Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: RBIS

Gene summary for RBIS

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

RBIS

Gene ID

401466

Gene nameribosomal biogenesis factor
Gene AliasC8orf59
Cytomap8q21.2
Gene Typeprotein-coding
GO ID

GO:0008150

UniProtAcc

A0A024R838


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
401466RBISCA_HPV_1HumanCervixCC8.08e-09-2.53e-010.0264
401466RBISN_HPV_2HumanCervixN_HPV1.49e-021.73e-02-0.0131
401466RBISCCI_1HumanCervixCC1.58e-11-8.02e-010.528
401466RBISCCI_2HumanCervixCC6.52e-06-6.95e-010.5249
401466RBISCCI_3HumanCervixCC1.53e-11-7.45e-010.516
401466RBISCCII_1HumanCervixCC2.57e-25-8.22e-010.3249
401466RBISTumorHumanCervixCC1.06e-53-8.22e-010.1241
401466RBISsample1HumanCervixCC1.81e-02-4.69e-010.0959
401466RBISsample3HumanCervixCC1.25e-03-2.23e-010.1387
401466RBISH2HumanCervixHSIL_HPV1.99e-08-4.13e-010.0632
401466RBISL1HumanCervixCC2.16e-06-2.35e-010.0802
401466RBIST1HumanCervixCC1.30e-04-3.85e-010.0918
401466RBIST3HumanCervixCC3.03e-05-2.58e-010.1389
401466RBISAEH-subject1HumanEndometriumAEH3.02e-193.64e-01-0.3059
401466RBISAEH-subject2HumanEndometriumAEH1.47e-173.87e-01-0.2525
401466RBISAEH-subject3HumanEndometriumAEH1.44e-254.73e-01-0.2576
401466RBISAEH-subject4HumanEndometriumAEH1.18e-143.70e-01-0.2657
401466RBISAEH-subject5HumanEndometriumAEH7.80e-304.57e-01-0.2953
401466RBISEEC-subject1HumanEndometriumEEC2.24e-163.80e-01-0.2682
401466RBISEEC-subject2HumanEndometriumEEC4.35e-173.04e-01-0.2607
Page: 1 2 3 4 5 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:002261310CervixCCribonucleoprotein complex biogenesis88/2311463/187232.11e-053.82e-0488
GO:004225410CervixCCribosome biogenesis62/2311299/187232.48e-054.27e-0462
GO:002261315CervixHSIL_HPVribonucleoprotein complex biogenesis52/737463/187239.85e-126.81e-0952
GO:004225415CervixHSIL_HPVribosome biogenesis40/737299/187231.25e-116.81e-0940
GO:002261325CervixN_HPVribonucleoprotein complex biogenesis30/534463/187232.78e-057.49e-0430
GO:004225424CervixN_HPVribosome biogenesis21/534299/187231.46e-042.68e-0321
GO:002261316EndometriumAEHribonucleoprotein complex biogenesis107/2100463/187231.43e-134.08e-11107
GO:004225416EndometriumAEHribosome biogenesis67/2100299/187231.95e-081.18e-0667
GO:002261317EndometriumEECribonucleoprotein complex biogenesis108/2168463/187234.60e-139.86e-11108
GO:004225417EndometriumEECribosome biogenesis68/2168299/187232.90e-081.68e-0668
GO:002261327EsophagusHGINribonucleoprotein complex biogenesis158/2587463/187232.61e-295.23e-26158
GO:004225426EsophagusHGINribosome biogenesis101/2587299/187238.74e-194.03e-16101
GO:0022613111EsophagusESCCribonucleoprotein complex biogenesis365/8552463/187231.74e-491.11e-45365
GO:0042254111EsophagusESCCribosome biogenesis252/8552299/187233.27e-441.04e-40252
GO:00226138LungAISribonucleoprotein complex biogenesis63/1849463/187235.49e-034.68e-0263
GO:002261318ProstateBPHribonucleoprotein complex biogenesis150/3107463/187232.18e-175.62e-15150
GO:004225418ProstateBPHribosome biogenesis90/3107299/187233.82e-091.44e-0790
GO:002261319ProstateTumorribonucleoprotein complex biogenesis159/3246463/187233.17e-191.52e-16159
GO:004225419ProstateTumorribosome biogenesis96/3246299/187232.76e-101.51e-0896
GO:002261328SkinAKribonucleoprotein complex biogenesis108/1910463/187238.48e-176.27e-14108
Page: 1 2 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
Page: 1 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1