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Gene: RBAK-RBAKDN |
Gene summary for RBAK-RBAKDN |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | RBAK-RBAKDN | Gene ID | 100533952 |
| Gene name | RBAK-RBAKDN readthrough | |
| Gene Alias | RBAK | |
| Cytomap | 7p22.1 | |
| Gene Type | protein-coding | GO ID | NA | UniProtAcc | A0A0A6YYG8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 100533952 | RBAK-RBAKDN | C21 | Human | Oral cavity | OSCC | 2.53e-07 | 3.26e-01 | 0.2678 |
| 100533952 | RBAK-RBAKDN | C30 | Human | Oral cavity | OSCC | 1.36e-13 | 5.84e-01 | 0.3055 |
| 100533952 | RBAK-RBAKDN | C06 | Human | Oral cavity | OSCC | 1.48e-03 | 5.26e-01 | 0.2699 |
| 100533952 | RBAK-RBAKDN | C08 | Human | Oral cavity | OSCC | 2.97e-07 | 2.07e-01 | 0.1919 |
| 100533952 | RBAK-RBAKDN | LP15 | Human | Oral cavity | LP | 9.65e-04 | 5.47e-01 | 0.2174 |
| 100533952 | RBAK-RBAKDN | PTC04 | Human | Thyroid | PTC | 5.43e-04 | 8.56e-02 | 0.1927 |
| 100533952 | RBAK-RBAKDN | PTC05 | Human | Thyroid | PTC | 4.70e-03 | 1.66e-01 | 0.2065 |
| 100533952 | RBAK-RBAKDN | PTC06 | Human | Thyroid | PTC | 6.68e-06 | 1.67e-01 | 0.2057 |
| 100533952 | RBAK-RBAKDN | PTC07 | Human | Thyroid | PTC | 5.85e-06 | 1.51e-01 | 0.2044 |
| 100533952 | RBAK-RBAKDN | ATC12 | Human | Thyroid | ATC | 1.65e-23 | 4.03e-01 | 0.34 |
| 100533952 | RBAK-RBAKDN | ATC13 | Human | Thyroid | ATC | 2.11e-25 | 4.68e-01 | 0.34 |
| 100533952 | RBAK-RBAKDN | ATC2 | Human | Thyroid | ATC | 5.35e-04 | 3.31e-01 | 0.34 |
| 100533952 | RBAK-RBAKDN | ATC3 | Human | Thyroid | ATC | 6.30e-07 | 4.23e-01 | 0.338 |
| 100533952 | RBAK-RBAKDN | ATC4 | Human | Thyroid | ATC | 1.30e-27 | 5.05e-01 | 0.34 |
| 100533952 | RBAK-RBAKDN | ATC5 | Human | Thyroid | ATC | 1.04e-27 | 5.06e-01 | 0.34 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| RBAK-RBAKDN | SNV | Missense_Mutation | novel | c.242N>T | p.Ala81Val | p.A81V | protein_coding | tolerated(0.3) | benign(0) | TCGA-D5-6539-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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