![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: RAB24 |
Gene summary for RAB24 |
![]() |
Gene information | Species | Human | Gene symbol | RAB24 | Gene ID | 53917 |
Gene name | RAB24, member RAS oncogene family | |
Gene Alias | RAB24 | |
Cytomap | 5q35.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q969Q5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
53917 | RAB24 | LZE4T | Human | Esophagus | ESCC | 5.73e-13 | 3.41e-01 | 0.0811 |
53917 | RAB24 | LZE5T | Human | Esophagus | ESCC | 1.57e-02 | 2.39e-01 | 0.0514 |
53917 | RAB24 | LZE7T | Human | Esophagus | ESCC | 3.98e-06 | 2.54e-01 | 0.0667 |
53917 | RAB24 | LZE8T | Human | Esophagus | ESCC | 8.94e-21 | 4.77e-01 | 0.067 |
53917 | RAB24 | LZE20T | Human | Esophagus | ESCC | 4.88e-05 | 2.28e-01 | 0.0662 |
53917 | RAB24 | LZE21D1 | Human | Esophagus | HGIN | 3.53e-05 | 4.13e-01 | 0.0632 |
53917 | RAB24 | LZE22D1 | Human | Esophagus | HGIN | 1.90e-05 | 2.79e-01 | 0.0595 |
53917 | RAB24 | LZE22T | Human | Esophagus | ESCC | 1.57e-03 | 2.10e-01 | 0.068 |
53917 | RAB24 | LZE24T | Human | Esophagus | ESCC | 5.01e-30 | 6.52e-01 | 0.0596 |
53917 | RAB24 | LZE21T | Human | Esophagus | ESCC | 1.97e-09 | 3.96e-01 | 0.0655 |
53917 | RAB24 | LZE6T | Human | Esophagus | ESCC | 9.61e-05 | 2.23e-01 | 0.0845 |
53917 | RAB24 | P1T-E | Human | Esophagus | ESCC | 1.97e-23 | 8.50e-01 | 0.0875 |
53917 | RAB24 | P2T-E | Human | Esophagus | ESCC | 3.95e-50 | 8.75e-01 | 0.1177 |
53917 | RAB24 | P4T-E | Human | Esophagus | ESCC | 1.08e-40 | 7.33e-01 | 0.1323 |
53917 | RAB24 | P5T-E | Human | Esophagus | ESCC | 3.58e-18 | 4.02e-01 | 0.1327 |
53917 | RAB24 | P8T-E | Human | Esophagus | ESCC | 2.33e-07 | 2.13e-01 | 0.0889 |
53917 | RAB24 | P9T-E | Human | Esophagus | ESCC | 1.49e-16 | 3.67e-01 | 0.1131 |
53917 | RAB24 | P10T-E | Human | Esophagus | ESCC | 3.79e-12 | 2.63e-01 | 0.116 |
53917 | RAB24 | P11T-E | Human | Esophagus | ESCC | 2.64e-31 | 8.05e-01 | 0.1426 |
53917 | RAB24 | P12T-E | Human | Esophagus | ESCC | 6.94e-36 | 5.76e-01 | 0.1122 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RAB24 | SNV | Missense_Mutation | rs146377924 | c.605N>G | p.His202Arg | p.H202R | Q969Q5 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.95) | TCGA-A2-A0EN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
RAB24 | SNV | Missense_Mutation | novel | c.213G>T | p.Glu71Asp | p.E71D | Q969Q5 | protein_coding | tolerated(0.17) | benign(0.05) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RAB24 | SNV | Missense_Mutation | c.397C>T | p.Arg133Cys | p.R133C | Q969Q5 | protein_coding | tolerated(0.05) | possibly_damaging(0.671) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
RAB24 | SNV | Missense_Mutation | rs777474622 | c.517N>A | p.Val173Ile | p.V173I | Q969Q5 | protein_coding | tolerated(0.35) | benign(0.019) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RAB24 | SNV | Missense_Mutation | c.193N>A | p.Ala65Thr | p.A65T | Q969Q5 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RAB24 | SNV | Missense_Mutation | novel | c.422A>G | p.Asp141Gly | p.D141G | Q969Q5 | protein_coding | tolerated(0.06) | benign(0.296) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RAB24 | SNV | Missense_Mutation | c.136N>A | p.Val46Met | p.V46M | Q969Q5 | protein_coding | tolerated(0.06) | possibly_damaging(0.84) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RAB24 | SNV | Missense_Mutation | c.164G>A | p.Arg55Gln | p.R55Q | Q969Q5 | protein_coding | tolerated(0.38) | benign(0.007) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
RAB24 | SNV | Missense_Mutation | novel | c.224N>T | p.Arg75Ile | p.R75I | Q969Q5 | protein_coding | deleterious(0.01) | possibly_damaging(0.876) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RAB24 | SNV | Missense_Mutation | novel | c.502G>A | p.Val168Met | p.V168M | Q969Q5 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |