![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PUSL1 |
Gene summary for PUSL1 |
![]() |
Gene information | Species | Human | Gene symbol | PUSL1 | Gene ID | 126789 |
Gene name | pseudouridine synthase like 1 | |
Gene Alias | PUSL1 | |
Cytomap | 1p36.33 | |
Gene Type | protein-coding | GO ID | GO:0001522 | UniProtAcc | Q8N0Z8 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
126789 | PUSL1 | LZE4T | Human | Esophagus | ESCC | 4.77e-05 | 1.13e-01 | 0.0811 |
126789 | PUSL1 | LZE20T | Human | Esophagus | ESCC | 9.10e-04 | 1.03e-01 | 0.0662 |
126789 | PUSL1 | LZE24T | Human | Esophagus | ESCC | 2.02e-18 | 3.28e-01 | 0.0596 |
126789 | PUSL1 | P1T-E | Human | Esophagus | ESCC | 8.90e-03 | 2.92e-01 | 0.0875 |
126789 | PUSL1 | P2T-E | Human | Esophagus | ESCC | 5.35e-11 | 2.05e-01 | 0.1177 |
126789 | PUSL1 | P4T-E | Human | Esophagus | ESCC | 9.28e-31 | 7.51e-01 | 0.1323 |
126789 | PUSL1 | P5T-E | Human | Esophagus | ESCC | 3.32e-17 | 3.62e-01 | 0.1327 |
126789 | PUSL1 | P8T-E | Human | Esophagus | ESCC | 3.75e-15 | 2.14e-01 | 0.0889 |
126789 | PUSL1 | P9T-E | Human | Esophagus | ESCC | 1.66e-09 | 1.17e-01 | 0.1131 |
126789 | PUSL1 | P10T-E | Human | Esophagus | ESCC | 7.96e-15 | 2.63e-01 | 0.116 |
126789 | PUSL1 | P12T-E | Human | Esophagus | ESCC | 8.75e-12 | 1.99e-01 | 0.1122 |
126789 | PUSL1 | P15T-E | Human | Esophagus | ESCC | 1.39e-12 | 2.24e-01 | 0.1149 |
126789 | PUSL1 | P16T-E | Human | Esophagus | ESCC | 1.98e-05 | 1.32e-01 | 0.1153 |
126789 | PUSL1 | P17T-E | Human | Esophagus | ESCC | 5.26e-08 | 3.76e-01 | 0.1278 |
126789 | PUSL1 | P19T-E | Human | Esophagus | ESCC | 6.23e-04 | 5.33e-01 | 0.1662 |
126789 | PUSL1 | P20T-E | Human | Esophagus | ESCC | 1.28e-16 | 3.25e-01 | 0.1124 |
126789 | PUSL1 | P21T-E | Human | Esophagus | ESCC | 4.02e-22 | 4.87e-01 | 0.1617 |
126789 | PUSL1 | P22T-E | Human | Esophagus | ESCC | 2.61e-06 | 1.43e-01 | 0.1236 |
126789 | PUSL1 | P23T-E | Human | Esophagus | ESCC | 2.67e-18 | 4.35e-01 | 0.108 |
126789 | PUSL1 | P24T-E | Human | Esophagus | ESCC | 3.92e-11 | 1.85e-01 | 0.1287 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00064002 | Esophagus | ESCC | tRNA modification | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:00015221 | Esophagus | ESCC | pseudouridine synthesis | 16/8552 | 18/18723 | 1.78e-04 | 1.15e-03 | 16 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:0008033 | Liver | HCC | tRNA processing | 87/7958 | 127/18723 | 2.66e-09 | 7.23e-08 | 87 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:0009451 | Liver | HCC | RNA modification | 101/7958 | 167/18723 | 2.02e-06 | 2.78e-05 | 101 |
GO:0006400 | Liver | HCC | tRNA modification | 60/7958 | 90/18723 | 3.09e-06 | 4.09e-05 | 60 |
GO:00344709 | Oral cavity | OSCC | ncRNA processing | 263/7305 | 395/18723 | 4.38e-29 | 2.78e-26 | 263 |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
GO:00080332 | Oral cavity | OSCC | tRNA processing | 78/7305 | 127/18723 | 2.56e-07 | 4.00e-06 | 78 |
GO:00063991 | Oral cavity | OSCC | tRNA metabolic process | 101/7305 | 179/18723 | 1.65e-06 | 2.15e-05 | 101 |
GO:00094511 | Oral cavity | OSCC | RNA modification | 95/7305 | 167/18723 | 2.05e-06 | 2.62e-05 | 95 |
GO:00064001 | Oral cavity | OSCC | tRNA modification | 53/7305 | 90/18723 | 1.04e-04 | 7.70e-04 | 53 |
GO:0001522 | Oral cavity | OSCC | pseudouridine synthesis | 13/7305 | 18/18723 | 4.45e-03 | 1.79e-02 | 13 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PUSL1 | deletion | Frame_Shift_Del | rs764750132 | c.633delC | p.Glu212ArgfsTer26 | p.E212Rfs*26 | Q8N0Z8 | protein_coding | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PUSL1 | SNV | Missense_Mutation | novel | c.649N>A | p.Leu217Met | p.L217M | Q8N0Z8 | protein_coding | deleterious(0.04) | probably_damaging(0.992) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PUSL1 | SNV | Missense_Mutation | novel | c.598N>A | p.Val200Ile | p.V200I | Q8N0Z8 | protein_coding | tolerated(0.6) | benign(0.101) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
PUSL1 | SNV | Missense_Mutation | novel | c.880N>A | p.Leu294Met | p.L294M | Q8N0Z8 | protein_coding | tolerated_low_confidence(0.12) | benign(0.405) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PUSL1 | SNV | Missense_Mutation | rs201132832 | c.826N>A | p.Gly276Ser | p.G276S | Q8N0Z8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PUSL1 | SNV | Missense_Mutation | rs748869074 | c.703N>T | p.Arg235Trp | p.R235W | Q8N0Z8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PUSL1 | deletion | In_Frame_Del | rs776346419 | c.529_531delGAC | p.Asp177del | p.D177del | Q8N0Z8 | protein_coding | TCGA-BG-A0VW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PUSL1 | SNV | Missense_Mutation | rs766185058 | c.848N>C | p.Leu283Pro | p.L283P | Q8N0Z8 | protein_coding | tolerated(0.22) | benign(0.194) | TCGA-86-8674-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | vinblastine | PD |
PUSL1 | SNV | Missense_Mutation | c.107N>T | p.Arg36Leu | p.R36L | Q8N0Z8 | protein_coding | tolerated(0.51) | benign(0.109) | TCGA-21-5787-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |