e-1194
hsa0501619CervixCCHuntington disease94/1267306/84658.49e-133.06e-111.81e-1194
hsa05016ColorectumADHuntington disease147/2092306/84651.93e-199.26e-185.91e-18147
hsa050161ColorectumADHuntington disease147/2092306/84651.93e-199.26e-185.91e-18147
hsa050164ColorectumMSSHuntington disease141/1875306/84652.90e-211.62e-199.92e-20141
hsa050165ColorectumMSSHuntington disease141/1875306/84652.90e-211.62e-199.92e-20141
hsa050168ColorectumFAPHuntington disease73/1404306/84655.54e-043.93e-032.39e-0373
hsa050169ColorectumFAPHuntington disease73/1404306/84655.54e-043.93e-032.39e-0373
hsa0501620EndometriumAEHHuntington disease118/1197306/84653.00e-272.44e-251.78e-25118
hsa05016110EndometriumAEHHuntington disease118/1197306/84653.00e-272.44e-251.78e-25118
hsa0501625EndometriumEECHuntington disease120/1237306/84653.86e-274.23e-253.15e-25120
hsa0501635EndometriumEECHuntington disease120/1237306/84653.86e-274.23e-253.15e-25120
hsa05016210EsophagusESCCHuntington disease226/4205306/84651.38e-188.72e-174.46e-17226
hsa0501638EsophagusESCCHuntington disease226/4205306/84651.38e-188.72e-174.46e-17226
hsa0501628Oral cavityOSCCHuntington disease204/3704306/84651.70e-167.13e-153.63e-15204
hsa05016112Oral cavityOSCCHuntington disease204/3704306/84651.70e-167.13e-153.63e-15204
hsa0501645Oral cavityEOLPHuntington disease69/1218306/84656.32e-052.96e-041.75e-0469
hsa0501655Oral cavityEOLPHuntington disease69/1218306/84656.32e-052.96e-041.75e-0469
hsa0501612StomachGCHuntington disease69/708306/84656.71e-152.68e-131.89e-1369
hsa0501613StomachGCHuntington disease69/708306/84656.71e-152.68e-131.89e-1369
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
RCOR1AT2LungIACZBTB16,EXT1,AUTS2, etc.1.84e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
RCOR1MSC.MVAOral cavityOSCCDSC2,MXD1,GGA3, etc.2.72e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
RCOR1CD8TRMPancreasPDACZSWIM6,SIK3,IQCN, etc.1.92e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
RCOR1CD8TCMThyroidATCZNF282,CFP,ARMCX5, etc.3.34e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
RCOR1SNVMissense_Mutationc.481G>Tp.Gly161Trpp.G161Wprotein_codingdeleterious(0)probably_damaging(0.998)TCGA-A2-A0EM-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenSD
RCOR1insertionNonsense_Mutationnovelc.1033_1034insAGTGACCAGGAGGGAAAATGCAp.Leu345Terp.L345*protein_codingTCGA-AO-A128-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
RCOR1SNVMissense_Mutationc.862C>Tp.Pro288Serp.P288Sprotein_codingtolerated(0.39)benign(0.39)TCGA-FU-A3HY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
RCOR1SNVMissense_Mutationnovelc.755N>Gp.Lys252Argp.K252Rprotein_codingtolerated(0.28)possibly_damaging(0.458)TCGA-CM-5348-01Colorectumcolon adenocarcinomaMale>=65III/IVUnknownUnknownSD
RCOR1SNVMissense_Mutationnovelc.926N>Tp.Ala309Valp.A309Vprotein_codingtolerated(0.35)possibly_damaging(0.793)TCGA-G4-6320-01Colorectumcolon adenocarcinomaMale>=65III/IVChemotherapyoxaliplatinSD
RCOR1SNVMissense_Mutationnovelc.1276A>Cp.Asn426Hisp.N426Hprotein_codingdeleterious(0.03)possibly_damaging(0.904)TCGA-AG-A002-01Colorectumrectum adenocarcinomaMale<65I/IIUnknownUnknownSD
RCOR1SNVMissense_Mutationrs781137761c.535G>Ap.Glu179Lysp.E179Kprotein_codingdeleterious(0)possibly_damaging(0.739)TCGA-AG-A01J-01Colorectumrectum adenocarcinomaFemale<65I/IIUnknownUnknownSD
RCOR1SNVMissense_Mutationc.1289N>Ap.Arg430Hisp.R430Hprotein_codingdeleterious(0)probably_damaging(0.998)TCGA-EI-6882-01Colorectumrectum adenocarcinomaMale<65I/IIUnknownUnknownSD
RCOR1SNVMissense_Mutationnovelc.1267T>Gp.Phe423Valp.F423Vprotein_codingdeleterious(0)probably_damaging(0.999)TCGA-A5-A1OF-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
RCOR1SNVMissense_Mutationnovelc.743G>Ap.Arg248Hisp.R248Hprotein_codingdeleterious(0)probably_damaging(0.999)TCGA-AP-A051-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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