![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: QSOX1 |
Gene summary for QSOX1 |
![]() |
Gene information | Species | Human | Gene symbol | QSOX1 | Gene ID | 5768 |
Gene name | quiescin sulfhydryl oxidase 1 | |
Gene Alias | Q6 | |
Cytomap | 1q25.2 | |
Gene Type | protein-coding | GO ID | GO:0006457 | UniProtAcc | A0A140VKE5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5768 | QSOX1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.56e-10 | 9.68e-01 | -0.1808 |
5768 | QSOX1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.01e-07 | 5.70e-01 | -0.0811 |
5768 | QSOX1 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.56e-17 | 7.50e-01 | -0.1954 |
5768 | QSOX1 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.94e-11 | 2.23e+00 | -0.2602 |
5768 | QSOX1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 7.33e-08 | 1.52e+00 | -0.2196 |
5768 | QSOX1 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.28e-19 | 7.72e-01 | -0.1464 |
5768 | QSOX1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.15e-02 | 3.05e-01 | -0.059 |
5768 | QSOX1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 7.87e-04 | 8.18e-01 | -0.1706 |
5768 | QSOX1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.00e-03 | 6.67e-01 | -0.2061 |
5768 | QSOX1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 6.50e-03 | 4.26e-01 | -0.0179 |
5768 | QSOX1 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.23e-04 | 3.25e-01 | 0.096 |
5768 | QSOX1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.21e-03 | 3.68e-01 | 0.0674 |
5768 | QSOX1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.24e-07 | 4.47e-01 | 0.294 |
5768 | QSOX1 | A015-C-203 | Human | Colorectum | FAP | 2.08e-05 | -1.19e-01 | -0.1294 |
5768 | QSOX1 | A002-C-205 | Human | Colorectum | FAP | 3.37e-05 | -1.49e-01 | -0.1236 |
5768 | QSOX1 | A002-C-114 | Human | Colorectum | FAP | 2.79e-02 | -1.30e-01 | -0.1561 |
5768 | QSOX1 | A015-C-104 | Human | Colorectum | FAP | 3.38e-05 | -1.51e-01 | -0.1899 |
5768 | QSOX1 | A002-C-016 | Human | Colorectum | FAP | 8.14e-06 | -9.67e-02 | 0.0521 |
5768 | QSOX1 | A001-C-203 | Human | Colorectum | FAP | 2.22e-02 | -1.15e-01 | -0.0481 |
5768 | QSOX1 | A002-C-116 | Human | Colorectum | FAP | 7.63e-06 | -1.34e-01 | -0.0452 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009895 | Colorectum | AD | negative regulation of catabolic process | 124/3918 | 320/18723 | 1.66e-13 | 3.35e-11 | 124 |
GO:0031330 | Colorectum | AD | negative regulation of cellular catabolic process | 104/3918 | 262/18723 | 2.66e-12 | 3.96e-10 | 104 |
GO:0010506 | Colorectum | AD | regulation of autophagy | 111/3918 | 317/18723 | 3.57e-09 | 2.35e-07 | 111 |
GO:0016236 | Colorectum | AD | macroautophagy | 103/3918 | 291/18723 | 6.76e-09 | 4.15e-07 | 103 |
GO:0006457 | Colorectum | AD | protein folding | 73/3918 | 212/18723 | 3.24e-06 | 9.10e-05 | 73 |
GO:0016241 | Colorectum | AD | regulation of macroautophagy | 50/3918 | 141/18723 | 4.55e-05 | 7.92e-04 | 50 |
GO:0010507 | Colorectum | AD | negative regulation of autophagy | 31/3918 | 85/18723 | 6.91e-04 | 7.05e-03 | 31 |
GO:00162361 | Colorectum | SER | macroautophagy | 79/2897 | 291/18723 | 1.97e-07 | 1.10e-05 | 79 |
GO:00098951 | Colorectum | SER | negative regulation of catabolic process | 84/2897 | 320/18723 | 3.93e-07 | 2.06e-05 | 84 |
GO:00313301 | Colorectum | SER | negative regulation of cellular catabolic process | 70/2897 | 262/18723 | 1.79e-06 | 7.70e-05 | 70 |
GO:00064571 | Colorectum | SER | protein folding | 54/2897 | 212/18723 | 1.04e-04 | 2.18e-03 | 54 |
GO:00105061 | Colorectum | SER | regulation of autophagy | 74/2897 | 317/18723 | 1.39e-04 | 2.77e-03 | 74 |
GO:00162411 | Colorectum | SER | regulation of macroautophagy | 34/2897 | 141/18723 | 4.74e-03 | 3.72e-02 | 34 |
GO:00313302 | Colorectum | MSS | negative regulation of cellular catabolic process | 96/3467 | 262/18723 | 2.67e-12 | 4.63e-10 | 96 |
GO:00098952 | Colorectum | MSS | negative regulation of catabolic process | 110/3467 | 320/18723 | 7.88e-12 | 1.20e-09 | 110 |
GO:00162362 | Colorectum | MSS | macroautophagy | 93/3467 | 291/18723 | 2.08e-08 | 1.17e-06 | 93 |
GO:00064572 | Colorectum | MSS | protein folding | 71/3467 | 212/18723 | 1.25e-07 | 5.91e-06 | 71 |
GO:00105062 | Colorectum | MSS | regulation of autophagy | 95/3467 | 317/18723 | 4.36e-07 | 1.71e-05 | 95 |
GO:00162412 | Colorectum | MSS | regulation of macroautophagy | 44/3467 | 141/18723 | 1.88e-04 | 2.64e-03 | 44 |
GO:00105071 | Colorectum | MSS | negative regulation of autophagy | 26/3467 | 85/18723 | 4.84e-03 | 3.38e-02 | 26 |
Page: 1 2 3 4 5 6 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
QSOX1 | SNV | Missense_Mutation | c.1714G>C | p.Glu572Gln | p.E572Q | O00391 | protein_coding | tolerated(0.29) | benign(0.255) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
QSOX1 | SNV | Missense_Mutation | c.1275N>G | p.His425Gln | p.H425Q | O00391 | protein_coding | tolerated(0.21) | benign(0.136) | TCGA-A8-A09A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
QSOX1 | SNV | Missense_Mutation | c.847G>A | p.Ala283Thr | p.A283T | O00391 | protein_coding | tolerated(0.41) | benign(0.009) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
QSOX1 | SNV | Missense_Mutation | c.328T>A | p.Cys110Ser | p.C110S | O00391 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E9-A1RE-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
QSOX1 | SNV | Missense_Mutation | novel | c.1864N>T | p.Pro622Ser | p.P622S | O00391 | protein_coding | tolerated(0.17) | benign(0.078) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
QSOX1 | SNV | Missense_Mutation | c.1110C>A | p.Phe370Leu | p.F370L | O00391 | protein_coding | tolerated(0.67) | benign(0) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
QSOX1 | SNV | Missense_Mutation | novel | c.1841N>C | p.Arg614Thr | p.R614T | O00391 | protein_coding | tolerated(0.42) | benign(0.007) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
QSOX1 | SNV | Missense_Mutation | rs747164407 | c.977G>A | p.Arg326His | p.R326H | O00391 | protein_coding | deleterious(0.01) | probably_damaging(0.937) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
QSOX1 | SNV | Missense_Mutation | c.595N>A | p.Leu199Met | p.L199M | O00391 | protein_coding | deleterious(0.01) | possibly_damaging(0.899) | TCGA-4T-AA8H-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
QSOX1 | SNV | Missense_Mutation | c.1574N>G | p.Glu525Gly | p.E525G | O00391 | protein_coding | tolerated(0.88) | benign(0) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |