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Gene: QRSL1 |
Gene summary for QRSL1 |
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Gene information | Species | Human | Gene symbol | QRSL1 | Gene ID | 55278 |
Gene name | glutaminyl-tRNA amidotransferase subunit QRSL1 | |
Gene Alias | COXPD40 | |
Cytomap | 6q21 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | Q9H0R6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55278 | QRSL1 | GSM4909315 | Human | Breast | IDC | 1.29e-23 | 5.95e-01 | 0.21 |
55278 | QRSL1 | GSM4909316 | Human | Breast | IDC | 1.25e-06 | 5.68e-01 | 0.21 |
55278 | QRSL1 | DCIS2 | Human | Breast | DCIS | 2.18e-19 | 6.04e-02 | 0.0085 |
55278 | QRSL1 | LZE4T | Human | Esophagus | ESCC | 2.81e-02 | 7.28e-02 | 0.0811 |
55278 | QRSL1 | LZE8T | Human | Esophagus | ESCC | 2.44e-03 | 1.53e-01 | 0.067 |
55278 | QRSL1 | LZE20T | Human | Esophagus | ESCC | 2.11e-02 | 8.28e-02 | 0.0662 |
55278 | QRSL1 | LZE24T | Human | Esophagus | ESCC | 3.41e-12 | 2.57e-01 | 0.0596 |
55278 | QRSL1 | P2T-E | Human | Esophagus | ESCC | 3.73e-16 | 2.59e-01 | 0.1177 |
55278 | QRSL1 | P4T-E | Human | Esophagus | ESCC | 6.33e-19 | 2.56e-01 | 0.1323 |
55278 | QRSL1 | P5T-E | Human | Esophagus | ESCC | 3.16e-10 | 1.27e-01 | 0.1327 |
55278 | QRSL1 | P8T-E | Human | Esophagus | ESCC | 3.25e-06 | 1.20e-01 | 0.0889 |
55278 | QRSL1 | P9T-E | Human | Esophagus | ESCC | 1.19e-06 | 8.07e-02 | 0.1131 |
55278 | QRSL1 | P10T-E | Human | Esophagus | ESCC | 1.22e-12 | 1.44e-01 | 0.116 |
55278 | QRSL1 | P12T-E | Human | Esophagus | ESCC | 1.09e-17 | 2.70e-01 | 0.1122 |
55278 | QRSL1 | P15T-E | Human | Esophagus | ESCC | 3.21e-19 | 2.78e-01 | 0.1149 |
55278 | QRSL1 | P16T-E | Human | Esophagus | ESCC | 1.19e-18 | 3.38e-01 | 0.1153 |
55278 | QRSL1 | P19T-E | Human | Esophagus | ESCC | 7.89e-05 | 3.86e-01 | 0.1662 |
55278 | QRSL1 | P20T-E | Human | Esophagus | ESCC | 3.40e-07 | 1.17e-01 | 0.1124 |
55278 | QRSL1 | P21T-E | Human | Esophagus | ESCC | 1.71e-14 | 1.76e-01 | 0.1617 |
55278 | QRSL1 | P22T-E | Human | Esophagus | ESCC | 1.38e-03 | 2.40e-02 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003164714 | Breast | IDC | regulation of protein stability | 50/1434 | 298/18723 | 1.14e-07 | 6.57e-06 | 50 |
GO:00325432 | Breast | IDC | mitochondrial translation | 13/1434 | 76/18723 | 4.81e-03 | 3.67e-02 | 13 |
GO:003164724 | Breast | DCIS | regulation of protein stability | 51/1390 | 298/18723 | 1.63e-08 | 1.15e-06 | 51 |
GO:003254311 | Breast | DCIS | mitochondrial translation | 13/1390 | 76/18723 | 3.70e-03 | 2.99e-02 | 13 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0031647111 | Esophagus | ESCC | regulation of protein stability | 223/8552 | 298/18723 | 5.76e-25 | 1.52e-22 | 223 |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
GO:003254314 | Esophagus | ESCC | mitochondrial translation | 68/8552 | 76/18723 | 1.02e-15 | 6.86e-14 | 68 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:003164722 | Liver | HCC | regulation of protein stability | 211/7958 | 298/18723 | 2.29e-23 | 5.01e-21 | 211 |
GO:01400531 | Liver | HCC | mitochondrial gene expression | 82/7958 | 108/18723 | 1.49e-12 | 7.20e-11 | 82 |
GO:00325431 | Liver | HCC | mitochondrial translation | 62/7958 | 76/18723 | 2.95e-12 | 1.34e-10 | 62 |
GO:00065202 | Liver | HCC | cellular amino acid metabolic process | 167/7958 | 284/18723 | 1.91e-08 | 4.56e-07 | 167 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
GO:003164720 | Oral cavity | OSCC | regulation of protein stability | 193/7305 | 298/18723 | 1.30e-19 | 1.95e-17 | 193 |
GO:01400533 | Oral cavity | OSCC | mitochondrial gene expression | 78/7305 | 108/18723 | 2.37e-12 | 9.86e-11 | 78 |
GO:00325434 | Oral cavity | OSCC | mitochondrial translation | 59/7305 | 76/18723 | 7.21e-12 | 2.70e-10 | 59 |
GO:00063991 | Oral cavity | OSCC | tRNA metabolic process | 101/7305 | 179/18723 | 1.65e-06 | 2.15e-05 | 101 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
QRSL1 | SNV | Missense_Mutation | rs761098365 | c.677C>T | p.Ser226Leu | p.S226L | Q9H0R6 | protein_coding | deleterious(0.02) | possibly_damaging(0.672) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
QRSL1 | SNV | Missense_Mutation | c.394N>C | p.Asp132His | p.D132H | Q9H0R6 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-BH-A0W7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
QRSL1 | deletion | Frame_Shift_Del | c.196delN | p.Asp67IlefsTer2 | p.D67Ifs*2 | Q9H0R6 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | |||
QRSL1 | SNV | Missense_Mutation | c.650N>A | p.Arg217His | p.R217H | Q9H0R6 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
QRSL1 | SNV | Missense_Mutation | c.1241N>C | p.Gly414Ala | p.G414A | Q9H0R6 | protein_coding | deleterious(0.03) | possibly_damaging(0.665) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
QRSL1 | SNV | Missense_Mutation | rs761098365 | c.677N>T | p.Ser226Leu | p.S226L | Q9H0R6 | protein_coding | deleterious(0.02) | possibly_damaging(0.672) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
QRSL1 | SNV | Missense_Mutation | c.1010N>T | p.Ser337Leu | p.S337L | Q9H0R6 | protein_coding | deleterious(0.02) | possibly_damaging(0.672) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
QRSL1 | SNV | Missense_Mutation | rs761098365 | c.677N>T | p.Ser226Leu | p.S226L | Q9H0R6 | protein_coding | deleterious(0.02) | possibly_damaging(0.672) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
QRSL1 | SNV | Missense_Mutation | rs761098365 | c.677N>T | p.Ser226Leu | p.S226L | Q9H0R6 | protein_coding | deleterious(0.02) | possibly_damaging(0.672) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
QRSL1 | SNV | Missense_Mutation | rs776695628 | c.542C>T | p.Ala181Val | p.A181V | Q9H0R6 | protein_coding | tolerated(0.07) | benign(0.442) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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