Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: RAB35

Gene summary for RAB35

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

RAB35

Gene ID

11021

Gene nameRAB35, member RAS oncogene family
Gene AliasH-ray
Cytomap12q24.23
Gene Typeprotein-coding
GO ID

GO:0000278

UniProtAcc

Q15286


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
11021RAB35LZE4THumanEsophagusESCC9.86e-044.25e-030.0811
11021RAB35LZE8THumanEsophagusESCC1.06e-071.78e-010.067
11021RAB35LZE22THumanEsophagusESCC7.48e-041.74e-010.068
11021RAB35LZE24THumanEsophagusESCC3.34e-132.85e-010.0596
11021RAB35P1T-EHumanEsophagusESCC8.61e-042.27e-010.0875
11021RAB35P2T-EHumanEsophagusESCC9.90e-274.76e-010.1177
11021RAB35P4T-EHumanEsophagusESCC8.46e-152.87e-010.1323
11021RAB35P5T-EHumanEsophagusESCC1.97e-141.08e-010.1327
11021RAB35P8T-EHumanEsophagusESCC2.08e-122.53e-010.0889
11021RAB35P9T-EHumanEsophagusESCC1.72e-083.29e-020.1131
11021RAB35P10T-EHumanEsophagusESCC3.31e-095.81e-020.116
11021RAB35P11T-EHumanEsophagusESCC4.87e-061.87e-010.1426
11021RAB35P12T-EHumanEsophagusESCC1.01e-071.45e-010.1122
11021RAB35P15T-EHumanEsophagusESCC2.14e-131.98e-010.1149
11021RAB35P16T-EHumanEsophagusESCC3.00e-108.65e-020.1153
11021RAB35P17T-EHumanEsophagusESCC4.59e-041.99e-010.1278
11021RAB35P19T-EHumanEsophagusESCC3.71e-107.52e-010.1662
11021RAB35P20T-EHumanEsophagusESCC1.32e-243.64e-010.1124
11021RAB35P21T-EHumanEsophagusESCC3.24e-224.53e-010.1617
11021RAB35P22T-EHumanEsophagusESCC4.57e-141.18e-010.1236
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:001619715EsophagusESCCendosomal transport168/8552230/187232.28e-171.93e-15168
GO:009887615EsophagusESCCvesicle-mediated transport to the plasma membrane99/8552136/187231.13e-103.39e-0999
GO:000028115EsophagusESCCmitotic cytokinesis58/855271/187234.34e-101.15e-0858
GO:000091016EsophagusESCCcytokinesis115/8552173/187232.48e-084.68e-07115
GO:006164015EsophagusESCCcytoskeleton-dependent cytokinesis72/8552100/187238.10e-081.39e-0672
GO:000726510EsophagusESCCRas protein signal transduction201/8552337/187231.44e-072.30e-06201
GO:00324565EsophagusESCCendocytic recycling51/855273/187232.47e-052.10e-0451
GO:199009017EsophagusESCCcellular response to nerve growth factor stimulus38/855253/187231.10e-047.69e-0438
GO:001988225EsophagusESCCantigen processing and presentation67/8552106/187232.03e-041.28e-0367
GO:199008916EsophagusESCCresponse to nerve growth factor39/855256/187232.44e-041.51e-0339
GO:00360106EsophagusESCCprotein localization to endosome18/855224/187233.43e-031.41e-0218
GO:001619711LiverCirrhoticendosomal transport93/4634230/187231.01e-072.93e-0693
GO:009887611LiverCirrhoticvesicle-mediated transport to the plasma membrane59/4634136/187231.46e-062.88e-0559
GO:000726511LiverCirrhoticRas protein signal transduction119/4634337/187238.16e-061.22e-04119
GO:00198827LiverCirrhoticantigen processing and presentation44/4634106/187231.07e-041.10e-0344
GO:00002812LiverCirrhoticmitotic cytokinesis32/463471/187231.48e-041.42e-0332
GO:00009105LiverCirrhoticcytokinesis62/4634173/187237.13e-045.33e-0362
GO:199009011LiverCirrhoticcellular response to nerve growth factor stimulus24/463453/187238.86e-046.37e-0324
GO:199008911LiverCirrhoticresponse to nerve growth factor25/463456/187239.03e-046.46e-0325
GO:00616402LiverCirrhoticcytoskeleton-dependent cytokinesis38/4634100/187232.22e-031.35e-0238
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa04144210EsophagusESCCEndocytosis186/4205251/84659.74e-164.66e-142.39e-14186
hsa0414437EsophagusESCCEndocytosis186/4205251/84659.74e-164.66e-142.39e-14186
hsa0414412LiverCirrhoticEndocytosis119/2530251/84652.33e-094.56e-082.81e-08119
hsa0414413LiverCirrhoticEndocytosis119/2530251/84652.33e-094.56e-082.81e-08119
hsa0414422LiverHCCEndocytosis178/4020251/84652.03e-145.22e-132.91e-13178
hsa0414432LiverHCCEndocytosis178/4020251/84652.03e-145.22e-132.91e-13178
hsa0414427Oral cavityOSCCEndocytosis174/3704251/84659.42e-174.51e-152.29e-15174
hsa04144112Oral cavityOSCCEndocytosis174/3704251/84659.42e-174.51e-152.29e-15174
hsa0414428Oral cavityLPEndocytosis121/2418251/84651.89e-113.70e-102.38e-10121
hsa0414436Oral cavityLPEndocytosis121/2418251/84651.89e-113.70e-102.38e-10121
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
RAB35SNVMissense_Mutationc.416C>Ap.Ala139Aspp.A139DQ15286protein_codingdeleterious(0)probably_damaging(0.989)TCGA-A8-A09X-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
RAB35SNVMissense_Mutationc.135N>Gp.Phe45Leup.F45LQ15286protein_codingdeleterious(0)benign(0.423)TCGA-D8-A1JN-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapyanastrozolumSD
RAB35SNVMissense_Mutationnovelc.393N>Tp.Glu131Aspp.E131DQ15286protein_codingtolerated(0.98)benign(0)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
RAB35SNVMissense_Mutationnovelc.587N>Ap.Arg196Glnp.R196QQ15286protein_codingtolerated(0.48)benign(0.042)TCGA-AA-3984-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
RAB35SNVMissense_Mutationc.206G>Cp.Arg69Prop.R69PQ15286protein_codingdeleterious(0)probably_damaging(1)TCGA-CK-4951-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
RAB35SNVMissense_Mutationc.280N>Ap.Glu94Lysp.E94KQ15286protein_codingtolerated(0.13)benign(0.163)TCGA-CM-5349-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
RAB35SNVMissense_Mutationc.416N>Tp.Ala139Valp.A139VQ15286protein_codingdeleterious(0)possibly_damaging(0.866)TCGA-D5-6540-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
RAB35SNVMissense_Mutationnovelc.517N>Gp.Lys173Glup.K173EQ15286protein_codingtolerated(0.2)benign(0.017)TCGA-AJ-A3EK-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIChemotherapycarboplatinCR
RAB35SNVMissense_Mutationnovelc.469G>Ap.Val157Metp.V157MQ15286protein_codingdeleterious(0)probably_damaging(0.982)TCGA-AX-A2HD-01Endometriumuterine corpus endometrioid carcinomaFemale>=65III/IVUnknownUnknownSD
RAB35SNVMissense_Mutationc.65G>Ap.Ser22Asnp.S22NQ15286protein_codingdeleterious(0)probably_damaging(0.97)TCGA-B5-A0JY-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapydoxorubicinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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