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Gene: PTRF |
Gene summary for PTRF |
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Gene information | Species | Human | Gene symbol | PTRF | Gene ID | 284119 |
Gene name | caveolae associated protein 1 | |
Gene Alias | CAVIN | |
Cytomap | 17q21.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6NZI2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284119 | PTRF | AEH-subject1 | Human | Endometrium | AEH | 7.64e-34 | -5.31e-01 | -0.3059 |
284119 | PTRF | AEH-subject2 | Human | Endometrium | AEH | 3.44e-31 | -5.31e-01 | -0.2525 |
284119 | PTRF | AEH-subject3 | Human | Endometrium | AEH | 1.95e-33 | -5.31e-01 | -0.2576 |
284119 | PTRF | AEH-subject4 | Human | Endometrium | AEH | 3.34e-24 | -5.31e-01 | -0.2657 |
284119 | PTRF | AEH-subject5 | Human | Endometrium | AEH | 1.95e-33 | -5.31e-01 | -0.2953 |
284119 | PTRF | EEC-subject1 | Human | Endometrium | EEC | 8.01e-32 | -5.31e-01 | -0.2682 |
284119 | PTRF | EEC-subject2 | Human | Endometrium | EEC | 2.98e-34 | -5.31e-01 | -0.2607 |
284119 | PTRF | EEC-subject3 | Human | Endometrium | EEC | 6.74e-36 | -5.31e-01 | -0.2525 |
284119 | PTRF | EEC-subject4 | Human | Endometrium | EEC | 2.98e-34 | -5.31e-01 | -0.2571 |
284119 | PTRF | EEC-subject5 | Human | Endometrium | EEC | 1.16e-34 | -5.31e-01 | -0.249 |
284119 | PTRF | GSM5276934 | Human | Endometrium | EEC | 2.59e-36 | -5.31e-01 | -0.0913 |
284119 | PTRF | GSM5276935 | Human | Endometrium | EEC | 1.16e-34 | -5.31e-01 | -0.123 |
284119 | PTRF | GSM5276937 | Human | Endometrium | EEC | 2.35e-29 | -5.31e-01 | -0.0897 |
284119 | PTRF | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.43e-25 | -5.31e-01 | -0.1869 |
284119 | PTRF | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 8.55e-23 | -5.31e-01 | -0.1875 |
284119 | PTRF | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.84e-26 | -5.31e-01 | -0.1883 |
284119 | PTRF | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.16e-34 | -5.31e-01 | -0.1934 |
284119 | PTRF | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 6.74e-36 | -5.31e-01 | -0.1917 |
284119 | PTRF | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 4.20e-34 | -5.31e-01 | -0.1916 |
284119 | PTRF | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 4.51e-35 | -5.31e-01 | -0.1269 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTRF | SNV | Missense_Mutation | novel | c.981N>C | p.Lys327Asn | p.K327N | Q6NZI2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A6IW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTRF | SNV | Missense_Mutation | c.797N>T | p.Thr266Met | p.T266M | Q6NZI2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
PTRF | SNV | Missense_Mutation | novel | c.1060N>C | p.Glu354Gln | p.E354Q | Q6NZI2 | protein_coding | tolerated(0.07) | benign(0.354) | TCGA-BH-A1F8-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
PTRF | SNV | Missense_Mutation | c.104N>T | p.Pro35Leu | p.P35L | Q6NZI2 | protein_coding | tolerated(0.12) | benign(0.001) | TCGA-D8-A1XV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PTRF | SNV | Missense_Mutation | novel | c.941N>T | p.Ala314Val | p.A314V | Q6NZI2 | protein_coding | deleterious(0) | benign(0.242) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PTRF | SNV | Missense_Mutation | novel | c.838N>T | p.Arg280Cys | p.R280C | Q6NZI2 | protein_coding | deleterious(0) | possibly_damaging(0.862) | TCGA-VS-A9V5-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
PTRF | SNV | Missense_Mutation | c.506G>A | p.Ser169Asn | p.S169N | Q6NZI2 | protein_coding | tolerated(0.14) | benign(0.092) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PTRF | SNV | Missense_Mutation | c.652N>A | p.Ala218Thr | p.A218T | Q6NZI2 | protein_coding | tolerated(0.1) | benign(0.214) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PTRF | SNV | Missense_Mutation | novel | c.586N>A | p.Ala196Thr | p.A196T | Q6NZI2 | protein_coding | tolerated(0.57) | benign(0) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTRF | SNV | Missense_Mutation | c.764N>T | p.Thr255Met | p.T255M | Q6NZI2 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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