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Gene: RANBP10 |
Gene summary for RANBP10 |
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Gene information | Species | Human | Gene symbol | RANBP10 | Gene ID | 57610 |
Gene name | RAN binding protein 10 | |
Gene Alias | RANBP10 | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q6VN20 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57610 | RANBP10 | AEH-subject5 | Human | Endometrium | AEH | 4.27e-02 | 1.82e-01 | -0.2953 |
57610 | RANBP10 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 2.84e-03 | 5.16e-02 | -0.1875 |
57610 | RANBP10 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.02e-02 | 6.09e-02 | -0.1883 |
57610 | RANBP10 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.19e-03 | 1.12e-02 | -0.1917 |
57610 | RANBP10 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 1.97e-04 | 2.35e-01 | -0.1269 |
57610 | RANBP10 | NAFLD1 | Human | Liver | NAFLD | 2.64e-07 | 6.54e-01 | -0.04 |
57610 | RANBP10 | HCC1_Meng | Human | Liver | HCC | 2.06e-05 | -1.38e-01 | 0.0246 |
57610 | RANBP10 | HCC2 | Human | Liver | HCC | 2.47e-04 | 2.26e+00 | 0.5341 |
57610 | RANBP10 | S028 | Human | Liver | HCC | 2.05e-04 | 3.75e-01 | 0.2503 |
57610 | RANBP10 | S029 | Human | Liver | HCC | 2.25e-02 | 2.96e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Endometrium | ![]() | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer | ||
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RANBP10 | SNV | Missense_Mutation | rs189620738 | c.319N>A | p.Val107Met | p.V107M | Q6VN20 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RANBP10 | insertion | Nonsense_Mutation | novel | c.983_984insGTTAAGATGGCCAAATAATACATTTACTCTAAATTGATTGCC | p.Leu329_Phe330insArgTrpProAsnAsnThrPheThrLeuAsnTerLeuProLeu | p.L329_F330insRWPNNTFTLN*LPL | Q6VN20 | protein_coding | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RANBP10 | insertion | Nonsense_Mutation | novel | c.1426_1427insTTCTTTGAGGGCAGTGTGCAGTCTGGGTGCCCT | p.Asn476delinsIleLeuTerGlyGlnCysAlaValTrpValProTyr | p.N476delinsIL*GQCAVWVPY | Q6VN20 | protein_coding | TCGA-AO-A0J5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Other, specify in notesBisphosphonate | zoledronic | PD | ||
RANBP10 | SNV | Missense_Mutation | novel | c.1530G>T | p.Arg510Ser | p.R510S | Q6VN20 | protein_coding | deleterious(0.01) | probably_damaging(0.95) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RANBP10 | SNV | Missense_Mutation | rs751756862 | c.1061G>A | p.Arg354Gln | p.R354Q | Q6VN20 | protein_coding | tolerated(0.06) | benign(0.206) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RANBP10 | SNV | Missense_Mutation | c.1072N>A | p.Ser358Thr | p.S358T | Q6VN20 | protein_coding | tolerated(0.16) | possibly_damaging(0.88) | TCGA-EK-A2R9-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
RANBP10 | SNV | Missense_Mutation | c.373C>G | p.Gln125Glu | p.Q125E | Q6VN20 | protein_coding | tolerated(0.06) | benign(0.081) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
RANBP10 | SNV | Missense_Mutation | rs764159885 | c.746G>A | p.Arg249Gln | p.R249Q | Q6VN20 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD |
RANBP10 | SNV | Missense_Mutation | novel | c.1640N>T | p.Ala547Val | p.A547V | Q6VN20 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RANBP10 | SNV | Missense_Mutation | rs758630219 | c.1177N>A | p.Val393Ile | p.V393I | Q6VN20 | protein_coding | tolerated(0.57) | benign(0.007) | TCGA-AA-3854-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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