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Gene: RAB20 |
Gene summary for RAB20 |
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Gene information | Species | Human | Gene symbol | RAB20 | Gene ID | 55647 |
Gene name | RAB20, member RAS oncogene family | |
Gene Alias | RAB20 | |
Cytomap | 13q34 | |
Gene Type | protein-coding | GO ID | GO:0001845 | UniProtAcc | Q9NX57 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55647 | RAB20 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.57e-02 | 3.44e-01 | -0.1808 |
55647 | RAB20 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.43e-05 | 3.08e-01 | -0.1954 |
55647 | RAB20 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.83e-06 | 3.61e-01 | -0.1464 |
55647 | RAB20 | HTA11_866_2000001011 | Human | Colorectum | AD | 8.58e-03 | 2.21e-01 | -0.1001 |
55647 | RAB20 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.89e-03 | 4.33e-01 | -0.059 |
55647 | RAB20 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.13e-08 | 3.80e-01 | 0.0674 |
55647 | RAB20 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.41e-04 | 2.88e-01 | 0.294 |
55647 | RAB20 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.29e-17 | 6.79e-01 | 0.3859 |
55647 | RAB20 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 6.03e-13 | 1.34e+00 | 0.2585 |
55647 | RAB20 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.05e-06 | 3.13e-01 | 0.3005 |
55647 | RAB20 | A002-C-205 | Human | Colorectum | FAP | 2.14e-04 | -1.67e-01 | -0.1236 |
55647 | RAB20 | A002-C-114 | Human | Colorectum | FAP | 1.74e-03 | -1.74e-01 | -0.1561 |
55647 | RAB20 | A018-E-020 | Human | Colorectum | FAP | 8.15e-05 | -1.93e-01 | -0.2034 |
55647 | RAB20 | LZE8T | Human | Esophagus | ESCC | 3.85e-02 | 8.95e-02 | 0.067 |
55647 | RAB20 | P2T-E | Human | Esophagus | ESCC | 6.87e-12 | 1.66e-01 | 0.1177 |
55647 | RAB20 | P4T-E | Human | Esophagus | ESCC | 1.19e-08 | 1.98e-01 | 0.1323 |
55647 | RAB20 | P5T-E | Human | Esophagus | ESCC | 1.70e-06 | 6.69e-02 | 0.1327 |
55647 | RAB20 | P8T-E | Human | Esophagus | ESCC | 6.46e-11 | 2.22e-01 | 0.0889 |
55647 | RAB20 | P11T-E | Human | Esophagus | ESCC | 3.56e-03 | 1.79e-01 | 0.1426 |
55647 | RAB20 | P12T-E | Human | Esophagus | ESCC | 1.60e-07 | 2.18e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016050 | Colorectum | AD | vesicle organization | 101/3918 | 300/18723 | 1.65e-07 | 7.17e-06 | 101 |
GO:0030004 | Colorectum | AD | cellular monovalent inorganic cation homeostasis | 36/3918 | 103/18723 | 6.80e-04 | 6.95e-03 | 36 |
GO:0030641 | Colorectum | AD | regulation of cellular pH | 29/3918 | 81/18723 | 1.42e-03 | 1.22e-02 | 29 |
GO:0051453 | Colorectum | AD | regulation of intracellular pH | 26/3918 | 75/18723 | 4.04e-03 | 2.82e-02 | 26 |
GO:0007033 | Colorectum | AD | vacuole organization | 53/3918 | 180/18723 | 4.18e-03 | 2.89e-02 | 53 |
GO:0006885 | Colorectum | AD | regulation of pH | 30/3918 | 91/18723 | 4.95e-03 | 3.32e-02 | 30 |
GO:0055067 | Colorectum | AD | monovalent inorganic cation homeostasis | 45/3918 | 151/18723 | 6.19e-03 | 3.88e-02 | 45 |
GO:0048284 | Colorectum | AD | organelle fusion | 42/3918 | 141/18723 | 8.04e-03 | 4.73e-02 | 42 |
GO:00300041 | Colorectum | SER | cellular monovalent inorganic cation homeostasis | 31/2897 | 103/18723 | 1.31e-04 | 2.66e-03 | 31 |
GO:00160501 | Colorectum | SER | vesicle organization | 69/2897 | 300/18723 | 3.59e-04 | 5.61e-03 | 69 |
GO:00306411 | Colorectum | SER | regulation of cellular pH | 24/2897 | 81/18723 | 9.20e-04 | 1.11e-02 | 24 |
GO:00550671 | Colorectum | SER | monovalent inorganic cation homeostasis | 37/2897 | 151/18723 | 2.48e-03 | 2.33e-02 | 37 |
GO:00514531 | Colorectum | SER | regulation of intracellular pH | 21/2897 | 75/18723 | 3.97e-03 | 3.26e-02 | 21 |
GO:00068851 | Colorectum | SER | regulation of pH | 24/2897 | 91/18723 | 5.03e-03 | 3.88e-02 | 24 |
GO:00160502 | Colorectum | MSS | vesicle organization | 93/3467 | 300/18723 | 1.04e-07 | 4.97e-06 | 93 |
GO:00300042 | Colorectum | MSS | cellular monovalent inorganic cation homeostasis | 31/3467 | 103/18723 | 2.94e-03 | 2.27e-02 | 31 |
GO:00070331 | Colorectum | MSS | vacuole organization | 48/3467 | 180/18723 | 4.32e-03 | 3.07e-02 | 48 |
GO:00482841 | Colorectum | MSS | organelle fusion | 39/3467 | 141/18723 | 4.91e-03 | 3.42e-02 | 39 |
GO:00306412 | Colorectum | MSS | regulation of cellular pH | 25/3467 | 81/18723 | 4.97e-03 | 3.46e-02 | 25 |
GO:00160503 | Colorectum | FAP | vesicle organization | 74/2622 | 300/18723 | 5.16e-07 | 2.66e-05 | 74 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RAB20 | SNV | Missense_Mutation | rs775243830 | c.686N>C | p.Arg229Thr | p.R229T | Q9NX57 | protein_coding | tolerated(0.14) | benign(0.006) | TCGA-A8-A093-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
RAB20 | insertion | Nonsense_Mutation | novel | c.652_653insTCTCAAACCCTTGAACTCAAGCAATC | p.Asp218ValfsTer5 | p.D218Vfs*5 | Q9NX57 | protein_coding | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RAB20 | SNV | Missense_Mutation | c.550G>A | p.Ala184Thr | p.A184T | Q9NX57 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
RAB20 | SNV | Missense_Mutation | c.200N>T | p.Ser67Phe | p.S67F | Q9NX57 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
RAB20 | SNV | Missense_Mutation | c.461N>T | p.Ala154Val | p.A154V | Q9NX57 | protein_coding | deleterious(0.01) | possibly_damaging(0.874) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RAB20 | SNV | Missense_Mutation | rs373875505 | c.223G>A | p.Ala75Thr | p.A75T | Q9NX57 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
RAB20 | SNV | Missense_Mutation | rs753402781 | c.167C>T | p.Thr56Ile | p.T56I | Q9NX57 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
RAB20 | SNV | Missense_Mutation | c.461N>T | p.Ala154Val | p.A154V | Q9NX57 | protein_coding | deleterious(0.01) | possibly_damaging(0.874) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RAB20 | SNV | Missense_Mutation | rs776553635 | c.677A>G | p.Lys226Arg | p.K226R | Q9NX57 | protein_coding | tolerated(0.31) | benign(0.001) | TCGA-AG-3592-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RAB20 | SNV | Missense_Mutation | c.551N>T | p.Ala184Val | p.A184V | Q9NX57 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-G5-6572-02 | Colorectum | NA | NA | NA | NA | NA | NA | NA |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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