GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007155925 | Thyroid | ATC | response to transforming growth factor beta | 142/6293 | 256/18723 | 4.30e-13 | 1.94e-11 | 142 |
GO:007156026 | Thyroid | ATC | cellular response to transforming growth factor beta stimulus | 137/6293 | 250/18723 | 3.69e-12 | 1.49e-10 | 137 |
GO:000717924 | Thyroid | ATC | transforming growth factor beta receptor signaling pathway | 112/6293 | 198/18723 | 2.42e-11 | 8.44e-10 | 112 |
GO:000717823 | Thyroid | ATC | transmembrane receptor protein serine/threonine kinase signaling pathway | 170/6293 | 355/18723 | 1.40e-08 | 2.87e-07 | 170 |
GO:001701522 | Thyroid | ATC | regulation of transforming growth factor beta receptor signaling pathway | 74/6293 | 128/18723 | 1.58e-08 | 3.20e-07 | 74 |
GO:190384422 | Thyroid | ATC | regulation of cellular response to transforming growth factor beta stimulus | 75/6293 | 131/18723 | 2.26e-08 | 4.39e-07 | 75 |
GO:009028721 | Thyroid | ATC | regulation of cellular response to growth factor stimulus | 140/6293 | 304/18723 | 3.91e-06 | 4.33e-05 | 140 |
GO:009009214 | Thyroid | ATC | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 120/6293 | 256/18723 | 6.62e-06 | 6.85e-05 | 120 |
GO:003051212 | Thyroid | ATC | negative regulation of transforming growth factor beta receptor signaling pathway | 43/6293 | 81/18723 | 2.33e-04 | 1.50e-03 | 43 |
GO:009010111 | Thyroid | ATC | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 62/6293 | 131/18723 | 7.59e-04 | 4.20e-03 | 62 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RASL11B | SNV | Missense_Mutation | | c.481C>G | p.Gln161Glu | p.Q161E | Q9BPW5 | protein_coding | tolerated(0.19) | benign(0.005) | TCGA-A7-A0CE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
RASL11B | SNV | Missense_Mutation | | c.178N>A | p.Gly60Ser | p.G60S | Q9BPW5 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-BH-A18H-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
RASL11B | insertion | Frame_Shift_Ins | novel | c.543_544insGAACC | p.Ser182GlufsTer51 | p.S182Efs*51 | Q9BPW5 | protein_coding | | | TCGA-A8-A09T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
RASL11B | insertion | In_Frame_Ins | novel | c.544_545insACTTGG | p.Ser182delinsTyrLeuAla | p.S182delinsYLA | Q9BPW5 | protein_coding | | | TCGA-A8-A09T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
RASL11B | insertion | Frame_Shift_Ins | novel | c.671_672insGCTCT | p.Pro225LeufsTer8 | p.P225Lfs*8 | Q9BPW5 | protein_coding | | | TCGA-A8-A09T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
RASL11B | insertion | Nonsense_Mutation | novel | c.672_673insTAGACAAAAGCGCCATGCTAGGGTTTTTCCC | p.Pro225Ter | p.P225* | Q9BPW5 | protein_coding | | | TCGA-A8-A09T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
RASL11B | insertion | Frame_Shift_Ins | novel | c.730_731insGCTGCACTGTTATTTATTCCCACTCTGTGCAG | p.Thr244SerfsTer37 | p.T244Sfs*37 | Q9BPW5 | protein_coding | | | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RASL11B | insertion | In_Frame_Ins | novel | c.640_641insTTAGCCCTGGGTCTGGTCTTGGACGACCCCTGACGG | p.Arg214delinsLeuSerProGlySerGlyLeuGlyArgProLeuThrGly | p.R214delinsLSPGSGLGRPLTG | Q9BPW5 | protein_coding | | | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
RASL11B | SNV | Missense_Mutation | | c.644N>A | p.Arg215Lys | p.R215K | Q9BPW5 | protein_coding | tolerated(0.11) | benign(0.003) | TCGA-AA-A01C-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
RASL11B | SNV | Missense_Mutation | novel | c.314N>C | p.Asn105Thr | p.N105T | Q9BPW5 | protein_coding | tolerated(0.24) | benign(0.013) | TCGA-G4-6297-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | PD |