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Gene: PVT1 |
Gene summary for PVT1 |
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Gene information | Species | Human | Gene symbol | PVT1 | Gene ID | 5820 |
Gene name | Pvt1 oncogene | |
Gene Alias | LINC00079 | |
Cytomap | 8q24.21 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5820 | PVT1 | CCI_1 | Human | Cervix | CC | 4.30e-25 | 1.41e+00 | 0.528 |
5820 | PVT1 | CCI_2 | Human | Cervix | CC | 2.23e-25 | 2.15e+00 | 0.5249 |
5820 | PVT1 | CCI_3 | Human | Cervix | CC | 1.15e-49 | 1.70e+00 | 0.516 |
5820 | PVT1 | CCII_1 | Human | Cervix | CC | 2.14e-40 | 9.05e-01 | 0.3249 |
5820 | PVT1 | Tumor | Human | Cervix | CC | 3.40e-02 | 6.37e-02 | 0.1241 |
5820 | PVT1 | sample3 | Human | Cervix | CC | 1.95e-08 | 1.63e-01 | 0.1387 |
5820 | PVT1 | T1 | Human | Cervix | CC | 2.84e-02 | 1.05e-01 | 0.0918 |
5820 | PVT1 | T3 | Human | Cervix | CC | 1.95e-08 | 1.47e-01 | 0.1389 |
5820 | PVT1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.28e-10 | -4.88e-01 | -0.1808 |
5820 | PVT1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.29e-03 | 4.78e-01 | -0.1088 |
5820 | PVT1 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.83e-10 | -5.43e-01 | -0.1954 |
5820 | PVT1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.29e-05 | -8.54e-01 | -0.2602 |
5820 | PVT1 | HTA11_83_2000001011 | Human | Colorectum | SER | 6.50e-06 | -6.10e-01 | -0.1526 |
5820 | PVT1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.22e-06 | -3.51e-01 | -0.1464 |
5820 | PVT1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.27e-09 | 1.23e+00 | -0.059 |
5820 | PVT1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.94e-04 | -7.90e-01 | -0.1706 |
5820 | PVT1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.04e-10 | -1.00e+00 | -0.2061 |
5820 | PVT1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.21e-02 | -7.77e-01 | -0.1462 |
5820 | PVT1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.95e-02 | -6.09e-01 | -0.0179 |
5820 | PVT1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 9.20e-06 | 7.05e-01 | 0.0588 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5820 | PVT1 | NA | GLIVEC | GLIVEC | 15251464 |
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