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Gene: RCBTB2 |
Gene summary for RCBTB2 |
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Gene information | Species | Human | Gene symbol | RCBTB2 | Gene ID | 1102 |
Gene name | RCC1 and BTB domain containing protein 2 | |
Gene Alias | CHC1L | |
Cytomap | 13q14.2 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | O95199 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1102 | RCBTB2 | LZE8T | Human | Esophagus | ESCC | 1.33e-02 | 4.88e-02 | 0.067 |
1102 | RCBTB2 | P2T-E | Human | Esophagus | ESCC | 6.91e-12 | 1.14e-01 | 0.1177 |
1102 | RCBTB2 | P5T-E | Human | Esophagus | ESCC | 1.56e-03 | -2.11e-02 | 0.1327 |
1102 | RCBTB2 | P8T-E | Human | Esophagus | ESCC | 3.16e-10 | 1.85e-01 | 0.0889 |
1102 | RCBTB2 | P9T-E | Human | Esophagus | ESCC | 1.13e-06 | 7.16e-02 | 0.1131 |
1102 | RCBTB2 | P10T-E | Human | Esophagus | ESCC | 6.91e-08 | 1.17e-01 | 0.116 |
1102 | RCBTB2 | P12T-E | Human | Esophagus | ESCC | 1.15e-04 | 5.25e-02 | 0.1122 |
1102 | RCBTB2 | P17T-E | Human | Esophagus | ESCC | 2.80e-02 | 2.15e-01 | 0.1278 |
1102 | RCBTB2 | P20T-E | Human | Esophagus | ESCC | 5.09e-06 | 2.74e-01 | 0.1124 |
1102 | RCBTB2 | P23T-E | Human | Esophagus | ESCC | 3.21e-08 | 2.26e-01 | 0.108 |
1102 | RCBTB2 | P24T-E | Human | Esophagus | ESCC | 8.75e-07 | 9.15e-02 | 0.1287 |
1102 | RCBTB2 | P27T-E | Human | Esophagus | ESCC | 1.15e-07 | 8.91e-02 | 0.1055 |
1102 | RCBTB2 | P28T-E | Human | Esophagus | ESCC | 3.99e-02 | 3.20e-02 | 0.1149 |
1102 | RCBTB2 | P30T-E | Human | Esophagus | ESCC | 2.89e-10 | 3.99e-01 | 0.137 |
1102 | RCBTB2 | P32T-E | Human | Esophagus | ESCC | 4.42e-07 | 5.07e-02 | 0.1666 |
1102 | RCBTB2 | P36T-E | Human | Esophagus | ESCC | 5.59e-03 | 2.45e-01 | 0.1187 |
1102 | RCBTB2 | P37T-E | Human | Esophagus | ESCC | 4.44e-02 | 4.47e-02 | 0.1371 |
1102 | RCBTB2 | P40T-E | Human | Esophagus | ESCC | 7.34e-03 | 3.66e-02 | 0.109 |
1102 | RCBTB2 | P42T-E | Human | Esophagus | ESCC | 3.91e-05 | 1.98e-01 | 0.1175 |
1102 | RCBTB2 | P44T-E | Human | Esophagus | ESCC | 9.43e-06 | 1.64e-01 | 0.1096 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RCBTB2 | SNV | Missense_Mutation | c.259G>A | p.Asp87Asn | p.D87N | protein_coding | tolerated(0.11) | possibly_damaging(0.831) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
RCBTB2 | SNV | Missense_Mutation | c.543N>C | p.Trp181Cys | p.W181C | protein_coding | deleterious(0.04) | probably_damaging(0.957) | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
RCBTB2 | SNV | Missense_Mutation | rs747324839 | c.1277N>T | p.Ser426Leu | p.S426L | protein_coding | deleterious(0) | possibly_damaging(0.7) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RCBTB2 | SNV | Missense_Mutation | novel | c.1084N>C | p.Phe362Leu | p.F362L | protein_coding | tolerated(0.13) | benign(0.217) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RCBTB2 | SNV | Missense_Mutation | novel | c.170N>T | p.Gly57Val | p.G57V | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RCBTB2 | deletion | Frame_Shift_Del | c.118delN | p.Ser40ProfsTer10 | p.S40Pfs*10 | protein_coding | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||||
RCBTB2 | SNV | Missense_Mutation | novel | c.1498N>A | p.Leu500Met | p.L500M | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
RCBTB2 | SNV | Missense_Mutation | c.1235N>G | p.Ala412Gly | p.A412G | protein_coding | deleterious(0) | benign(0.33) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
RCBTB2 | SNV | Missense_Mutation | novel | c.322C>A | p.Leu108Ile | p.L108I | protein_coding | tolerated(0.25) | benign(0.38) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RCBTB2 | SNV | Missense_Mutation | c.1304N>C | p.Ile435Thr | p.I435T | protein_coding | tolerated(0.34) | benign(0.034) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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