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Gene: PTPLAD1 |
Gene summary for PTPLAD1 |
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Gene information | Species | Human | Gene symbol | PTPLAD1 | Gene ID | 51495 |
Gene name | 3-hydroxyacyl-CoA dehydratase 3 | |
Gene Alias | B-IND1 | |
Cytomap | 15q22.31 | |
Gene Type | protein-coding | GO ID | GO:0000038 | UniProtAcc | Q9P035 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51495 | PTPLAD1 | Pt13.a | Human | Liver | HCC | 2.40e-33 | 6.85e-01 | 0.021 |
51495 | PTPLAD1 | Pt13.b | Human | Liver | HCC | 6.76e-61 | 7.56e-01 | 0.0251 |
51495 | PTPLAD1 | Pt13.c | Human | Liver | HCC | 2.72e-05 | 3.26e-01 | 0.0076 |
51495 | PTPLAD1 | Pt14.a | Human | Liver | HCC | 1.06e-18 | 6.78e-01 | 0.0169 |
51495 | PTPLAD1 | Pt14.b | Human | Liver | HCC | 4.34e-15 | 4.54e-01 | 0.018 |
51495 | PTPLAD1 | Pt14.d | Human | Liver | HCC | 9.48e-12 | 2.80e-01 | 0.0143 |
51495 | PTPLAD1 | GSM5353216_PA_PB1A_Pool_1_3_S50_L002 | Human | Prostate | Tumor | 7.14e-06 | 6.33e-01 | 0.159 |
51495 | PTPLAD1 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 1.81e-18 | 6.47e-01 | 0.1633 |
51495 | PTPLAD1 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 4.57e-21 | 6.41e-01 | 0.1608 |
51495 | PTPLAD1 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 4.78e-16 | 5.81e-01 | 0.1604 |
51495 | PTPLAD1 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 1.24e-08 | 3.92e-01 | 0.1621 |
51495 | PTPLAD1 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 5.40e-10 | 4.83e-01 | 0.1602 |
51495 | PTPLAD1 | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 5.29e-08 | 5.29e-01 | 0.1608 |
51495 | PTPLAD1 | GSM5353237_PA_PR5251_T2_S8_L001 | Human | Prostate | Tumor | 1.86e-05 | 4.18e-01 | 0.1622 |
51495 | PTPLAD1 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 8.26e-14 | 4.73e-01 | 0.1575 |
51495 | PTPLAD1 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 3.90e-06 | 3.64e-01 | 0.1545 |
51495 | PTPLAD1 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 1.00e-06 | 3.91e-01 | 0.1569 |
51495 | PTPLAD1 | P1_S1_AK | Human | Skin | AK | 4.01e-03 | -1.24e-01 | -0.3399 |
51495 | PTPLAD1 | P2_S3_AK | Human | Skin | AK | 4.01e-03 | -1.24e-01 | -0.3287 |
51495 | PTPLAD1 | P2_S4_SCCIS | Human | Skin | SCCIS | 8.47e-03 | -1.24e-01 | -0.3043 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012129 | Esophagus | ESCC | Fatty acid metabolism | 41/4205 | 57/8465 | 5.13e-04 | 1.75e-03 | 8.98e-04 | 41 |
hsa0121214 | Esophagus | ESCC | Fatty acid metabolism | 41/4205 | 57/8465 | 5.13e-04 | 1.75e-03 | 8.98e-04 | 41 |
hsa012126 | Liver | NAFLD | Fatty acid metabolism | 17/1043 | 57/8465 | 3.43e-04 | 5.93e-03 | 4.78e-03 | 17 |
hsa0121211 | Liver | NAFLD | Fatty acid metabolism | 17/1043 | 57/8465 | 3.43e-04 | 5.93e-03 | 4.78e-03 | 17 |
hsa012122 | Liver | Cirrhotic | Fatty acid metabolism | 32/2530 | 57/8465 | 3.12e-05 | 2.47e-04 | 1.52e-04 | 32 |
hsa01040 | Liver | Cirrhotic | Biosynthesis of unsaturated fatty acids | 14/2530 | 27/8465 | 1.36e-02 | 4.25e-02 | 2.62e-02 | 14 |
hsa012123 | Liver | Cirrhotic | Fatty acid metabolism | 32/2530 | 57/8465 | 3.12e-05 | 2.47e-04 | 1.52e-04 | 32 |
hsa010401 | Liver | Cirrhotic | Biosynthesis of unsaturated fatty acids | 14/2530 | 27/8465 | 1.36e-02 | 4.25e-02 | 2.62e-02 | 14 |
hsa012124 | Liver | HCC | Fatty acid metabolism | 45/4020 | 57/8465 | 1.05e-06 | 1.10e-05 | 6.09e-06 | 45 |
hsa000622 | Liver | HCC | Fatty acid elongation | 20/4020 | 27/8465 | 4.58e-03 | 1.36e-02 | 7.55e-03 | 20 |
hsa010402 | Liver | HCC | Biosynthesis of unsaturated fatty acids | 19/4020 | 27/8465 | 1.37e-02 | 3.33e-02 | 1.85e-02 | 19 |
hsa012125 | Liver | HCC | Fatty acid metabolism | 45/4020 | 57/8465 | 1.05e-06 | 1.10e-05 | 6.09e-06 | 45 |
hsa0006211 | Liver | HCC | Fatty acid elongation | 20/4020 | 27/8465 | 4.58e-03 | 1.36e-02 | 7.55e-03 | 20 |
hsa010403 | Liver | HCC | Biosynthesis of unsaturated fatty acids | 19/4020 | 27/8465 | 1.37e-02 | 3.33e-02 | 1.85e-02 | 19 |
hsa012128 | Oral cavity | OSCC | Fatty acid metabolism | 35/3704 | 57/8465 | 5.37e-03 | 1.29e-02 | 6.55e-03 | 35 |
hsa0121213 | Oral cavity | OSCC | Fatty acid metabolism | 35/3704 | 57/8465 | 5.37e-03 | 1.29e-02 | 6.55e-03 | 35 |
hsa012127 | Prostate | BPH | Fatty acid metabolism | 19/1718 | 57/8465 | 1.44e-02 | 4.17e-02 | 2.58e-02 | 19 |
hsa0121212 | Prostate | BPH | Fatty acid metabolism | 19/1718 | 57/8465 | 1.44e-02 | 4.17e-02 | 2.58e-02 | 19 |
hsa0121221 | Prostate | Tumor | Fatty acid metabolism | 23/1791 | 57/8465 | 7.60e-04 | 3.59e-03 | 2.23e-03 | 23 |
hsa010404 | Prostate | Tumor | Biosynthesis of unsaturated fatty acids | 12/1791 | 27/8465 | 5.53e-03 | 1.93e-02 | 1.19e-02 | 12 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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