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Gene: RCE1 |
Gene summary for RCE1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | RCE1 | Gene ID | 9986 |
| Gene name | Ras converting CAAX endopeptidase 1 | |
| Gene Alias | FACE2 | |
| Cytomap | 11q13.2 | |
| Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A0A024R5B6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9986 | RCE1 | LZE4T | Human | Esophagus | ESCC | 4.88e-03 | 1.31e-01 | 0.0811 |
| 9986 | RCE1 | LZE7T | Human | Esophagus | ESCC | 2.65e-03 | 1.95e-01 | 0.0667 |
| 9986 | RCE1 | LZE20T | Human | Esophagus | ESCC | 3.70e-12 | 7.00e-01 | 0.0662 |
| 9986 | RCE1 | LZE22T | Human | Esophagus | ESCC | 3.40e-03 | 4.19e-01 | 0.068 |
| 9986 | RCE1 | LZE24T | Human | Esophagus | ESCC | 1.06e-29 | 8.22e-01 | 0.0596 |
| 9986 | RCE1 | P1T-E | Human | Esophagus | ESCC | 7.86e-07 | 4.08e-01 | 0.0875 |
| 9986 | RCE1 | P2T-E | Human | Esophagus | ESCC | 3.74e-23 | 4.72e-01 | 0.1177 |
| 9986 | RCE1 | P4T-E | Human | Esophagus | ESCC | 2.82e-28 | 7.27e-01 | 0.1323 |
| 9986 | RCE1 | P5T-E | Human | Esophagus | ESCC | 1.59e-45 | 8.87e-01 | 0.1327 |
| 9986 | RCE1 | P8T-E | Human | Esophagus | ESCC | 3.33e-44 | 7.51e-01 | 0.0889 |
| 9986 | RCE1 | P9T-E | Human | Esophagus | ESCC | 5.47e-11 | 3.13e-01 | 0.1131 |
| 9986 | RCE1 | P10T-E | Human | Esophagus | ESCC | 5.03e-21 | 3.18e-01 | 0.116 |
| 9986 | RCE1 | P11T-E | Human | Esophagus | ESCC | 4.91e-22 | 9.29e-01 | 0.1426 |
| 9986 | RCE1 | P12T-E | Human | Esophagus | ESCC | 1.19e-24 | 5.15e-01 | 0.1122 |
| 9986 | RCE1 | P15T-E | Human | Esophagus | ESCC | 5.14e-30 | 6.96e-01 | 0.1149 |
| 9986 | RCE1 | P16T-E | Human | Esophagus | ESCC | 4.24e-43 | 6.50e-01 | 0.1153 |
| 9986 | RCE1 | P17T-E | Human | Esophagus | ESCC | 4.95e-11 | 4.63e-01 | 0.1278 |
| 9986 | RCE1 | P19T-E | Human | Esophagus | ESCC | 1.29e-05 | 5.01e-01 | 0.1662 |
| 9986 | RCE1 | P20T-E | Human | Esophagus | ESCC | 1.60e-34 | 8.53e-01 | 0.1124 |
| 9986 | RCE1 | P21T-E | Human | Esophagus | ESCC | 6.17e-45 | 9.01e-01 | 0.1617 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00224119 | Breast | Precancer | cellular component disassembly | 44/1080 | 443/18723 | 3.17e-04 | 4.51e-03 | 44 |
| GO:00329865 | Breast | Precancer | protein-DNA complex disassembly | 6/1080 | 20/18723 | 6.99e-04 | 8.43e-03 | 6 |
| GO:003298612 | Breast | IDC | protein-DNA complex disassembly | 6/1434 | 20/18723 | 3.03e-03 | 2.60e-02 | 6 |
| GO:003298621 | Breast | DCIS | protein-DNA complex disassembly | 6/1390 | 20/18723 | 2.59e-03 | 2.30e-02 | 6 |
| GO:002241113 | Breast | DCIS | cellular component disassembly | 48/1390 | 443/18723 | 5.35e-03 | 3.92e-02 | 48 |
| GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
| GO:0032984 | Colorectum | AD | protein-containing complex disassembly | 81/3918 | 224/18723 | 9.41e-08 | 4.65e-06 | 81 |
| GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
| GO:0032986 | Colorectum | AD | protein-DNA complex disassembly | 12/3918 | 20/18723 | 1.60e-04 | 2.21e-03 | 12 |
| GO:0031498 | Colorectum | AD | chromatin disassembly | 11/3918 | 20/18723 | 8.39e-04 | 8.21e-03 | 11 |
| GO:0006337 | Colorectum | AD | nucleosome disassembly | 10/3918 | 18/18723 | 1.31e-03 | 1.15e-02 | 10 |
| GO:0006338 | Colorectum | AD | chromatin remodeling | 70/3918 | 255/18723 | 7.44e-03 | 4.53e-02 | 70 |
| GO:00224111 | Colorectum | SER | cellular component disassembly | 114/2897 | 443/18723 | 1.17e-08 | 9.59e-07 | 114 |
| GO:00329841 | Colorectum | SER | protein-containing complex disassembly | 61/2897 | 224/18723 | 4.17e-06 | 1.60e-04 | 61 |
| GO:00063251 | Colorectum | SER | chromatin organization | 89/2897 | 409/18723 | 4.15e-04 | 6.17e-03 | 89 |
| GO:00314981 | Colorectum | SER | chromatin disassembly | 8/2897 | 20/18723 | 7.14e-03 | 4.99e-02 | 8 |
| GO:00329861 | Colorectum | SER | protein-DNA complex disassembly | 8/2897 | 20/18723 | 7.14e-03 | 4.99e-02 | 8 |
| GO:00224112 | Colorectum | MSS | cellular component disassembly | 130/3467 | 443/18723 | 1.44e-08 | 8.46e-07 | 130 |
| GO:00329842 | Colorectum | MSS | protein-containing complex disassembly | 69/3467 | 224/18723 | 5.61e-06 | 1.50e-04 | 69 |
| GO:00329862 | Colorectum | MSS | protein-DNA complex disassembly | 12/3467 | 20/18723 | 4.55e-05 | 8.35e-04 | 12 |
| Page: 1 2 3 4 5 6 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa009005 | Esophagus | ESCC | Terpenoid backbone biosynthesis | 20/4205 | 23/8465 | 2.14e-04 | 7.87e-04 | 4.03e-04 | 20 |
| hsa0090012 | Esophagus | ESCC | Terpenoid backbone biosynthesis | 20/4205 | 23/8465 | 2.14e-04 | 7.87e-04 | 4.03e-04 | 20 |
| hsa00900 | Liver | HCC | Terpenoid backbone biosynthesis | 17/4020 | 23/8465 | 9.26e-03 | 2.46e-02 | 1.37e-02 | 17 |
| hsa009001 | Liver | HCC | Terpenoid backbone biosynthesis | 17/4020 | 23/8465 | 9.26e-03 | 2.46e-02 | 1.37e-02 | 17 |
| hsa009004 | Oral cavity | OSCC | Terpenoid backbone biosynthesis | 19/3704 | 23/8465 | 1.55e-04 | 5.34e-04 | 2.72e-04 | 19 |
| hsa0090011 | Oral cavity | OSCC | Terpenoid backbone biosynthesis | 19/3704 | 23/8465 | 1.55e-04 | 5.34e-04 | 2.72e-04 | 19 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| RCE1 | SNV | Missense_Mutation | rs367622666 | c.656G>A | p.Arg219His | p.R219H | Q9Y256 | protein_coding | tolerated(0.19) | benign(0.009) | TCGA-C8-A1HG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| RCE1 | SNV | Missense_Mutation | rs201699815 | c.845N>A | p.Arg282Gln | p.R282Q | Q9Y256 | protein_coding | tolerated(0.3) | benign(0.019) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| RCE1 | SNV | Missense_Mutation | rs746725023 | c.844N>T | p.Arg282Trp | p.R282W | Q9Y256 | protein_coding | tolerated(0.19) | benign(0) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| RCE1 | SNV | Missense_Mutation | c.749G>A | p.Arg250His | p.R250H | Q9Y256 | protein_coding | deleterious(0) | possibly_damaging(0.78) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| RCE1 | SNV | Missense_Mutation | c.946N>A | p.Leu316Ile | p.L316I | Q9Y256 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.981) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| RCE1 | SNV | Missense_Mutation | novel | c.736N>G | p.Phe246Val | p.F246V | Q9Y256 | protein_coding | deleterious(0.01) | benign(0.092) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| RCE1 | SNV | Missense_Mutation | novel | c.373N>G | p.Ile125Val | p.I125V | Q9Y256 | protein_coding | tolerated(1) | benign(0.003) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| RCE1 | SNV | Missense_Mutation | novel | c.724G>A | p.Ala242Thr | p.A242T | Q9Y256 | protein_coding | deleterious(0.04) | possibly_damaging(0.723) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| RCE1 | SNV | Missense_Mutation | novel | c.955N>T | p.Arg319Trp | p.R319W | Q9Y256 | protein_coding | deleterious_low_confidence(0.01) | benign(0.248) | TCGA-AX-A1C5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | SD |
| RCE1 | SNV | Missense_Mutation | novel | c.602N>T | p.Pro201Leu | p.P201L | Q9Y256 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 9986 | RCE1 | ENZYME, PROTEASE, DRUGGABLE GENOME | NSC-37136 | CHEMBL1370674 | ||
| 9986 | RCE1 | ENZYME, PROTEASE, DRUGGABLE GENOME | inhibitor | 252166757 | ||
| 9986 | RCE1 | ENZYME, PROTEASE, DRUGGABLE GENOME | FLUNARIZINE DIHYDROCHLORIDE | FLUNARIZINE DIHYDROCHLORIDE | ||
| 9986 | RCE1 | ENZYME, PROTEASE, DRUGGABLE GENOME | HTS-9915 | CHEMBL512935 | ||
| 9986 | RCE1 | ENZYME, PROTEASE, DRUGGABLE GENOME | SJ000293754 | CHEMBL486706 | ||
| 9986 | RCE1 | ENZYME, PROTEASE, DRUGGABLE GENOME | LEVOFLOXACIN | LEVOFLOXACIN | ||
| 9986 | RCE1 | ENZYME, PROTEASE, DRUGGABLE GENOME | inhibitor | 252166780 | ||
| 9986 | RCE1 | ENZYME, PROTEASE, DRUGGABLE GENOME | ACRIDIN-1-YLAMINE | CHEMBL146525 | ||
| 9986 | RCE1 | ENZYME, PROTEASE, DRUGGABLE GENOME | GNF-PF-763 | CHEMBL1576338 |
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