![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: RBFA |
Gene summary for RBFA |
![]() |
Gene information | Species | Human | Gene symbol | RBFA | Gene ID | 79863 |
Gene name | ribosome binding factor A | |
Gene Alias | C18orf22 | |
Cytomap | 18q23 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8N0V3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79863 | RBFA | LZE4T | Human | Esophagus | ESCC | 9.52e-09 | 2.16e-01 | 0.0811 |
79863 | RBFA | LZE7T | Human | Esophagus | ESCC | 7.13e-11 | 4.90e-01 | 0.0667 |
79863 | RBFA | LZE24T | Human | Esophagus | ESCC | 1.63e-08 | 2.84e-01 | 0.0596 |
79863 | RBFA | LZE21T | Human | Esophagus | ESCC | 1.06e-04 | 1.52e-01 | 0.0655 |
79863 | RBFA | P1T-E | Human | Esophagus | ESCC | 8.29e-09 | 6.09e-01 | 0.0875 |
79863 | RBFA | P2T-E | Human | Esophagus | ESCC | 5.96e-19 | 3.33e-01 | 0.1177 |
79863 | RBFA | P4T-E | Human | Esophagus | ESCC | 7.91e-29 | 6.04e-01 | 0.1323 |
79863 | RBFA | P5T-E | Human | Esophagus | ESCC | 7.01e-14 | 3.21e-01 | 0.1327 |
79863 | RBFA | P8T-E | Human | Esophagus | ESCC | 1.19e-13 | 1.80e-01 | 0.0889 |
79863 | RBFA | P9T-E | Human | Esophagus | ESCC | 3.30e-16 | 3.06e-01 | 0.1131 |
79863 | RBFA | P10T-E | Human | Esophagus | ESCC | 3.22e-16 | 2.68e-01 | 0.116 |
79863 | RBFA | P11T-E | Human | Esophagus | ESCC | 2.56e-09 | 3.14e-01 | 0.1426 |
79863 | RBFA | P12T-E | Human | Esophagus | ESCC | 3.33e-23 | 3.22e-01 | 0.1122 |
79863 | RBFA | P15T-E | Human | Esophagus | ESCC | 3.64e-09 | 1.88e-01 | 0.1149 |
79863 | RBFA | P16T-E | Human | Esophagus | ESCC | 4.40e-25 | 2.19e-01 | 0.1153 |
79863 | RBFA | P19T-E | Human | Esophagus | ESCC | 2.41e-02 | 3.04e-01 | 0.1662 |
79863 | RBFA | P20T-E | Human | Esophagus | ESCC | 2.27e-22 | 5.02e-01 | 0.1124 |
79863 | RBFA | P21T-E | Human | Esophagus | ESCC | 2.92e-44 | 6.95e-01 | 0.1617 |
79863 | RBFA | P22T-E | Human | Esophagus | ESCC | 6.44e-27 | 4.41e-01 | 0.1236 |
79863 | RBFA | P23T-E | Human | Esophagus | ESCC | 1.63e-24 | 4.86e-01 | 0.108 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
GO:004225412 | Liver | Cirrhotic | ribosome biogenesis | 154/4634 | 299/18723 | 1.18e-23 | 6.72e-21 | 154 |
GO:000636412 | Liver | Cirrhotic | rRNA processing | 115/4634 | 225/18723 | 1.12e-17 | 1.64e-15 | 115 |
GO:00160724 | Liver | Cirrhotic | rRNA metabolic process | 119/4634 | 236/18723 | 1.19e-17 | 1.70e-15 | 119 |
GO:00344701 | Liver | Cirrhotic | ncRNA processing | 158/4634 | 395/18723 | 1.09e-11 | 6.96e-10 | 158 |
GO:00346603 | Liver | Cirrhotic | ncRNA metabolic process | 173/4634 | 485/18723 | 3.64e-08 | 1.21e-06 | 173 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RBFA | insertion | Frame_Shift_Ins | novel | c.351_352insCGCACTCCAATGGTGAGCGTGGCTCCCACCATCCATTTGCT | p.Tyr118ArgfsTer26 | p.Y118Rfs*26 | Q8N0V3 | protein_coding | TCGA-A7-A0CD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
RBFA | insertion | Frame_Shift_Ins | novel | c.563_564insA | p.Ala189SerfsTer4 | p.A189Sfs*4 | Q8N0V3 | protein_coding | TCGA-A8-A083-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
RBFA | insertion | Nonsense_Mutation | novel | c.565_566insTGTAGTGGCACTATCTTGGCTCACTGCAAGTTCCGC | p.Ala189delinsValTerTrpHisTyrLeuGlySerLeuGlnValProPro | p.A189delinsV*WHYLGSLQVPP | Q8N0V3 | protein_coding | TCGA-A8-A083-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
RBFA | insertion | Frame_Shift_Ins | novel | c.356_357insTAAAGTTACTCTTTTTGCCC | p.Leu120LysfsTer17 | p.L120Kfs*17 | Q8N0V3 | protein_coding | TCGA-BH-A0BV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | ||
RBFA | deletion | Frame_Shift_Del | novel | c.921delN | p.Val308LeufsTer61 | p.V308Lfs*61 | Q8N0V3 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
RBFA | SNV | Missense_Mutation | novel | c.313N>G | p.Thr105Ala | p.T105A | Q8N0V3 | protein_coding | tolerated(0.22) | benign(0.084) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RBFA | deletion | Frame_Shift_Del | c.754delN | p.Arg253GlyfsTer19 | p.R253Gfs*19 | Q8N0V3 | protein_coding | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |||
RBFA | SNV | Missense_Mutation | novel | c.348N>T | p.Glu116Asp | p.E116D | Q8N0V3 | protein_coding | tolerated(0.09) | benign(0.255) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RBFA | SNV | Missense_Mutation | novel | c.750G>T | p.Glu250Asp | p.E250D | Q8N0V3 | protein_coding | tolerated(0.32) | benign(0.094) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RBFA | SNV | Missense_Mutation | rs749018708 | c.950C>T | p.Ala317Val | p.A317V | Q8N0V3 | protein_coding | deleterious(0.04) | benign(0.017) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |