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Gene: RABGGTA |
Gene summary for RABGGTA |
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Gene information | Species | Human | Gene symbol | RABGGTA | Gene ID | 5875 |
Gene name | Rab geranylgeranyltransferase subunit alpha | |
Gene Alias | PTAR3 | |
Cytomap | 14q12 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q92696 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5875 | RABGGTA | LZE4T | Human | Esophagus | ESCC | 1.12e-05 | 2.33e-01 | 0.0811 |
5875 | RABGGTA | LZE7T | Human | Esophagus | ESCC | 4.13e-04 | 2.76e-01 | 0.0667 |
5875 | RABGGTA | LZE8T | Human | Esophagus | ESCC | 1.32e-08 | 2.62e-01 | 0.067 |
5875 | RABGGTA | LZE20T | Human | Esophagus | ESCC | 1.38e-02 | 1.00e-01 | 0.0662 |
5875 | RABGGTA | LZE24T | Human | Esophagus | ESCC | 2.10e-07 | 2.55e-01 | 0.0596 |
5875 | RABGGTA | LZE21T | Human | Esophagus | ESCC | 9.09e-03 | 2.02e-01 | 0.0655 |
5875 | RABGGTA | LZE6T | Human | Esophagus | ESCC | 6.24e-03 | 2.65e-01 | 0.0845 |
5875 | RABGGTA | P1T-E | Human | Esophagus | ESCC | 6.66e-15 | 4.95e-01 | 0.0875 |
5875 | RABGGTA | P2T-E | Human | Esophagus | ESCC | 1.70e-22 | 2.68e-01 | 0.1177 |
5875 | RABGGTA | P4T-E | Human | Esophagus | ESCC | 3.91e-12 | 2.77e-01 | 0.1323 |
5875 | RABGGTA | P5T-E | Human | Esophagus | ESCC | 5.53e-21 | 2.98e-01 | 0.1327 |
5875 | RABGGTA | P8T-E | Human | Esophagus | ESCC | 1.39e-26 | 4.03e-01 | 0.0889 |
5875 | RABGGTA | P9T-E | Human | Esophagus | ESCC | 1.24e-11 | 2.63e-01 | 0.1131 |
5875 | RABGGTA | P10T-E | Human | Esophagus | ESCC | 9.88e-18 | 3.00e-01 | 0.116 |
5875 | RABGGTA | P11T-E | Human | Esophagus | ESCC | 1.44e-15 | 6.52e-01 | 0.1426 |
5875 | RABGGTA | P12T-E | Human | Esophagus | ESCC | 1.21e-32 | 5.46e-01 | 0.1122 |
5875 | RABGGTA | P15T-E | Human | Esophagus | ESCC | 1.60e-17 | 4.64e-01 | 0.1149 |
5875 | RABGGTA | P16T-E | Human | Esophagus | ESCC | 1.81e-13 | 2.22e-01 | 0.1153 |
5875 | RABGGTA | P17T-E | Human | Esophagus | ESCC | 7.00e-09 | 5.70e-01 | 0.1278 |
5875 | RABGGTA | P19T-E | Human | Esophagus | ESCC | 1.21e-05 | 5.23e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RABGGTA | SNV | Missense_Mutation | novel | c.586N>C | p.Asp196His | p.D196H | Q92696 | protein_coding | deleterious(0.03) | benign(0.136) | TCGA-A2-A0YH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
RABGGTA | SNV | Missense_Mutation | c.1309A>C | p.Lys437Gln | p.K437Q | Q92696 | protein_coding | tolerated(0.23) | benign(0.009) | TCGA-AN-A0AR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RABGGTA | SNV | Missense_Mutation | rs377451545 | c.884N>A | p.Arg295Gln | p.R295Q | Q92696 | protein_coding | tolerated(0.32) | benign(0.003) | TCGA-C8-A135-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
RABGGTA | SNV | Missense_Mutation | c.902T>C | p.Leu301Pro | p.L301P | Q92696 | protein_coding | deleterious(0.02) | probably_damaging(0.989) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
RABGGTA | SNV | Missense_Mutation | rs766057450 | c.225N>T | p.Gln75His | p.Q75H | Q92696 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3695-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RABGGTA | SNV | Missense_Mutation | rs369745480 | c.955N>T | p.Arg319Cys | p.R319C | Q92696 | protein_coding | tolerated(0.09) | benign(0.033) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
RABGGTA | SNV | Missense_Mutation | c.46N>A | p.Ala16Thr | p.A16T | Q92696 | protein_coding | tolerated(0.1) | benign(0.163) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
RABGGTA | SNV | Missense_Mutation | rs745370644 | c.1178N>A | p.Arg393Gln | p.R393Q | Q92696 | protein_coding | tolerated(0.07) | possibly_damaging(0.877) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RABGGTA | SNV | Missense_Mutation | novel | c.1079N>C | p.Lys360Thr | p.K360T | Q92696 | protein_coding | tolerated(0.13) | benign(0.123) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RABGGTA | SNV | Missense_Mutation | rs200570806 | c.1010G>A | p.Arg337His | p.R337H | Q92696 | protein_coding | tolerated(0.25) | benign(0) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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