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Gene: RAE1 |
Gene summary for RAE1 |
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Gene information | Species | Human | Gene symbol | RAE1 | Gene ID | 8480 |
Gene name | ribonucleic acid export 1 | |
Gene Alias | Gle2 | |
Cytomap | 20q13.31 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | P78406 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8480 | RAE1 | LZE2T | Human | Esophagus | ESCC | 5.77e-05 | 6.50e-01 | 0.082 |
8480 | RAE1 | LZE4T | Human | Esophagus | ESCC | 5.68e-21 | 5.66e-01 | 0.0811 |
8480 | RAE1 | LZE7T | Human | Esophagus | ESCC | 1.10e-06 | 5.73e-01 | 0.0667 |
8480 | RAE1 | LZE8T | Human | Esophagus | ESCC | 5.42e-04 | 1.89e-01 | 0.067 |
8480 | RAE1 | LZE20T | Human | Esophagus | ESCC | 2.08e-12 | 4.13e-01 | 0.0662 |
8480 | RAE1 | LZE22T | Human | Esophagus | ESCC | 1.01e-02 | 2.76e-01 | 0.068 |
8480 | RAE1 | LZE24T | Human | Esophagus | ESCC | 5.60e-15 | 3.52e-01 | 0.0596 |
8480 | RAE1 | LZE21T | Human | Esophagus | ESCC | 8.80e-04 | 2.79e-01 | 0.0655 |
8480 | RAE1 | LZE6T | Human | Esophagus | ESCC | 4.17e-02 | 2.68e-01 | 0.0845 |
8480 | RAE1 | P1T-E | Human | Esophagus | ESCC | 3.04e-15 | 5.42e-01 | 0.0875 |
8480 | RAE1 | P2T-E | Human | Esophagus | ESCC | 2.95e-49 | 7.53e-01 | 0.1177 |
8480 | RAE1 | P4T-E | Human | Esophagus | ESCC | 1.48e-22 | 5.23e-01 | 0.1323 |
8480 | RAE1 | P5T-E | Human | Esophagus | ESCC | 2.48e-26 | 4.51e-01 | 0.1327 |
8480 | RAE1 | P8T-E | Human | Esophagus | ESCC | 4.70e-21 | 3.80e-01 | 0.0889 |
8480 | RAE1 | P9T-E | Human | Esophagus | ESCC | 2.40e-13 | 2.98e-01 | 0.1131 |
8480 | RAE1 | P10T-E | Human | Esophagus | ESCC | 2.76e-60 | 9.80e-01 | 0.116 |
8480 | RAE1 | P11T-E | Human | Esophagus | ESCC | 5.18e-17 | 7.60e-01 | 0.1426 |
8480 | RAE1 | P12T-E | Human | Esophagus | ESCC | 2.00e-59 | 1.11e+00 | 0.1122 |
8480 | RAE1 | P15T-E | Human | Esophagus | ESCC | 1.69e-44 | 9.39e-01 | 0.1149 |
8480 | RAE1 | P16T-E | Human | Esophagus | ESCC | 7.25e-62 | 1.09e+00 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0006403110 | Esophagus | ESCC | RNA localization | 166/8552 | 201/18723 | 1.95e-27 | 6.18e-25 | 166 |
GO:005123617 | Esophagus | ESCC | establishment of RNA localization | 134/8552 | 166/18723 | 1.23e-20 | 1.81e-18 | 134 |
GO:0051168110 | Esophagus | ESCC | nuclear export | 126/8552 | 154/18723 | 1.88e-20 | 2.65e-18 | 126 |
GO:005102815 | Esophagus | ESCC | mRNA transport | 110/8552 | 130/18723 | 2.76e-20 | 3.80e-18 | 110 |
GO:005065717 | Esophagus | ESCC | nucleic acid transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:005065817 | Esophagus | ESCC | RNA transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:001593117 | Esophagus | ESCC | nucleobase-containing compound transport | 162/8552 | 222/18723 | 9.87e-17 | 7.93e-15 | 162 |
GO:190285015 | Esophagus | ESCC | microtubule cytoskeleton organization involved in mitosis | 116/8552 | 147/18723 | 1.25e-16 | 9.91e-15 | 116 |
GO:000705214 | Esophagus | ESCC | mitotic spindle organization | 97/8552 | 120/18723 | 2.17e-15 | 1.33e-13 | 97 |
GO:000705114 | Esophagus | ESCC | spindle organization | 134/8552 | 184/18723 | 5.70e-14 | 2.87e-12 | 134 |
GO:007116612 | Esophagus | ESCC | ribonucleoprotein complex localization | 66/8552 | 77/18723 | 2.94e-13 | 1.38e-11 | 66 |
GO:007142612 | Esophagus | ESCC | ribonucleoprotein complex export from nucleus | 65/8552 | 76/18723 | 5.56e-13 | 2.50e-11 | 65 |
GO:000640512 | Esophagus | ESCC | RNA export from nucleus | 68/8552 | 84/18723 | 2.99e-11 | 1.01e-09 | 68 |
GO:00064064 | Esophagus | ESCC | mRNA export from nucleus | 51/8552 | 59/18723 | 7.98e-11 | 2.47e-09 | 51 |
GO:00714274 | Esophagus | ESCC | mRNA-containing ribonucleoprotein complex export from nucleus | 51/8552 | 59/18723 | 7.98e-11 | 2.47e-09 | 51 |
GO:003150314 | Esophagus | ESCC | protein-containing complex localization | 139/8552 | 220/18723 | 1.14e-07 | 1.85e-06 | 139 |
GO:00705078 | Esophagus | ESCC | regulation of microtubule cytoskeleton organization | 99/8552 | 148/18723 | 1.43e-07 | 2.29e-06 | 99 |
GO:009022413 | Esophagus | ESCC | regulation of spindle organization | 32/8552 | 39/18723 | 3.27e-06 | 3.65e-05 | 32 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0301321 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0516425 | Esophagus | ESCC | Influenza A | 122/4205 | 171/8465 | 5.01e-09 | 4.79e-08 | 2.45e-08 | 122 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0301331 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0516435 | Esophagus | ESCC | Influenza A | 122/4205 | 171/8465 | 5.01e-09 | 4.79e-08 | 2.45e-08 | 122 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa03013 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa0516421 | Liver | HCC | Influenza A | 101/4020 | 171/8465 | 1.41e-03 | 5.07e-03 | 2.82e-03 | 101 |
hsa0501432 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa030131 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa0516431 | Liver | HCC | Influenza A | 101/4020 | 171/8465 | 1.41e-03 | 5.07e-03 | 2.82e-03 | 101 |
hsa0501428 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa030136 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa0516418 | Oral cavity | OSCC | Influenza A | 116/3704 | 171/8465 | 1.23e-10 | 1.78e-09 | 9.08e-10 | 116 |
hsa05014112 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa0301311 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa0516419 | Oral cavity | OSCC | Influenza A | 116/3704 | 171/8465 | 1.23e-10 | 1.78e-09 | 9.08e-10 | 116 |
hsa0501429 | Oral cavity | LP | Amyotrophic lateral sclerosis | 197/2418 | 364/8465 | 1.25e-25 | 1.39e-23 | 8.93e-24 | 197 |
hsa0516424 | Oral cavity | LP | Influenza A | 80/2418 | 171/8465 | 2.56e-07 | 3.41e-06 | 2.20e-06 | 80 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RAE1 | SNV | Missense_Mutation | c.961N>A | p.Cys321Ser | p.C321S | P78406 | protein_coding | tolerated(0.45) | possibly_damaging(0.72) | TCGA-A2-A0YJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD | |
RAE1 | SNV | Missense_Mutation | c.971N>G | p.Asn324Ser | p.N324S | P78406 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-A8-A06Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RAE1 | SNV | Missense_Mutation | novel | c.782N>A | p.Arg261Gln | p.R261Q | P78406 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RAE1 | SNV | Missense_Mutation | novel | c.1067N>A | p.Arg356His | p.R356H | P78406 | protein_coding | tolerated(1) | benign(0.035) | TCGA-AQ-A04H-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
RAE1 | SNV | Missense_Mutation | rs780225824 | c.370N>A | p.Ala124Thr | p.A124T | P78406 | protein_coding | deleterious(0.01) | possibly_damaging(0.901) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
RAE1 | SNV | Missense_Mutation | rs758243618 | c.199N>T | p.Arg67Cys | p.R67C | P78406 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EA-A439-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
RAE1 | SNV | Missense_Mutation | c.511N>A | p.Glu171Lys | p.E171K | P78406 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-VS-A8QF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
RAE1 | SNV | Missense_Mutation | c.947N>G | p.Gln316Arg | p.Q316R | P78406 | protein_coding | tolerated(0.43) | possibly_damaging(0.698) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RAE1 | SNV | Missense_Mutation | c.854N>G | p.His285Arg | p.H285R | P78406 | protein_coding | deleterious(0.02) | possibly_damaging(0.885) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RAE1 | SNV | Missense_Mutation | c.41N>A | p.Gly14Glu | p.G14E | P78406 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-DM-A1DA-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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