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Gene: RABGAP1 |
Gene summary for RABGAP1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | RABGAP1 | Gene ID | 23637 |
Gene name | RAB GTPase activating protein 1 | |
Gene Alias | GAPCENA | |
Cytomap | 9q33.2-q33.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9Y3P9 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23637 | RABGAP1 | CCI_1 | Human | Cervix | CC | 9.64e-07 | 8.93e-01 | 0.528 |
23637 | RABGAP1 | CCI_2 | Human | Cervix | CC | 5.45e-20 | 1.93e+00 | 0.5249 |
23637 | RABGAP1 | CCI_3 | Human | Cervix | CC | 2.96e-22 | 1.31e+00 | 0.516 |
23637 | RABGAP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.73e-12 | -5.79e-01 | 0.0155 |
23637 | RABGAP1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.60e-04 | -7.79e-01 | 0.0216 |
23637 | RABGAP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.76e-12 | 6.32e-01 | -0.1954 |
23637 | RABGAP1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.21e-05 | 7.77e-01 | -0.2602 |
23637 | RABGAP1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.07e-03 | -3.64e-01 | 0.0674 |
23637 | RABGAP1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.36e-14 | 1.09e+00 | 0.3487 |
23637 | RABGAP1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.33e-10 | 7.45e-01 | 0.281 |
23637 | RABGAP1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.18e-07 | -4.22e-01 | 0.3005 |
23637 | RABGAP1 | F007 | Human | Colorectum | FAP | 6.42e-04 | -3.98e-01 | 0.1176 |
23637 | RABGAP1 | A001-C-207 | Human | Colorectum | FAP | 1.90e-04 | -3.54e-01 | 0.1278 |
23637 | RABGAP1 | A015-C-203 | Human | Colorectum | FAP | 3.39e-35 | -5.69e-01 | -0.1294 |
23637 | RABGAP1 | A015-C-204 | Human | Colorectum | FAP | 1.41e-10 | -5.35e-01 | -0.0228 |
23637 | RABGAP1 | A014-C-040 | Human | Colorectum | FAP | 1.64e-07 | -6.45e-01 | -0.1184 |
23637 | RABGAP1 | A002-C-201 | Human | Colorectum | FAP | 5.07e-25 | -6.29e-01 | 0.0324 |
23637 | RABGAP1 | A002-C-203 | Human | Colorectum | FAP | 1.00e-05 | -2.71e-01 | 0.2786 |
23637 | RABGAP1 | A001-C-119 | Human | Colorectum | FAP | 8.85e-08 | -3.57e-01 | -0.1557 |
23637 | RABGAP1 | A001-C-108 | Human | Colorectum | FAP | 5.75e-17 | -3.39e-01 | -0.0272 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00430877 | Cervix | CC | regulation of GTPase activity | 79/2311 | 348/18723 | 4.21e-08 | 2.60e-06 | 79 |
GO:00435476 | Cervix | CC | positive regulation of GTPase activity | 53/2311 | 255/18723 | 8.72e-05 | 1.16e-03 | 53 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0043547 | Colorectum | AD | positive regulation of GTPase activity | 75/3918 | 255/18723 | 7.95e-04 | 7.91e-03 | 75 |
GO:00430871 | Colorectum | SER | regulation of GTPase activity | 77/2897 | 348/18723 | 5.90e-04 | 8.07e-03 | 77 |
GO:00430872 | Colorectum | MSS | regulation of GTPase activity | 101/3467 | 348/18723 | 1.00e-06 | 3.46e-05 | 101 |
GO:00435471 | Colorectum | MSS | positive regulation of GTPase activity | 68/3467 | 255/18723 | 7.97e-04 | 8.38e-03 | 68 |
GO:00430873 | Colorectum | FAP | regulation of GTPase activity | 85/2622 | 348/18723 | 1.20e-07 | 7.68e-06 | 85 |
GO:00435472 | Colorectum | FAP | positive regulation of GTPase activity | 61/2622 | 255/18723 | 1.39e-05 | 3.73e-04 | 61 |
GO:0090630 | Colorectum | FAP | activation of GTPase activity | 27/2622 | 115/18723 | 4.23e-03 | 2.90e-02 | 27 |
GO:00430874 | Colorectum | CRC | regulation of GTPase activity | 69/2078 | 348/18723 | 1.11e-06 | 6.69e-05 | 69 |
GO:00435473 | Colorectum | CRC | positive regulation of GTPase activity | 49/2078 | 255/18723 | 8.67e-05 | 1.77e-03 | 49 |
GO:00430878 | Endometrium | AEH | regulation of GTPase activity | 66/2100 | 348/18723 | 1.26e-05 | 2.77e-04 | 66 |
GO:00435477 | Endometrium | AEH | positive regulation of GTPase activity | 48/2100 | 255/18723 | 2.18e-04 | 2.67e-03 | 48 |
GO:00906304 | Endometrium | AEH | activation of GTPase activity | 22/2100 | 115/18723 | 8.42e-03 | 4.60e-02 | 22 |
GO:004308712 | Endometrium | EEC | regulation of GTPase activity | 67/2168 | 348/18723 | 1.84e-05 | 3.43e-04 | 67 |
GO:004354712 | Endometrium | EEC | positive regulation of GTPase activity | 50/2168 | 255/18723 | 1.26e-04 | 1.66e-03 | 50 |
GO:009063012 | Endometrium | EEC | activation of GTPase activity | 23/2168 | 115/18723 | 6.04e-03 | 3.57e-02 | 23 |
GO:004308715 | Esophagus | ESCC | regulation of GTPase activity | 183/8552 | 348/18723 | 5.34e-03 | 2.00e-02 | 183 |
GO:00430875 | Liver | NAFLD | regulation of GTPase activity | 62/1882 | 348/18723 | 5.65e-06 | 2.03e-04 | 62 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RABGAP1 | SNV | Missense_Mutation | novel | c.352N>A | p.Glu118Lys | p.E118K | Q9Y3P9 | protein_coding | tolerated(0.71) | benign(0.014) | TCGA-AC-A23G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR |
RABGAP1 | SNV | Missense_Mutation | c.496N>A | p.Glu166Lys | p.E166K | Q9Y3P9 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RABGAP1 | SNV | Missense_Mutation | novel | c.1356N>A | p.Phe452Leu | p.F452L | Q9Y3P9 | protein_coding | deleterious(0.01) | probably_damaging(0.917) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RABGAP1 | SNV | Missense_Mutation | c.1483N>T | p.Arg495Cys | p.R495C | Q9Y3P9 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RABGAP1 | SNV | Missense_Mutation | novel | c.3143N>T | p.Thr1048Met | p.T1048M | Q9Y3P9 | protein_coding | deleterious(0) | possibly_damaging(0.818) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RABGAP1 | SNV | Missense_Mutation | c.560N>T | p.Ser187Leu | p.S187L | Q9Y3P9 | protein_coding | tolerated(0.59) | benign(0.268) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
RABGAP1 | SNV | Missense_Mutation | c.1967N>T | p.Ala656Val | p.A656V | Q9Y3P9 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
RABGAP1 | SNV | Missense_Mutation | c.3018G>T | p.Gln1006His | p.Q1006H | Q9Y3P9 | protein_coding | tolerated(0.07) | benign(0.01) | TCGA-AA-3844-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD | |
RABGAP1 | SNV | Missense_Mutation | novel | c.1231N>A | p.Val411Ile | p.V411I | Q9Y3P9 | protein_coding | deleterious(0.04) | benign(0.134) | TCGA-AA-3851-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RABGAP1 | SNV | Missense_Mutation | c.170A>C | p.Glu57Ala | p.E57A | Q9Y3P9 | protein_coding | tolerated(0.1) | possibly_damaging(0.551) | TCGA-AA-A004-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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