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Gene: QTRT1 |
Gene summary for QTRT1 |
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Gene information | Species | Human | Gene symbol | QTRT1 | Gene ID | 81890 |
Gene name | queuine tRNA-ribosyltransferase catalytic subunit 1 | |
Gene Alias | FP3235 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q71RF8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81890 | QTRT1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.81e-13 | 5.11e-01 | -0.0811 |
81890 | QTRT1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.73e-18 | 5.09e-01 | -0.1954 |
81890 | QTRT1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.80e-10 | 4.67e-01 | -0.1207 |
81890 | QTRT1 | HTA11_83_2000001011 | Human | Colorectum | SER | 6.25e-07 | 4.61e-01 | -0.1526 |
81890 | QTRT1 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.24e-20 | 5.33e-01 | -0.1464 |
81890 | QTRT1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.66e-17 | 4.67e-01 | -0.1001 |
81890 | QTRT1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.48e-23 | 7.01e-01 | -0.059 |
81890 | QTRT1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.53e-03 | 3.71e-01 | -0.1706 |
81890 | QTRT1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.75e-02 | 4.06e-01 | -0.1462 |
81890 | QTRT1 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.35e-09 | 5.05e-01 | -0.0842 |
81890 | QTRT1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.02e-30 | 8.45e-01 | 0.096 |
81890 | QTRT1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.08e-10 | 8.45e-01 | 0.0446 |
81890 | QTRT1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 9.41e-09 | 6.34e-01 | 0.0528 |
81890 | QTRT1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.81e-09 | 7.64e-01 | 0.0131 |
81890 | QTRT1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.21e-05 | 5.09e-01 | -0.0177 |
81890 | QTRT1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 7.20e-05 | 6.04e-01 | 0.0171 |
81890 | QTRT1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.05e-19 | 6.60e-01 | 0.0338 |
81890 | QTRT1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.21e-33 | 9.07e-01 | 0.0674 |
81890 | QTRT1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 7.81e-11 | 8.23e-01 | 0.0112 |
81890 | QTRT1 | HTA11_7469_2000001011 | Human | Colorectum | AD | 5.90e-05 | 6.75e-01 | -0.0124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00064002 | Esophagus | ESCC | tRNA modification | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:00344701 | Liver | Cirrhotic | ncRNA processing | 158/4634 | 395/18723 | 1.09e-11 | 6.96e-10 | 158 |
GO:00346603 | Liver | Cirrhotic | ncRNA metabolic process | 173/4634 | 485/18723 | 3.64e-08 | 1.21e-06 | 173 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:0008033 | Liver | HCC | tRNA processing | 87/7958 | 127/18723 | 2.66e-09 | 7.23e-08 | 87 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:0009451 | Liver | HCC | RNA modification | 101/7958 | 167/18723 | 2.02e-06 | 2.78e-05 | 101 |
GO:0006400 | Liver | HCC | tRNA modification | 60/7958 | 90/18723 | 3.09e-06 | 4.09e-05 | 60 |
GO:00344709 | Oral cavity | OSCC | ncRNA processing | 263/7305 | 395/18723 | 4.38e-29 | 2.78e-26 | 263 |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
GO:00080332 | Oral cavity | OSCC | tRNA processing | 78/7305 | 127/18723 | 2.56e-07 | 4.00e-06 | 78 |
GO:00063991 | Oral cavity | OSCC | tRNA metabolic process | 101/7305 | 179/18723 | 1.65e-06 | 2.15e-05 | 101 |
GO:00094511 | Oral cavity | OSCC | RNA modification | 95/7305 | 167/18723 | 2.05e-06 | 2.62e-05 | 95 |
GO:00064001 | Oral cavity | OSCC | tRNA modification | 53/7305 | 90/18723 | 1.04e-04 | 7.70e-04 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
QTRT1 | SNV | Missense_Mutation | c.629N>A | p.Arg210Gln | p.R210Q | Q9BXR0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
QTRT1 | SNV | Missense_Mutation | novel | c.405N>C | p.Glu135Asp | p.E135D | Q9BXR0 | protein_coding | tolerated(0.32) | benign(0.035) | TCGA-DG-A2KM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
QTRT1 | SNV | Missense_Mutation | rs377094295 | c.1081C>T | p.Arg361Cys | p.R361C | Q9BXR0 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
QTRT1 | SNV | Missense_Mutation | novel | c.398N>T | p.Gly133Val | p.G133V | Q9BXR0 | protein_coding | deleterious(0) | benign(0.312) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
QTRT1 | SNV | Missense_Mutation | c.629N>A | p.Arg210Gln | p.R210Q | Q9BXR0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
QTRT1 | SNV | Missense_Mutation | c.319N>A | p.Gly107Ser | p.G107S | Q9BXR0 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
QTRT1 | SNV | Missense_Mutation | novel | c.317G>T | p.Ser106Ile | p.S106I | Q9BXR0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
QTRT1 | SNV | Missense_Mutation | rs747033265 | c.676G>A | p.Ala226Thr | p.A226T | Q9BXR0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
QTRT1 | SNV | Missense_Mutation | c.863N>A | p.Arg288His | p.R288H | Q9BXR0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
QTRT1 | SNV | Missense_Mutation | rs756496433 | c.1021N>A | p.Ala341Thr | p.A341T | Q9BXR0 | protein_coding | deleterious(0.04) | possibly_damaging(0.756) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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