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Gene: RAB4B |
Gene summary for RAB4B |
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Gene information | Species | Human | Gene symbol | RAB4B | Gene ID | 53916 |
Gene name | RAB4B, member RAS oncogene family | |
Gene Alias | RAB4B | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R0K8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
53916 | RAB4B | C04 | Human | Oral cavity | OSCC | 1.67e-06 | 4.64e-01 | 0.2633 |
53916 | RAB4B | C21 | Human | Oral cavity | OSCC | 7.73e-16 | 5.44e-01 | 0.2678 |
53916 | RAB4B | C30 | Human | Oral cavity | OSCC | 1.65e-28 | 1.10e+00 | 0.3055 |
53916 | RAB4B | C38 | Human | Oral cavity | OSCC | 9.20e-05 | 7.77e-01 | 0.172 |
53916 | RAB4B | C43 | Human | Oral cavity | OSCC | 2.16e-14 | 3.90e-01 | 0.1704 |
53916 | RAB4B | C46 | Human | Oral cavity | OSCC | 4.30e-09 | 2.87e-01 | 0.1673 |
53916 | RAB4B | C51 | Human | Oral cavity | OSCC | 1.22e-02 | 3.04e-01 | 0.2674 |
53916 | RAB4B | C57 | Human | Oral cavity | OSCC | 1.88e-08 | 3.59e-01 | 0.1679 |
53916 | RAB4B | C06 | Human | Oral cavity | OSCC | 7.84e-03 | 6.05e-01 | 0.2699 |
53916 | RAB4B | C08 | Human | Oral cavity | OSCC | 2.00e-09 | 3.45e-01 | 0.1919 |
53916 | RAB4B | C09 | Human | Oral cavity | OSCC | 1.06e-08 | 3.37e-01 | 0.1431 |
53916 | RAB4B | LN22 | Human | Oral cavity | OSCC | 5.55e-19 | 2.17e+00 | 0.1733 |
53916 | RAB4B | LP15 | Human | Oral cavity | LP | 2.93e-08 | 1.10e+00 | 0.2174 |
53916 | RAB4B | LP17 | Human | Oral cavity | LP | 7.69e-05 | 4.20e-01 | 0.2349 |
53916 | RAB4B | SYSMH1 | Human | Oral cavity | OSCC | 4.44e-05 | 2.34e-01 | 0.1127 |
53916 | RAB4B | SYSMH2 | Human | Oral cavity | OSCC | 2.25e-02 | 2.40e-01 | 0.2326 |
53916 | RAB4B | SYSMH3 | Human | Oral cavity | OSCC | 3.00e-08 | 2.86e-01 | 0.2442 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00072659 | Oral cavity | OSCC | Ras protein signal transduction | 185/7305 | 337/18723 | 1.95e-09 | 4.60e-08 | 185 |
GO:003010016 | Oral cavity | OSCC | regulation of endocytosis | 121/7305 | 211/18723 | 4.74e-08 | 8.80e-07 | 121 |
GO:003010017 | Oral cavity | LP | regulation of endocytosis | 81/4623 | 211/18723 | 6.57e-06 | 1.29e-04 | 81 |
GO:000726515 | Oral cavity | LP | Ras protein signal transduction | 109/4623 | 337/18723 | 8.44e-04 | 7.36e-03 | 109 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RAB4B | SNV | Missense_Mutation | rs369688842 | c.592N>T | p.Arg198Trp | p.R198W | P61018 | protein_coding | deleterious(0) | possibly_damaging(0.586) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RAB4B | SNV | Missense_Mutation | novel | c.532N>G | p.Leu178Val | p.L178V | P61018 | protein_coding | tolerated(0.15) | benign(0.006) | TCGA-BH-A8FY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RAB4B | SNV | Missense_Mutation | novel | c.614N>T | p.Ala205Val | p.A205V | P61018 | protein_coding | deleterious(0.04) | benign(0) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
RAB4B | SNV | Missense_Mutation | novel | c.562C>G | p.Gln188Glu | p.Q188E | P61018 | protein_coding | deleterious(0.02) | benign(0.009) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RAB4B | SNV | Missense_Mutation | c.480N>T | p.Glu160Asp | p.E160D | P61018 | protein_coding | tolerated(0.25) | benign(0.007) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RAB4B | SNV | Missense_Mutation | c.500N>A | p.Arg167His | p.R167H | P61018 | protein_coding | deleterious(0.04) | benign(0.11) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RAB4B | SNV | Missense_Mutation | c.266N>G | p.Asp89Gly | p.D89G | P61018 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
RAB4B | SNV | Missense_Mutation | rs746085545 | c.211N>T | p.Arg71Trp | p.R71W | P61018 | protein_coding | deleterious(0) | possibly_damaging(0.736) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RAB4B | SNV | Missense_Mutation | c.82N>C | p.Phe28Leu | p.F28L | P61018 | protein_coding | deleterious(0.01) | possibly_damaging(0.63) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RAB4B | SNV | Missense_Mutation | novel | c.149N>C | p.Val50Ala | p.V50A | P61018 | protein_coding | deleterious(0.01) | benign(0.415) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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